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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
mammary epithelial cells
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "mammary epithelial cells" in MCE Product Catalog:
24
24 Publications Verification
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
24
Category:
Cardiovascular Disease other families Leguminosae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Steroids
Target:
6
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology
Target:
5
5 Cited Publications
Cat. No.: HY-B1858
CAS No.: 50512-35-1
Research Areas:
Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver .
2
2 Cited Publications
Synonyms: β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
1
1 Cited Publications
Cat. No.: HY-175324
CAS No.: 3098773-64-6
Research Areas:
MG-HuR2 is a molecular glue degrader targeting HuR (ELAVL1) with a Kd of 0.2018 μM. MG-HuR2 recruits the E3 ubiquitin ligase RNF126 and induces proteasome-dependent degradation of HuR. MG-HuR2 exhibits a unique biphasic degradation profile. MG-HuR2 reduces the expression of HuR and its downstream targets Bcl2/FOXQ1, inhibits breast cancer cell proliferation, enhances cytotoxicity and apoptosis (apoptosis), and suppresses the growth of 3D breast cancer tumor spheres. MG-HuR2 can be used in studies related to breast cancer and HuR-targeted protein degradation .
1
1 Cited Publications
Cat. No.: HY-N3009
CAS No.: 58822-47-2
Category:
Cardiovascular Disease Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-159059
Purity: 41.20%
1
Synonyms: 15-keto-PGE2
Research Areas:
F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-W007479
CAS No.: 24677-78-9
Cat. No.: HY-159613
CAS No.: 946262-80-2
Target:
Research Areas:
PELP1-IN-1 is a PELP1 inhibitor and an apoptosis inducer with no cytotoxic activity against non-cancer cell lines. PELP1-IN-1 targets wild-type, mutant and drug-resistant ER + breast cancer, and promotes PELP1 degradation through the proteasome pathway. As an analog of SMIP34 (HY-169903), PELP1-IN-1 is applicable to the research of estrogen receptor α-positive breast cancer .
Cat. No.: HY-145268
CAS No.: 863761-17-5
SLEC-11 is a CDH1/E-cadherin modulator that potently inhibits cell death in E-cadherin-deficient cells (EC50=8.2 μM). SLEC-11 can be used to study potential synthetic lethal therapies for gastric cancer .
Cat. No.: HY-145269
CAS No.: 2761538-66-1
AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1 -/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1 -/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations .
Cat. No.: HY-174386
CAS No.: 2761657-21-8
STAT3-IN-43 (Compound K2) is a covalent inhibitor targeting the allosteric site at the junction of the STAT3 coiled-coil domain and DNA-binding domain, with an IC50 of 40.7 μM. STAT3-IN-43 can be used in cancer research .
Cat. No.: HY-174779
Human AREG mRNA encodes the human amphiregulin (AREG) protein, a member of the epidermal growth factor family. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.
Cat. No.: HY-174854
Research Areas:
PySAHA is a multifunctional HDAC inhibitor. PySAHA can degrade intracellular HDAC via a hydrophobic tagging mechanism. PySAHA also possesses photodynamic therapeutic activity and can generate reactive oxygen species under light irradiation. PySAHA can inhibit the proliferation, migration and induce cell apoptosis of breast cancer cells. PySAHA has antitumor activity and can be used in breast cancer research .
Cat. No.: HY-N0260R
CAS No.: 110642-44-9
Synonyms: Epimedin-C (Standard); Baohuoside-VI (Standard)
Target:
Cat. No.: HY-113205S
CAS No.: 2738376-66-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
