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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
hypoglycemic agent
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "hypoglycemic agent" in MCE Product Catalog:
13
Category:
Polysaccharides Microorganisms Anti-aging Metabolic Disease Disease Research Fields Saccharides
Target:
12
11
11 Cited Publications
Synonyms: Phenethylbiguanide hydrochloride
Research Areas:
Phenformin (Phenethylbiguanide) hydrochloride is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .
11
Research Areas:
Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .
10
10 Cited Publications
Synonyms: 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride
Target:
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SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides .
4
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Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone .
1
Category:
Metabolic Disease Plants Endogenous metabolite Albizia glaberrima (Schumach. & Thonn.) Benth. Human Gut Microbiota Metabolites Polysaccharides Microorganisms Labiatae Disease Research Fields Saccharides
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1
Target:
Research Areas:
Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells .
1
Cat. No.: HY-126067
CAS No.: 81446-29-9
Category:
other families Hernandia nymphaeifolia (C. Presl) Kubitzki Lignans Phenylpropanoids Plants
Target:
Synonyms: B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14
Target:
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Cat. No.: HY-W008321
CAS No.: 66361-67-9
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Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
Cat. No.: HY-N0821
CAS No.: 63492-69-3
Synonyms: Griffonin
Category:
Natural Products Ranunculaceae Semiaquilegia adoxoides(DC. ) Mak. Plants Disease Research Fields Cancer
Target:
Target:
Research Areas:
Chlorpropamide (Standard) is the analytical standard of Chlorpropamide. This product is intended for research and analytical applications. Chlorpropamide is an oral hypoglycemic agent studied in non-insulin-dependent diabetes mellitus (NIDDM).
Cat. No.: HY-B0089R
CAS No.: 56180-94-0
Synonyms: BAY g 5421 (Standard)
Category:
Target:
Cat. No.: HY-B0401S
CAS No.: 1219794-57-6
Synonyms: (±)-DG5128 free base; DG5128 free base
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Research Areas:
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo .
Cat. No.: HY-16443
CAS No.: 173534-37-7
Target:
Research Areas:
S-4048 is a glucose-6-phosphate translocase modulator and hypoglycemic agent. S-4048 is taken up by hepatocytes via OATP-1 and is rapidly eliminated via the hepatobiliary system in rats. S-4048 blocks glucose-6-phosphate translocase, prevents glucose-6-phosphate from entering the endoplasmic reticulum, and thereby interferes with the glucose-6-phosphatase system (i.e., the final step of hepatic gluconeogenesis and glycogenolysis) to regulate hepatic glucose production. S-4048 completely inhibits glucose production from pyruvate in GLUT2-deficient hepatocytes without affecting the release of cytoplasmic glucose. S-4048 effectively reduces blood glucose levels in rats and has been used in studies related to type 2 diabetes .
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KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
