142 Results for "

STAT3 signaling pathway

" in MedChemExpress (MCE) Product Catalog:
Products (142)

142 Results for "STAT3 signaling pathway" in MCE Product Catalog:

24
Scutellarin
Scutellarin
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24 Publications Verification
Cat. No.: HY-N0751
CAS No.: 27740-01-8
Category:  

Infection Flavonoids Flavones Labiatae Phenols Polyphenols Plants Disease Research Fields Medicago truncatula Gaertn.

Target:  

STAT Akt HIV

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
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21
Liensinine
Liensinine
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21 Cited Publications
Cat. No.: HY-N0484
CAS No.: 2586-96-1
Category:  

Cardiovascular Disease Alkaloids other families Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers

Target:  

Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt

Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke .
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21
Liensinine perchlorate
Liensinine perchlorate
0 Images
21 Cited Publications
Cat. No.: HY-N5014
CAS No.: 2385-63-9
Category:  

Alkaloids other families Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt

Liensinine perchlorate is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine perchlorate suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine perchlorate activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine perchlorate exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine perchlorate can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke .
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20
Oroxylin A
Oroxylin A
0 Images
20 Cited Publications
Cat. No.: HY-N0560
CAS No.: 480-11-5
Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Bignoniaceae Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .
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11
Diosgenin
Diosgenin
0 Images
11 Cited Publications
Cat. No.: HY-N0177
CAS No.: 512-04-9
Category:  

Human Gut Microbiota Metabolites other families Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids

Target:  

STAT MicroRNA

Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
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11
Ginsenoside Rk1
Ginsenoside Rk1
0 Images
11 Cited Publications
Cat. No.: HY-N2515
CAS No.: 494753-69-4
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae

Target:  

NF-κB PI3K JAK Apoptosis

Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .
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10
Ganoderic acid A
Ganoderic acid A
0 Images
10 Cited Publications
Cat. No.: HY-N1447
CAS No.: 81907-62-2
Category:  

Triterpenes Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

Free Radical Scavengers Apoptosis Autophagy Endogenous Metabolite

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.
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9
Glycochenodeoxycholic acid
Glycochenodeoxycholic acid
0 Images
9 Cited Publications
Cat. No.: HY-N2334
CAS No.: 640-79-9
Synonyms: Chenodeoxycholylglycine
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Endogenous Metabolite Caspase Apoptosis BCL6 Interleukin Related STAT

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .
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9
Glycochenodeoxycholic acid sodium salt
Glycochenodeoxycholic acid sodium salt
0 Images
9 Cited Publications
Cat. No.: HY-N2334A
CAS No.: 16564-43-5
Synonyms: Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase

Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .
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5
Betulinaldehyde
Betulinaldehyde
0 Images
5 Cited Publications
Cat. No.: HY-N0084
CAS No.: 13159-28-9
Synonyms: Betulinic aldehyde; Betunal
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:  

Bacterial

Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca 2+/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.
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4
Nitidine chloride
Nitidine chloride
0 Images
4 Cited Publications
Cat. No.: HY-N0498
CAS No.: 13063-04-2
Category:  

Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .
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4
KW-2478
KW-2478
0 Images
4 Cited Publications
Cat. No.: HY-13468
CAS No.: 819812-04-9
Purity:  99.53%
Target:  

HSP Apoptosis Bcr-Abl p38 MAPK CDK STAT

Research Areas:  

Cancer

KW-2478 is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 downregulates STAT3 expression. KW-2478 may be used in research on cancers such as CML and liver cancer .
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4
Garcinone D
Garcinone D
0 Images
4 Cited Publications
Cat. No.: HY-N6953
CAS No.: 107390-08-9
Category:  

Xanthones Guttiferae Garcinia mangostana Linn. Phenols Polyphenols Plants

Target:  

STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)

Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer .
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4
Angoline
Angoline
0 Images
4 Cited Publications
Cat. No.: HY-N7674
CAS No.: 21080-31-9
Category:  

Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae Cancer

Target:  

Interleukin Related STAT

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .
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3
Atractylenolide II
Atractylenolide II
0 Images
3 Cited Publications
Cat. No.: HY-N0202
CAS No.: 73069-14-4
Synonyms: Asterolide
Category:  

Terpenoids Sesquiterpenes Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer

Target:  

ERK Apoptosis p38 MAPK Akt Src STAT

Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity .
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3
Broussonin E
Broussonin E
0 Images
3 Cited Publications
Cat. No.: HY-N2963
CAS No.: 90902-21-9
Category:  

Thymelaeaceae Daphne giraldii Nitsche Phenols Polyphenols Plants

Target:  

ERK p38 MAPK JAK STAT TNF Receptor Interleukin Related COX Arginase

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis .
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3
JMS-053
JMS-053
0 Images
3 Cited Publications
Cat. No.: HY-135457
CAS No.: 1954650-11-3
Purity:  ≥98.0%
Target:  

Phosphatase STAT Ras

Research Areas:  

Cancer

JMS-053 is an efficient and reversible PTP4A3 inhibitor, with an IC50 value of 18 nM. JMS-053 demonstrates broad PTP4A inhibitory activity with IC50s of 50 nM and 53 nM for PTP4A1 and PTP4A2, respectively. JMS-053 exhibits IC50 values of 92.6 nM and 207.6 nM for CDC25B and DUSP3, respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer, breast cancer and colon cancer .
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2
Phellodendrine chloride
Phellodendrine chloride
0 Images
2 Cited Publications
Cat. No.: HY-N0735
CAS No.: 104112-82-5
Category:  

Alkaloids Phellodendron amurense Rupr. Rutaceae Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP

Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .
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2
Mogrol
Mogrol
0 Images
2 Cited Publications
Cat. No.: HY-N2312
CAS No.: 88930-15-8
Category:  

Triterpenes Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Cancer

Target:  

ERK STAT

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
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2
Narasin
Narasin
0 Images
2 Cited Publications
Cat. No.: HY-121410
CAS No.: 55134-13-9
Purity:  ≥88.0%
Target:  

Bacterial Apoptosis Parasite NF-κB Antibiotic

Research Areas:  

Infection Cancer

Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways .
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