RelA

Isoforms Recommended:	RelA/p65

By Targets:	Androgen Receptor (2) Apoptosis (4) Drug Derivative (2) ERK (2) Histone Methyltransferase (1) Interleukin Related (2) Ligands for Target Protein for PROTAC (1) NF-κB (9) p38 MAPK (2) PPAR (2) PROTACs (1) Ras (1) Reference Standards (2) Small Interfering RNA (siRNA) (3) TNF Receptor (2)
By Research Areas:	Cancer (8) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-170316

Ibetazol	Ras	Cancer
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, *RelA/p65* and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .

HY-174864

JP-163-16	PROTACs NF-κB Apoptosis	Cancer
JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand (HY-174865); Blue: CRBN Ligand (HY-A0003); Black: Linker; CRBN Ligand+Linker (HY-160241)) .

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	NF-κB TNF Receptor Interleukin Related Drug Derivative	Inflammation/Immunology Cancer
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

HY-N7043

Isosilybin A 2 Publications Verification	Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor	Inflammation/Immunology Cancer
Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

HY-RS11827

Rela Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NF-κB	Others
Rela Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rela Mouse Pre-designed siRNA Set A Rela Mouse Pre-designed siRNA Set A

HY-174865

MMH-165-26	Ligands for Target Protein for PROTAC NF-κB Apoptosis	Cancer
MMH-165-26 is a ligand for *RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC₅₀* = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16 (HY-174864) .

HY-121309R

Doxorubicinone (Standard) Adriamycin aglycone (Standard); Adriamycinone (Standard)	Reference Standards NF-κB TNF Receptor Interleukin Related Drug Derivative	Inflammation/Immunology Cancer
Doxorubicinone (Adriamycin aglycone) (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research.

HY-RS11828

Rela Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NF-κB	Others
Rela Rat Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rela Rat Pre-designed siRNA Set A Rela Rat Pre-designed siRNA Set A

HY-RS11826

RELA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NF-κB	Others
RELA Human Pre-designed siRNA Set A contains three designed siRNAs for RELA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RELA Human Pre-designed siRNA Set A RELA Human Pre-designed siRNA Set A

HY-101512D

rel-A-395 hydrochloride	Histone Methyltransferase	Cancer
rel-A-395 hydrochloride is the relative configuration of A-395 (HY-101512) hydrochloride. A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC₅₀ of 18 nM .

HY-N7043R

Isosilybin A (Standard)	Reference Standards Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor	Inflammation/Immunology Cancer
Isosilybin A (Standard) is the analytical standard of Isosilybin A (HY-N7043). Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library	1,651 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,651 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

NF-κB Signaling Compound Library

1,651 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,651 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	NF-κB TNF Receptor Interleukin Related Drug Derivative
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

HY-N7043

Isosilybin A 2 Publications Verification	Flavanonols Flavonoids Glycine soya Classification of Application Fields Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Source Classification Cancer	Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor
Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

HY-121309R

Doxorubicinone (Standard) Adriamycin aglycone (Standard); Adriamycinone (Standard)	Quinones Structural Classification Anthraquinones Endogenous metabolite Source Classification	Reference Standards NF-κB TNF Receptor Interleukin Related Drug Derivative
Doxorubicinone (Adriamycin aglycone) (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research.

HY-N7043R

Isosilybin A (Standard)	Flavanonols Structural Classification Flavonoids Glycine soya Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Source Classification	Reference Standards Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor
Isosilybin A (Standard) is the analytical standard of Isosilybin A (HY-N7043). Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73681

	RelA/NFkB p65 Protein, Human (GST) 3 Publications Verification Transcription factor p65; RelA; NFKB3	Human	E. coli
	RelA/NF-kappa-B p65 is a key transcription factor that mediates inflammatory, immune, and cellular processes in response to multiple stimuli. Inactive in the cytoplasm, it forms a complex with I-kappa-B. RelA/NFkB p65 Protein, Human (GST) is the recombinant human-derived RelA/NFkB p65, expressed by E. coli, with N-GST labeled tag.

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Species
Source
Tag
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Gene ID
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Host:	Mouse (5) Rabbit (11)
Reactivity:	Human (16) Rat (12) Mouse (15) Monkey (3) Rabbit (2)
Application:	IHC-P (14) ICC/IF (11) IF-Tissue (1) IP (7) IHC-F (4) WB (16) FC (2) ELISA (7)
Isotype:	IgG2a,IgG/Kappa (1) IgG (10) IgG1 (4) IgG/Kappa (1)
Conjugation:	Non-conjugated (16)
Clonality:	Polyclonal (4) Monoclonal (9) Monoclonal Antibody (1) Recombinant (3)
Modification:	Phosphorylated (5) Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84479

	NF-κB p65 Antibody (YA4176) NFkappaB p65; p65; NFKB3; RelA	WB, IHC-P, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	NF-κB p65 Antibody (YA4176) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-κB p65.

HY-P84479A

	NF-κB p65 Antibody (YA4176)(PBS only) NFkappaB p65; p65; NFKB3; RelA	WB, IHC-P, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	NF-κB p65 Antibody (YA4176) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-κB p65.

HY-P80765

	NF-KB p65 Antibody (YA268) 5 Publications Verification NFKB3; RelA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	NF-KB p65 Antibody (YA268) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p65.

HY-P80839

	Phospho-NF-KB p65 (Ser536) Antibody Maximum Cited Publications 6 Publications Verification Phospho-NF-κB p65; NFKB3; RelA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-NF-KB p65 (Ser536) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-NF-KB p65 (Ser536).

HY-P85677

	NFkB p65 Antibody (YA5369) RelA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3	WB, ICC/IF, ELISA	Human, Mouse
	NFkB p65 Antibody (YA5369) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NFkB p65.

HY-P86492

	NF-κB p65 Antibody (YA6184) RelA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

HY-P86720

	NF-KB p65 Antibody (YA6412) TF65_HUMAN; Transcription factor p65; RelA; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RelA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p65.

HY-P86687

	NF-KB p65 Antibody (YA6379) TF65_HUMAN; Transcription factor p65; RelA; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RelA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p65.

HY-P86720A

	NF-KB p65 Antibody (YA6412)(PBS only) TF65_HUMAN; Transcription factor p65; RelA; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RelA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NF-KB p65 Antibody (YA6412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p65.

HY-P80470

	Phospho-NF-κB p65 (Ser529) Antibody (YA170) 2 Publications Verification	WB, IP, FC, IHC-P	Human
	Phospho-NF-κB p65 (Ser529) Antibody (YA170) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-NF-κB p65 (Ser529).

HY-P80245

	NF-KB p65 Antibody (YA267) Maximum Cited Publications 6 Publications Verification NF-κB p65 Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	NF-KB p65 Antibody (YA267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p65.

HY-P81238

	Phospho-NF-κB p65 (Ser536) Antibody 3 Publications Verification Phospho-NF-KB p65 (Ser536) ; NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RelA(phospho S536); NF kB P65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RelA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat, Monkey
	Phospho-NF-κB p65 (Ser536) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-NF-κB p65 (Ser536).

HY-P80840

	Phospho-NF-KB p65 (Thr254) Antibody NFKB3; RelA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-NF-KB p65 (Thr254) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-NF-KB p65 (Thr254).

HY-P80644

	DRP1 Antibody 4 Publications Verification DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-RelA	WB, IHC-P	Human, Mouse, Rat
	DRP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DRP1.

HY-P86613

	DRP1 Antibody (YA6305) DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-RelA	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	DRP1 Antibody (YA6305) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DRP1.

HY-P86120

	Phospho-DRP1(Ser616) Antibody (YA5812) DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-RelA	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-DRP1(Ser616) Antibody (YA5812) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-DRP1(Ser616).

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Cat. No.	Product Name		Classification

HY-RS11827

Rela Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rela Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11828

Rela Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Rela Rat Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11826

RELA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RELA Human Pre-designed siRNA Set A contains three designed siRNAs for RELA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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