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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1104 Results for "
platelets
" in MedChemExpress (MCE) Product Catalog:
Products (1104)
1104 Results for "platelets" in MCE Product Catalog:
242
242 Publications Verification
Synonyms: Coleonol; Colforsin; HL 362
Category:
Plant Terpenoids Coleus forskohlii (Willd.) Briq. Extract Metabolic Disease Diterpenoids Disease Research Fields Inflammation/Immunology Endocrinology Labiatae Extract
Target:
45
45 Cited Publications
Synonyms: PAF (C16)
Category:
Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
39
39 Cited Publications
Synonyms: Acetylsalicylic acid; ASA
Target:
Environmental Pollutants Autophagy NF-κB Apoptosis COX Mitophagy Virus Protease Caspase p38 MAPK
Áreas de investigación:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis .
33
33 Cited Publications
Synonyms: Clopidogrelum
Target:
Áreas de investigación:
Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
33
33 Cited Publications
Referencia número: HY-17459
No. CAS: 120202-66-6
Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate
Target:
Áreas de investigación:
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .
29
29 Cited Publications
Target:
Áreas de investigación:
Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .
26
26 Cited Publications
Synonyms: SB-497115
Áreas de investigación:
Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well .
26
26 Cited Publications
Synonyms: Eltrombopag diethanolamine salt; SB-497115GR
Áreas de investigación:
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag Olamine can be used for the research of cardiovascular. Eltrombopag Olamine also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well .
22
22 Cited Publications
Target:
Áreas de investigación:
IOX2, a chemical probe, is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases .
22
20
Target:
Áreas de investigación:
Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia .
20
20 Cited Publications
Target:
19
19 Cited Publications
Synonyms: Adenine riboside; D-Adenosine
15
15 Cited Publications
Referencia número: HY-N0720
No. CAS: 41060-15-5
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Psoralea corylifolia L. Extract Phenols Polyphenols Disease Research Fields Cancer Isoflavones
Target:
14
13
13 Cited Publications
Synonyms: AZD6140; AR-C 126532XX
Target:
Áreas de investigación:
Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
12
12 Cited Publications
Referencia número: HY-D0199
No. CAS: 16178-48-6
Synonyms: Adenosine diphosphate disodium; ADP disodium
Target:
12
12 Cited Publications
Referencia número: HY-W010918
No. CAS: 58-64-0
Synonyms: Adenosine diphosphate; ADP
Target:
12
12 Cited Publications
Synonyms: SCH 530348
Áreas de investigación:
Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
12
12 Cited Publications
Synonyms: SCH 530348 sulfate
Áreas de investigación:
Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
