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antifungal activities

" in MedChemExpress (MCE) Product Catalog:

1038

Inhibitors & Agonists

6

Screening Libraries

2

Fluorescent Dyes

21

Biochemical Assay Reagents

43

Peptides

468

Natural
Products

56

Isotope-Labeled Compounds

1

Oligonucleotides

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0452
    Hyperoside
    20+ Cited Publications

    Quercetin 3-O-galactoside; Quercetin 3-O-β-D-galactopyranoside

    		 Influenza Virus Fungal NF-κB Apoptosis Infection Inflammation/Immunology Cancer
    Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis .
    Hyperoside
  • HY-N0540
    Cynaroside
    10+ Cited Publications

    Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside

    		 Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal Infection Cardiovascular Disease Cancer
    Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
    Cynaroside
  • HY-P1934A
    Cyclo(L-Phe-L-Pro)

    		Fungal Bacterial IFNAR Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
    Cyclo(L-Phe-L-Pro)
  • HY-N3488
    Isodiospyrin

    		Topoisomerase Bacterial Fungal Infection Cancer
    Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .
    Isodiospyrin
  • HY-N8574
    1-Heptacosanol

    Heptacosan-1-ol

    		 Biochemical Assay Reagents Infection
    1-Heptacosanol (Heptacosan-1-ol) is a long-chain fatty alcohol with antifungal, antibacterial (against Escherichia coli and Staphylococcus aureus), nematicidal, anticancer and antioxidant activities. 1-Heptacosanol can be isolated from leaf extracts of Ficus septica and Lecaniodiscus cupanioides. 1-Heptacosanol not only effectively resists pathogenic fungal infections, but also shows potential against pepper anthracnose in phytopathology. 1-Heptacosanol can be used in the research of fungal infections, cancer and oxidative stress-related diseases .
    1-Heptacosanol
  • HY-N3340
    Macrocarpal I

    		Fungal Infection
    Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC50 value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .
    Macrocarpal I
  • HY-139983
    SDH-IN-1
    1 Publications Verification

    		 Fungal Infection
    SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L) .
    SDH-IN-1
  • HY-N0452R
    Hyperoside (Standard)

    Quercetin 3-O-galactoside (Standard); Quercetin 3-O-β-D-galactopyranoside (Standard)

    		 Reference Standards Influenza Virus Fungal NF-κB Apoptosis Infection Inflammation/Immunology Cancer
    Hyperoside (Standard) is the analytical standard of Hyperoside. This product is intended for research and analytical applications. Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis .
    Hyperoside (Standard)
  • HY-123077
    Norsanguinarine

    		Fungal Infection
    Norsanguinarine, an alkaloid, has antifungal activity against Alternaria brassicicola, Curvularia maculans at 1000 ppm .
    Norsanguinarine
  • HY-B1852
    Sulfometuron-methyl

    		Bacterial Fungal Infection
    Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .
    Sulfometuron-methyl
  • HY-N12697A
    Polycarpine hydrochloride

    		SARS-CoV Virus Protease Influenza Virus Fungal Infection
    Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively .
    Polycarpine hydrochloride
  • HY-N10411
    Morin 3-O-β-D-glucopyranoside

    		Reverse Transcriptase HIV Xanthine Oxidase Infection Cardiovascular Disease Cancer
    Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities .
    Morin 3-O-β-D-glucopyranoside
  • HY-N0540R
    Cynaroside (Standard)
    10+ Cited Publications

    Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)

    		 Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards Infection Cancer
    Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
    Cynaroside (Standard)
  • HY-W012349
    2′-Hydroxychalcone

    		NF-κB Fungal Apoptosis Autophagy Infection Cancer
    2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells . 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp .
    2′-Hydroxychalcone
  • HY-N10229
    Harzianum A

    		Fungal Infection
    Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .
    Harzianum A
  • HY-143335
    Antifungal agent 52

    		Fungal Infection
    Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .
    Antifungal agent 52
  • HY-W150903
    N-Heptyl 4-hydroxybenzoate

    p-Oxybenzoesaureheptylester

    		 Fungal Bacterial Infection
    N-Heptyl 4-hydroxybenzoate (p-Oxybenzoesaureheptylester) is an antimicrobial agent that inhibits S. aureus with MIC of 12.5 μg/mL. N-Heptyl 4-hydroxybenzoate also against plant pathogenic fungi, such as Alternaria brassicicola, F. solani, C. dematium and C. acutatum .
    N-Heptyl 4-hydroxybenzoate
  • HY-N2446
    Kakuol

    		Fungal Infection
    Kakuol is a natural compound with antifungal activity .
    Kakuol
  • HY-156252
    Antifungal agent 75

    		Fungal Infection
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
    Antifungal agent 75
  • HY-113560
    Plipastatin B1

    		Antibiotic Fungal Phospholipase Infection
    Plipastatin B1 is a lipopeptide antibiotic, an inhibitor of phospholipase A2 (PLA2), which has antifungal activity .
    Plipastatin B1
  • HY-148992
    APX879

    		Calcineurin Fungal Infection
    APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity .
    APX879
  • HY-171796
    Bromomonilicin

    		Fungal Infection
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .
    Bromomonilicin
  • HY-156090
    PK-10

    		Mitochondrial Metabolism Fungal Infection
    PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
    PK-10
  • HY-N11706
    β-Cedrene

    (+)-β-Cedrene

    		 Fungal Infection Inflammation/Immunology
    β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM .
    β-Cedrene
  • HY-178162
    CYP51-IN-27

    		Fungal Cytochrome P450 Infection
    CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC50 of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight .
    CYP51-IN-27
  • HY-148054
    Antifungal agent 36

    		Fungal Infection
    Antifungal agent 36 is a potent anti-fungal agent. Antifungal agent 36 shows anti-fungal activity for Basidiomycetes .
    Antifungal agent 36
  • HY-139903
    Antifungal agent 18

    		Fungal Calcineurin p38 MAPK Infection
    Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes .
    Antifungal agent 18
  • HY-186027
    Antifungal agent 152

    		Fungal Infection
    Antifungal agent 152 (Compound 27) is an antifungal agent. Antifungal agent 152 shows antifungal activity against C. neoformans, C. albicans, C. glabrata with MICs of 4 μg/mL, 16 μg/mL, 16 μg/mL, respectively .
    Antifungal agent 152
  • HY-146079
    Antifungal agent 31

    		Fungal Infection
    Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
    Antifungal agent 31
  • HY-155761
    Antifungal agent 71

    		Fungal Infection
    Antifungal agent 71 (compound 6r) is a trifluoromethyl pyrimidine derivative with antifungal activity. Antifungal agent 71 exhibits good in vitro antifungal activity against F. oxysporum, with the EC50 value of 3.61 μg/mL .
    Antifungal agent 71
  • HY-N3088
    Phaseollidin hydrate

    		Fungal Infection
    Phaseollidin hydrate is the hydrate form of the antimicrobial phytoalexin Phaseollidin, which has lower antifungal activity than the original Phaseollidin .
    Phaseollidin hydrate
  • HY-151280
    Antifungal agent 37

    		Bacterial Fungal Infection
    Antifungal agent 37 is a geterocyclic disulfide, with antifungal activity .
    Antifungal agent 37
  • HY-B1852R
    Sulfometuron-methyl (Standard)

    		Bacterial Reference Standards Fungal Infection
    Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .
    Sulfometuron-methyl (Standard)
  • HY-161856
    Antifungal agent 106

    		mTOR Fungal Others
    Antifungal agent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide against Monilinia fructicola. Antifungal agent 106 exhibits antifungal activity with an EC50 value of 11.8 mg/L. It affects hyphal growth by disrupting cell membrane integrity, leading to increased membrane permeability and release of intracellular electrolytes. Antifungal agent 106 can be used in research related to brown rot of stone fruits .
    Antifungal agent 106
  • HY-147919
    Antifungal agent 33

    		Fungal Infection
    Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL .
    Antifungal agent 33
  • HY-156251
    Antifungal agent 74

    		Fungal Infection
    Antifungal agent 74 (compound 3c) is a potent antifungal agent that displays excellent fungicidal activity against C. arachidicola and R. solani. Antifungal agent 74 exerts its fungicidal activity by disrupting steroid biosynthesis and ribosome biogenesis in eukaryotes .
    Antifungal agent 74
  • HY-145407A
    ent-Heronamide C

    		Fungal Infection
    ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .
    ent-Heronamide C
  • HY-145407
    16,17-Dihydroheronamide C

    		Fungal Infection
    16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .
    16,17-Dihydroheronamide C
  • HY-N15326
    Phytoalexine

    		Fungal Infection
    Phytoalexine (Compound 8) is a phytoalexin found in wasabi with antifungal activity against fungi such as Phoma lingam and Phoma wasabiae. Phytoalexine inhibits spore germination and mycelial growth of fungi. Phytoalexine is promising for research of pesticides against plant fungal diseases .
    Phytoalexine
  • HY-156338
    Laccase-IN-2

    		Fungal Infection
    Laccase-IN-2 is an inhibitor of laccase. Laccase-IN-2 has excellent antifungal activity against Magnaporthe oryzae in vitro and in vivo .
    Laccase-IN-2
  • HY-N9930
    Effusanin B

    		Fungal Infection
    Effusanin B (Compound 3) is a diterpenoid can be isolated from Rabdosia effusa (Maxim.) Hara. Effusanin B (Compound 3) has antifungal activity .
    Effusanin B
  • HY-149067
    Antifungal agent 47

    		Fungal Infection
    Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide .
    Antifungal agent 47
  • HY-N14990
    Pneumocandin C0

    		Fungal Infection
    Pneumocandin C0 is the isomer of Pneumocandin B0 (HY-17578) with antifungal activity, which is found by carrying out fermentations of Glarea lozoyensis at a high residual fructose concentration .
    Pneumocandin C0
  • HY-144121
    Ph-Ph+

    		Bacterial Fungal Apoptosis Infection Cancer
    Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities .
    Ph-Ph+
  • HY-163397
    Antibacterial agent 196

    		Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-143236
    DHFR-IN-1

    		Bacterial Fungal Infection
    DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249 .
    DHFR-IN-1
  • HY-146060
    Antibacterial agent 100

    		Bacterial Fungal Infection
    Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans, respectively .
    Antibacterial agent 100
  • HY-158321
    SDH-IN-15

    		Fungal Succinate Dehydrogenase Infection
    SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death .
    SDH-IN-15
  • HY-W037200
    2,3,5-Tri-O-benzyl-D-ribose

    2,3,5-Tri-O-benzyl-D-ribofuranose

    		 Fungal Infection
    2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC50 value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .
    2,3,5-Tri-O-benzyl-D-ribose
  • HY-169684
    Vaccarin C

    		Fungal Infection Cancer
    Vaccarin C (Compound VIII) is a cycloheptapeptide with good antifungal activity against pathogenic fungi and dermatophytes M. audouinii and T. mentagrophytes with MIC values of 6 µg/mL. Vaccarin C also has high cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with IC50 values of 3.35 and 5.72 μM, respectively .
    Vaccarin C

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