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Results for "

RyR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) ATP Synthase (1) Autophagy (2) Calcium Channel (31) Calmodulin (1) FKBP (1) Fluorescent Dye (1) Insecticide (1) Isotope-Labeled Compounds (2) Myosin (1) Parasite (8) Potassium Channel (5) Reactive Oxygen Species (ROS) (4) Reference Standards (5) Small Interfering RNA (siRNA) (9) Sodium Channel (7) Topoisomerase (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (19) Infection (5) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (11)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

Inhibitors & Agonists

Peptides

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Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12542

Dantrolene Maximum Cited Publications 15 Publications Verification F 368	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca ²⁺ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties .

HY-14657

Dantrolene sodium Maximum Cited Publications 15 Publications Verification F 440	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease
Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca ²⁺ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties .

HY-W010950

Flecainide 3 Publications Verification	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-12542A

Dantrolene sodium hemiheptahydrate Maximum Cited Publications 15 Publications Verification Dantrolene sodium hydrate	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease
Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca ²⁺ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties .

HY-119850

Aladorian ARM036; S44121	Calcium Channel	Cardiovascular Disease
Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .

HY-15292

S107 1 Publications Verification	Calcium Channel	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes *RyR2* channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca ²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .

HY-159502

Surlorian ARM210	Parasite	Infection
Surlorian is a ryanodine receptor (RyR) stabilizer .

HY-149662

TMDJ-035	Calcium Channel ATP Synthase Myosin	Cardiovascular Disease
TMDJ-035 is a high-affinity, selective *RyR2* inhibitor with an EC₅₀ of 0.0130 μM. TMDJ-035 reduces *RyR2* protein expression without affecting action potential-induced Ca ²⁺ transients. TMDJ-035 decreases ATP content and intracellular Ca ²⁺ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in Myosin heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias .

HY-113920A

Azumolene 3 Publications Verification EU4093 free base	Calcium Channel	Metabolic Disease
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research .

HY-W010950A

Flecainide hydrochloride 3 Publications Verification	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-A0079

Tetracaine Amethocaine	Sodium Channel Calcium Channel	Neurological Disease
Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor. Tetracaine blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. Tetracaine exhibits biphasic effects on spontaneous sarcoplasmic reticulum Ca ²⁺ release in Ca ²⁺-overloaded ventricular myocytes, and increases sarcoplasmic reticulum Ca ²⁺ load. Tetracaine can be used in research related to eye diseases .

HY-N7491A

Ent-(+)-Verticilide	Calcium Channel	Cancer
ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .

HY-141564

RyR1-IN-1	Calcium Channel	Neurological Disease
RyR1-IN-1 (Compound 1) is a *RyR1* inhibitor with an IC₅₀ of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke .

HY-113040A

(17R,18S)-Epoxyeicosatetraenoic acid 17(R),18(S)-EETeTr	Calcium Channel	Cardiovascular Disease
(17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia .

HY-P3037A

Imperatoxin A TFA	Calcium Channel	Neurological Disease
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca ²⁺-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5114A

Maurocalcine TFA	Calcium Channel	Others
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques .

HY-101775A

9-Hydroxyellipticine hydrochloride	Topoisomerase	Cardiovascular Disease Cancer
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and *RyR*. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

HY-W339331

Flubendiamide NNI-0001	Insecticide Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Infection Metabolic Disease
Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis .

HY-Z7733

O-Desmethylcarvedilol Desmethylcarvedilol; BM-14242	Calcium Channel	Metabolic Disease
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 ^R4496C) mutation (IC₅₀ = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED₅₀s = 32 and 5 µg/kg, respectively) .

HY-W010950S

Flecainide-d3	Potassium Channel Sodium Channel Isotope-Labeled Compounds	Cardiovascular Disease
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-RS26453

Ryr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ryr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ryr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ryr2 Rat Pre-designed siRNA Set A Ryr2 Rat Pre-designed siRNA Set A

HY-RS12369

RYR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR2 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR2 Human Pre-designed siRNA Set A RYR2 Human Pre-designed siRNA Set A

HY-RS12368

RYR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR1 Human Pre-designed siRNA Set A RYR1 Human Pre-designed siRNA Set A

HY-178437

Bastadins-5	Calcium Channel	Metabolic Disease
Bastadins-5 is a potent stabilizer for the open state of *RYR1*. Bastadins-5 enhances Ca ²⁺-induced Ca ²⁺ release. Bastadins-5 can be used in research on central nuclear disease and malignant hypothermia .

HY-164631

EL20	Calcium Channel	Cardiovascular Disease
EL20 is a selective cardiac ryanodine receptor 2 (RyR2) inhibitor. EL20 inhibits diastolic Ca ²⁺ leakage from the sarcoplasmic reticulum, reducing delayed afterdepolarizations and triggered arrhythmias. EL20 is promising for research of cardiovascular diseases .

HY-172152

MP-010	FKBP Calcium Channel	Neurological Disease
MP-010 is a FKBP12 ligand that regulates cytosolic calcium by stabilizing *RyR* channel activity. MP-010 promotes functional improvement in SOD1 ^G93A amyotrophic lateral sclerosis (ALS) mice, as evidenced by improved motor coordination, increased integrity of neuromuscular junctions, and significantly enhanced survival of spinal motor neurons. MP-010 can be used for research in the field of neurological diseases .

HY-P5424

RyR1(3614-3643)	Calmodulin	Others
RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)

HY-149779

RyR2 stabilizer-1	Calcium Channel	Cardiovascular Disease
RyR2 stabilizer-1 (compound 12a) is a potent *RyR2* stabilizer and SERCA2a activator with EC₅₀s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca ²⁺ leakage from the SR RyR2 while promoting SERCA2 to pump Ca ²⁺ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias .

HY-175506

RyRs activator 6	Parasite Calcium Channel	Infection
RyRs activator 6 (compound C3) is a ryanodine receptor (RyRs) activator that activates calcium release in insect neurons. RyRs activator 6 has insecticidal activity .

HY-RS19158

Ryr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ryr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ryr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ryr3 Mouse Pre-designed siRNA Set A Ryr3 Mouse Pre-designed siRNA Set A

HY-RS12370

RYR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR3 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR3 Human Pre-designed siRNA Set A RYR3 Human Pre-designed siRNA Set A

HY-RS19951

Ryr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ryr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ryr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ryr2 Mouse Pre-designed siRNA Set A Ryr2 Mouse Pre-designed siRNA Set A

HY-P3037

Imperatoxin A	Calcium Channel	Neurological Disease
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs) enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-RS19950

Ryr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ryr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ryr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ryr1 Mouse Pre-designed siRNA Set A Ryr1 Mouse Pre-designed siRNA Set A

HY-146109

RyRs activator 1	Parasite	Infection
RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .

HY-146110

RyRs activator 2	Parasite	Infection
RyRs activator 2 (compound 7o) is a potent activator of ryanodine receptors (RyRs). RyRs activator 2 is 30% larvicidal activity, comparable to chlorantraniliprole (30%) and better than cyantraniliprole (10%) .

HY-12542R

Dantrolene (Standard) F 368 (Standard)	Reference Standards Calcium Channel Autophagy	Neurological Disease Inflammation/Immunology
Dantrolene (Standard) is the analytical standard of Dantrolene. This product is intended for research and analytical applications. Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-P5319

MCaE12A	Calcium Channel	Others
MCaE12A is a high-affinity modulator of *RyR2* and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-12542AR

Dantrolene sodium hemiheptahydrate (Standard) Dantrolene sodium hydrate (Standard)	Reference Standards Calcium Channel Autophagy	Others
Dantrolene (sodium hemiheptahydrate) (Standard) is the analytical standard of Dantrolene (sodium hemiheptahydrate). This product is intended for research and analytical applications. Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-156082

RyRs activator 3	Parasite Calcium Channel	Others
RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-155334

RyRs activator 4	Parasite	Others
RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC₅₀ value of 1.32 mg/L .

HY-119581

MBED 9-Methyl-7-bromoeudistomin D	Fluorescent Dye	Neurological Disease
MBED (9-Methyl-7-bromoeudistomin D) is a *RyR* agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs .

HY-149697

Insecticidal agent 6	Parasite	Others
Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC₅₀ value of 0.6308 µM against S. frugiperda *RyRs*. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases .

HY-155394

RyRs activator 5	Calcium Channel	Metabolic Disease
RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .

HY-119850A

Aladorian sodium ARM036 sodium; S44121 sodium	Calcium Channel	Cardiovascular Disease
Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca ²⁺ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .

HY-138806

PAQ	Calcium Channel	Neurological Disease
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells .

HY-W010950AR

Flecainide hydrochloride (Standard)	Reference Standards Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-163157

Insecticidal agent 7	Parasite	Others
Insecticidal agent 7 (Compound 21m) is an insecticide that targets the insect ryanodine receptors (RyRs) with a LC₅₀ of 0.0937 mg/L for the Plutella xylostella. Insecticidal agent 7 (Compound 21m) exhibits good selectivity and low toxicity towards non-target organisms .

HY-166478S

O-Desmethyl carvedilol-d5 Desmethylcarvedilol-d₅; BM-14242-d₅	Isotope-Labeled Compounds Calcium Channel	Metabolic Disease
O-Desmethyl carvedilol-d₅ (Desmethylcarvedilol-d₅) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 ^R4496C) mutation (IC₅₀ = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED₅₀s = 32 and 5 μg/kg, respectively) .

Cat. No.	Product Name	Target	Research Area

HY-P3037A

Imperatoxin A TFA	Calcium Channel	Neurological Disease
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca ²⁺-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5114A

Maurocalcine TFA	Calcium Channel	Others
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques .

HY-P5424

RyR1(3614-3643)	Calmodulin	Others
RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)

HY-P3037

Imperatoxin A	Calcium Channel	Neurological Disease
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs) enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5319

MCaE12A	Calcium Channel	Others
MCaE12A is a high-affinity modulator of *RyR2* and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101775A

9-Hydroxyellipticine hydrochloride	Alkaloids Carbazole Alkaloids	Topoisomerase
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and *RyR*. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

HY-101775AR

9-Hydroxyellipticine hydrochloride (Standard)	Alkaloids Carbazole Alkaloids	Reference Standards Topoisomerase
9-Hydroxyellipticine (hydrochloride) (Standard) is the analytical standard of 9-Hydroxyellipticine (hydrochloride). This product is intended for research and analytical applications. 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705148

	*HLA-C07:02:01&B2M&RYR (RYRPGTVAL) Monomer Protein, Human (HEK293, His-Avi)** HLA-C07:02:01 & B2M & RyR*PGTVAL	Human	HEK293

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HY-W010950S

Flecainide-d3
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-166478S

O-Desmethyl carvedilol-d5

O-Desmethyl carvedilol-d₅ (Desmethylcarvedilol-d₅) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 ^R4496C) mutation (IC₅₀ = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED₅₀s = 32 and 5 μg/kg, respectively) .

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