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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
382 Results for "
bind DNA
" in MedChemExpress (MCE) Product Catalog:
Products (382)
382 Results for "bind DNA" in MCE Product Catalog:
1253
1253 Publications Verification
LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC50 of 98 nM . LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator .
669
669 Cited Publications
Target:
Forschungsgebiete:
ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .
191
191 Cited Publications
Art. -Nr.: HY-D0814
CAS. Nr.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
191
191 Cited Publications
Art. -Nr.: HY-D2868
CAS. Nr.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
185
185 Cited Publications
Art. -Nr.: HY-D1738
CAS. Nr.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
170
170 Cited Publications
Synonyms: bisBenzimide H 33342; HOE 33342
170
170 Cited Publications
Synonyms: bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
101
Forschungsgebiete:
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
82
82 Cited Publications
Synonyms: 7-Ethyl-10-hydroxycamptothecin
73
73 Cited Publications
Synonyms: Basic Violet 3; Gentian Violet; Methyl Violet 10B
53
53 Cited Publications
Synonyms: Agrept; Agrimycin; Streptomycin A
Category:
44
44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP
Target:
44
44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP sodium
Target:
36
Target:
Forschungsgebiete:
Lavofloxacin lactate ((-)-ofloxacin lactate) is a class of broad-spectrum antimicrobials that can kill or inhibit a variety of bacteria. Lavofloxacin lactate binds to DNA rotase and topoisomerase IV, resulting in blocked DNA replication and repair, thus inhibiting bacterial growth. Lavofloxacin lactate can be used to study resistance mechanisms in bacteria, including studying resistance genes and mutations .
25
25 Cited Publications
Synonyms: bisBenzimide H 33258; H 33258
25
25 Cited Publications
Synonyms: bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
22
22 Cited Publications
Synonyms: GS-6207
Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
22
Lenacapavir (GS-6207) sodium is an HIV-1 capsid inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
14
Novobiocin (Albamycin; Cathomycin) is an orally active antibiotic and Hsp-90 antagonist that also inhibits the Polθ helicase/ATPase domain with IC50 values of 24 μM and 15-17 μM, respectively. Novobiocin binds to Hsp90, GyrB, and POLθ, inhibiting their ATPase activity and ssDNA binding. Novobiocin inhibits molecular chaperone function and DNA repair, and induces apoptosis and genomic instability. Novobiocin exhibits bactericidal and antiparasitic activities. Novobiocin inhibits tumor growth in vivo. Novobiocin is used for research on equine piroplasmosis, ovarian cancer, breast cancer, anthrax, and melioidosis .
14
14 Cited Publications
Synonyms: Albamycin sodium; Cathomycin sodium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
