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immunosuppressant activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (12) Antifolate (2) Apoptosis (3) Autophagy (2) Bacterial (5) Complement System (5) Cyclophilin (4) Cytochrome P450 (1) Deubiquitinase (2) DNA Alkylator/Crosslinker (3) DNA Methyltransferase (2) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (6) Environmental Pollutants (1) FKBP (3) FLT3 (1) Formyl Peptide Receptor (FPR) (1) Fungal (5) Glucocorticoid Receptor (4) HCV (2) Influenza Virus (1) Isotope-Labeled Compounds (6) Molecular Glues (4) NF-κB (2) Parasite (4) Phosphatase (1) Phospholipase (2) Reference Standards (8) SARS-CoV (4) Toll-like Receptor (TLR) (2) Tyrosinase (2)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Infection (14) Inflammation/Immunology (29) Metabolic Disease (5) Neurological Disease (7)

By Targets:

Antibiotic (12)

Antifolate (2)

Apoptosis (3)

Autophagy (2)

Bacterial (5)

Complement System (5)

Cyclophilin (4)

Cytochrome P450 (1)

Deubiquitinase (2)

DNA Alkylator/Crosslinker (3)

DNA Methyltransferase (2)

Drug Derivative (1)

Drug Metabolite (2)

Endogenous Metabolite (6)

Environmental Pollutants (1)

FKBP (3)

FLT3 (1)

Formyl Peptide Receptor (FPR) (1)

Fungal (5)

Glucocorticoid Receptor (4)

HCV (2)

Influenza Virus (1)

Isotope-Labeled Compounds (6)

Molecular Glues (4)

NF-κB (2)

Parasite (4)

Phosphatase (1)

Phospholipase (2)

Reference Standards (8)

SARS-CoV (4)

Toll-like Receptor (TLR) (2)

Tyrosinase (2)

By Research Areas:

Cancer (19)

Cardiovascular Disease (1)

Infection (14)

Inflammation/Immunology (29)

Metabolic Disease (5)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-17420

Cyclophosphamide 65+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Complement System Antibiotic Cyclophilin	Infection Neurological Disease Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-13765

6-Thioguanine 10+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-P1122

Cyclosporin H 3 Publications Verification	Formyl Peptide Receptor (FPR)	Infection Inflammation/Immunology
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B1060

Methylprednisolone succinate sodium 2 Publications Verification Methylprednisolone hydrogen succinate sodium	Glucocorticoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium is a prodrug of Methylprednisolone (HY-B0260) and glucocorticoid with immunosuppressant and anti-inflammatory activity. Methylprednisolone succinate sodium binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. Methylprednisolone succinate sodium alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; suppresses proinflammatory cytokine production and immune cell activation. Methylprednisolone succinate sodium can be used for the research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-B0579S

Cyclosporin A-d4 1 Publications Verification Cyclosporine A-d₄; Ciclosporin A-d₄; CsA-d₄	Isotope-Labeled Compounds Antibiotic Complement System Phosphatase	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-B1900

Methylprednisolone succinate 2 Publications Verification Methylprednisolone hydrogen succinate	Glucocorticoid Receptor Bacterial Toll-like Receptor (TLR) NF-κB	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) is a prodrug of Methylprednisolone (HY-B0260) and glucocorticoid with immunosuppressant and anti-inflammatory activity. Methylprednisolone succinate binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. Methylprednisolone succinate alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; suppresses proinflammatory cytokine production and immune cell activation. Methylprednisolone succinate can be used for the research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury .

HY-12424

Zotarolimus 4 Publications Verification ABT-578; A 179578	Drug Derivative	Cardiovascular Disease Inflammation/Immunology Cancer
Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis .

HY-137301

Mycophenolic acid glucuronide	Drug Metabolite	Cancer
Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research .

HY-W012595

Benzylideneacetone Benzalacetone	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase	Infection Metabolic Disease Inflammation/Immunology
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-B0579R

Cyclosporin A (Standard) Cyclosporine A (Standard); Ciclosporin A (Standard); CsA (Standard)	Molecular Glues Reference Standards Complement System Antibiotic Cyclophilin	Inflammation/Immunology Cancer
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-N6027

Cyclosporin C	Fungal Bacterial	Infection
Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C shows no activity against bacteria or yeasts .

HY-17420S

Cyclophosphamide-d4	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant .

HY-123691

7-O-Demethyl rapamycin	Fungal	Infection Inflammation/Immunology Cancer
7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity .

HY-13765R

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-B1900R

Methylprednisolone succinate (Standard) 1 Publications Verification Methylprednisolone hydrogen succinate (Standard)	Reference Standards Glucocorticoid Receptor Bacterial Toll-like Receptor (TLR) NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Methylprednisolone succinate (Standard) is the analytical standard of Methylprednisolone succinate (HY-B1900). This product is intended for research and analytical applications. Methylprednisolone succinate (Methylprednisolone hydrogen succinate) is a prodrug of Methylprednisolone (HY-B0260) and glucocorticoid with immunosuppressant and anti-inflammatory activity. Methylprednisolone succinate binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. Methylprednisolone succinate alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; suppresses proinflammatory cytokine production and immune cell activation. Methylprednisolone succinate can be used for the research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury .

HY-P991114

Adezkibart	FLT3	Inflammation/Immunology
Adezkibart is a human monoclonal antibody immunosuppressant targeting the human FMS-like tyrosine kinase 3 ligand (FLT3LG). Adezkibart is found in the Chinese hamster ovary cell line CHO-K1, which binds to FLT3LG to block the relevant signaling pathway, inhibits the immune response, and exerts immunosuppressive activity. Adezkibart is promising for research of immune-related diseases .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Reference Standards HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)	Reference Standards FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-B0579S3

Cyclosporin A-13C2,d4 Cyclosporine A-¹³C₂,d₄; Ciclosporin A-¹³C₂,d₄; CsA-¹³C₂,d₄	Isotope-Labeled Compounds	Inflammation/Immunology
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-156520

Immunosuppressant-1	Apoptosis	Inflammation/Immunology
Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 co-stimulated T-cell proliferation. Immunosuppressant-1 has immunosuppressive activity, and induces apoptosis by activating caspase-3 and PARP in activated lymph node cells .

HY-13644A

Gusperimus trihydrochloride Spanidin; NKT-01; BMS181173	Antibiotic	Inflammation/Immunology Cancer
Gusperimus trihydrochloride (Spanidin) is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity .

HY-129664

L 683519	FKBP	Inflammation/Immunology
L 683519, one of the impurities of tacrolimus, is an immunosuppressant. L 683519 can inhibit the activity of FK-506 binding protein .

HY-17420S1

Cyclophosphamide-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-B0579S5

Cyclosporin A-d12 Cyclosporine A-d₁₂; Ciclosporin A-d₁₂; CsA-d₁₂	Isotope-Labeled Compounds Complement System Antibiotic Cyclophilin Molecular Glues	Inflammation/Immunology Cancer
Cyclosporin A-d₁₂ (Cyclosporine A-d₁₂) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S2

Cyclosporin A acetate-d4 Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄; CsA acetate-d₄	Isotope-Labeled Compounds Antibiotic Complement System Molecular Glues Cyclophilin	Inflammation/Immunology
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-107939R

Paramethasone Acetate (Standard)	Glucocorticoid Receptor Reference Standards Cytochrome P450	Neurological Disease Metabolic Disease Inflammation/Immunology
Paramethasone Acetate (Standard) is the analytical standard of Paramethasone Acetate (HY-107939). This product is intended for research and analytical applications. Paramethasone Acetate is an orally active long-acting glucocorticoid. Paramethasone Acetate directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone Acetate suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone Acetate also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone Acetate inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone Acetate can be used in research related to osteoarthritis and endocrinology.

HY-P3107

Homodestcardin	Endogenous Metabolite	Inflammation/Immunology
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC₅₀ value of 0.86 μM .

HY-N12126

Sydowinin B MS-347b	Others	Inflammation/Immunology
Sydowinin B (MS-347b) is a active compound and can be isolated from A. sydowii. Sydowinin B shows has immunosuppressant activity .

HY-105934A

Ketotrexate sodium Emofolin sodium; 5-methyltetrahydrohomofolate sodium; NSC 139490 sodium	Antifolate	Inflammation/Immunology Cancer
Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases .

HY-14518A

Aminopterin sodium 4-Aminofolic acid sodium; APGA sodium	Antifolate	Cancer
Aminopterin sodium (4-Aminofolic acid sodium) is an anti-tumor drug with immunosuppressive activity. Aminopterin sodium blocks the metabolism of folic acid by inhibiting the activity of dihydrofolate reductase, thereby affecting nucleic acid synthesis. Aminopterin sodium is mainly used to inhibit acute lymphoblastic leukemia and certain other types of cancer. Aminopterin sodium is also used clinically as an immunosuppressant to suppress autoimmune diseases .

HY-135766

Colletodiol (+)-Colletodiol	Influenza Virus	Infection
Colletodiol is a fungal metabolite that has been found in D. grovesii and has immunosuppressant and antiviral activities. It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC₅₀s=12 and 5 μg/mL, respectively).1 Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.

HY-W012595R

Benzylideneacetone (Standard) Benzalacetone (Standard)	Reference Standards Endogenous Metabolite Antibiotic Bacterial Tyrosinase Phospholipase	Infection Metabolic Disease Inflammation/Immunology
Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-15091

Anisperimus LF-150195	Endogenous Metabolite	Neurological Disease
Anisperimus (LF-150195) is an immunosuppressant with the activity of enhancing activation-induced T cell death. Anisperimus enhances the sensitivity of T cells to anti-CD95 antibodies and other inducers by promoting the activation of caspase-8 and caspase-10 at the level of the death-inducing signaling complex (DISC). Anisperimus also promotes the development of Foxp3-expressing regulatory CD4 T cells, thereby preventing central nervous system autoimmunity .

HY-137301R

Mycophenolic acid glucuronide (Standard)	Drug Metabolite Reference Standards	Cancer
Mycophenolic acid glucuronide (Standard) is the analytical standard of Mycophenolic acid glucuronide. This product is intended for research and analytical applications. Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research .

HY-N9754

Cyclosporin L	Fungal	Infection Inflammation/Immunology
Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities .

HY-W653745

6-Thioguanine-13C2,15N Thioguanine-¹³C₂,¹⁵N; 2-Amino-6-purinethiol-¹³C₂,¹⁵N	Isotope-Labeled Compounds	Others
6-Thioguanine-13C2,15N (Thioguanine-13C2,15N) is the ¹³C and ¹⁵N labeled 6-Thioguanine (HY-13765). 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Cat. No.	Nom du produit	Target	Research Area

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Complement System Antibiotic Cyclophilin	Infection Neurological Disease Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-P1122

Cyclosporin H 3 Publications Verification	Formyl Peptide Receptor (FPR)	Infection Inflammation/Immunology
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

HY-P3107

Homodestcardin	Endogenous Metabolite	Inflammation/Immunology
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC₅₀ value of 0.86 μM .

HY-N9754

Cyclosporin L	Fungal	Infection Inflammation/Immunology
Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities .

Cat. No.	Nom du produit	Target	Research Area	Image

HY-P991114

Adezkibart	FLT3	Inflammation/Immunology
Adezkibart is a human monoclonal antibody immunosuppressant targeting the human FMS-like tyrosine kinase 3 ligand (FLT3LG). Adezkibart is found in the Chinese hamster ovary cell line CHO-K1, which binds to FLT3LG to block the relevant signaling pathway, inhibits the immune response, and exerts immunosuppressive activity. Adezkibart is promising for research of immune-related diseases .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Structural Classification Productos naturales Microorganisms Classification of Application Fields Anti-aging Inflammation/Immunology Disease Research Fields Source Classification Cancer	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-13765

6-Thioguanine 10+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Productos naturales Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Neurological Disease Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Source Classification	FKBP Parasite Fungal Antibiotic
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-W012595

Benzylideneacetone Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-B0579R

Cyclosporin A (Standard) Cyclosporine A (Standard); Ciclosporin A (Standard); CsA (Standard)	Structural Classification Productos naturales Microorganisms Source Classification	Molecular Glues Reference Standards Complement System Antibiotic Cyclophilin
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-13765R

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Antibiotics Disease Research Source Classification	Reference Standards FKBP Parasite Fungal Antibiotic
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-P3107

Homodestcardin	Microorganisms Classification of Application Fields Cyclopeptides Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC₅₀ value of 0.86 μM .

HY-N12126

Sydowinin B MS-347b	Microorganisms Xanthones Phenols Source Classification	Others
Sydowinin B (MS-347b) is a active compound and can be isolated from A. sydowii. Sydowinin B shows has immunosuppressant activity .

HY-W012595R

Benzylideneacetone (Standard) Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Antibiotic Bacterial Tyrosinase Phospholipase
Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-N9754

Cyclosporin L	Structural Classification Microorganisms Cyclopeptides Source Classification	Fungal
Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities .

Cat. No.	Nom du produit	Chemical Structure

HY-B0579S

Cyclosporin A-d4 1 Publications Verification
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant .

HY-B0579S3

Cyclosporin A-13C2,d4
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-B0579S5

Cyclosporin A-d12
Cyclosporin A-d₁₂ (Cyclosporine A-d₁₂) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S2

Cyclosporin A acetate-d4
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-W653745

6-Thioguanine-13C2,15N
6-Thioguanine-13C2,15N (Thioguanine-13C2,15N) is the ¹³C and ¹⁵N labeled 6-Thioguanine (HY-13765). 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

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