36 Results for "

subcellular

" in MedChemExpress (MCE) Product Catalog:
Products (36)

36 Results for "subcellular" in MCE Product Catalog:

7
Mouse IgG1 kappa, Isotype Control
Mouse IgG1 kappa, Isotype Control
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7 Cited Publications
Cat. No.: HY-P99977

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results .
2
Mouse IgG2a kappa, Isotype Control
Mouse IgG2a kappa, Isotype Control
0 Images
2 Cited Publications
Cat. No.: HY-P99978

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Mouse IgG2a kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG2aκ antibodies. Mouse IgG2a kappa, Isotype Control maintains the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG2aκ subtype primary antibody, thus eliminating false positive signals caused by non-specific adsorption in immunological experiments and playing a core role in verifying experimental specificity. Mouse IgG2a kappa, Isotype Control can be applied to immunolocalization experiments such as immunofluorescence staining and immunohistochemistry in the field of cell biology, assisting in protein subcellular localization, cell structure analysis, and other research to ensure the reliability of experimental results .
Biotin-aniline
Biotin-aniline
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Cat. No.: HY-139912
CAS No.: 769933-15-5
Purity:  99.63%
Target:  

DNA Stain Biochemical Assay Reagents

Research Areas:  

Others

Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline is also a novel APEX2 substrate. Biotin-aniline can label proteins via miniSOG. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity .
1,2-Cyclohexylenedinitrilotetraacetic acid
1,2-Cyclohexylenedinitrilotetraacetic acid
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Cat. No.: HY-W102714
CAS No.: 482-54-2
Synonyms: CDTA
Target:  

Biochemical Assay Reagents

Research Areas:  

Neurological Disease

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate .
CY5-Dextran (MW 4000)
CY5-Dextran (MW 4000)
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Cat. No.: HY-112624F1
CY5-Dextran (MW 4000) is a fluorescent dye CY5 (HY-D0821)-labeled Dextran (HY-112624). Dextran-CY5 (MW 4000) can be used to visualize the specific subcellular distribution of dextran at the nanoscale .
icFSP1
icFSP1
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Cat. No.: HY-157068
CAS No.: 1115910-36-5
Purity:  99.94%
Target:  

Ferroptosis Glutathione Peroxidase

Research Areas:  

Cancer

icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation, in synergism with GPX4 inhibition. icFSP1 induces ferroptosis. icFSP1 shows antitumor activity against melanoma. .
Farnesylthioacetic acid
Farnesylthioacetic acid
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Cat. No.: HY-118563
CAS No.: 135784-48-4
Farnesylthioacetic acid is a competitive, non-substrate inhibitor of Prenylcysteine α-carboxyl methyltransferase. It acts as a non-substrate competitive inhibitor of Arabidopsis thaliana Prenylcysteine α-carboxyl methyltransferase and blocks methyltransferase activity. Farnesylthioacetic acid does not inhibit protein farnesyltransferase activity in Arabidopsis. It induces Apoptosis. Farnesylthioacetic acid regulates the subcellular localization of Ras protein, reducing the proportion of cytoplasmic Ras protein without disrupting membrane binding. It enhances ABA-induced seed dormancy, delays seed germination, and promotes maximum stomatal closure at lower exogenous ABA concentrations. Farnesylthioacetic acid can be used in studies related to promyelocytic leukemia .
ABO hydrochloride
ABO hydrochloride
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Cat. No.: HY-115635
CAS No.: 2309172-24-3
Target:  

Annexin A

Research Areas:  

Others

ABO hydrochloride is a potent modulator of ANXA7 as ABO binds to Thr286 of ANXA7 and inhibits its phosphorylation. ABO promotes autophagy via elevation of ANXA7 and triggering ANXA7 subcellular redistribution .
H-FluNox
H-FluNox
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Cat. No.: HY-D2339
CAS No.: 2897614-59-2
H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λex=490 nm, λem=535 nm)
Iodoacetyl-LC-biotin
Iodoacetyl-LC-biotin
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Cat. No.: HY-138065
CAS No.: 93285-75-7
Purity:  99.15%
Target:  

Apoptosis

Research Areas:  

Others

Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes .
O-Desmethyl gefitinib
O-Desmethyl gefitinib
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Cat. No.: HY-100064
CAS No.: 847949-49-9
Purity:  99.40%
Target:  

EGFR

Research Areas:  

Cancer

O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays .
CY5-Dextran (MW60-80k)
CY5-Dextran (MW60-80k)
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Cat. No.: HY-D2465
CY5-Dextran is a fluorescent dye CY5 (HY-D0821)- labeled Dextran (HY-112624). CY5 exhibits a maximal excitation wavelength of 633 nm, and a maximal emission wavelength of 670 nm. Dextran-CY5 can be used to visualize the specific subcellular distribution of dextran at the nanoscale .
BODIPY FL prazosin
BODIPY FL prazosin
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Cat. No.: HY-D1606
CAS No.: 175799-93-6
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes .
FFN 206 dihydrochloride
FFN 206 dihydrochloride
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Cat. No.: HY-110334
CAS No.: 1883548-88-6
Target:  

Fluorescent Dye

Research Areas:  

Others

FFN 206 dihydrochloride, a fluorescent probe, is used as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. FFN 206 dihydrochloride is capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles .
6-Hydroxyindole
6-Hydroxyindole
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Cat. No.: HY-W002438
CAS No.: 2380-86-1
Category:  

Alkaloids Monophenols Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:  

Biochemical Assay Reagents Endogenous Metabolite OAT Ferroptosis

6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases .
(Rac)-AAA
(Rac)-AAA
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Cat. No.: HY-160187A
CAS No.: 3055022-23-3
Target:  

Cadherin MMP Akt FAK ERK NF-κB

Research Areas:  

Cancer

(Rac)-AAA is a regulator and inhibitor targeting GPR75. By blocking the 20-HETE-induced downregulation of GPR75 expression, (Rac)-AAA effectively inhibits the activation of key downstream signaling pathways including EGFR, AKT, NF-κB and FAK. (Rac)-AAA reverses 20-HETE-mediated epithelial-mesenchymal transition, which is specifically characterized by downregulating vimentin (vimentin), upregulating E-Cadherin, as well as reducing MMP-2 activity and cancer cell migration ability. (Rac)-AAA also abolishes the 20-HETE-induced upregulation of HIC-5 expression and anchorage-independent growth, and modulates the subcellular localization of PKC-α and phosphorylated AKT. (Rac)-AAA is investigated in androgen-independent prostate cancer (castration-resistant prostate cancer) .
HSP70-IN-7
HSP70-IN-7
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Cat. No.: HY-175865
Target:  

HSP Apoptosis

Research Areas:  

Cancer

HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer .
Nur77 modulator 1
Nur77 modulator 1
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Cat. No.: HY-131364
CAS No.: 2469975-55-9
Purity:  98.61%
Target:  

Nuclear Hormone Receptor 4A/NR4A Apoptosis

Research Areas:  

Cancer

Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity .
Photoclick sphingosine
Photoclick sphingosine
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Cat. No.: HY-139286
CAS No.: 1823021-14-2
Synonyms: Pacsph; Pacsphingosine (d18:1)
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
CO delivery molecule 1
CO delivery molecule 1
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Cat. No.: HY-144368
CAS No.: 1972616-04-8
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release .
Assay Types