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Results for "

thiol labeling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Amino Acid Derivatives (1) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (25) Caspase (1) DNA Stain (1) Endogenous Metabolite (3) Ferroptosis (3) Fluorescent Dye (30) Glutaminase (1) Isotope-Labeled Compounds (18) Phospholipase (1) Reference Standards (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Infection (2) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136769

Biotin-HPDP 2 Publications Verification	Biochemical Assay Reagents	Others
Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .

HY-138200

Cy5 maleimide 1 Publications Verification Cyanine5 maleimide	DNA Stain Fluorescent Dye	Others
Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).

HY-100041

Bromobimane Maximum Cited Publications 8 Publications Verification Monobromobimane	Fluorescent Dye	Others
Bromobimane (Monobromobimane) is a nonfluorescent and converts into fluorescent products when reacts with thiols. Bromobimane has potential applications in labeling thiols .

HY-D0098

Fluorescein-5-maleimide 5 Publications Verification N-(5-Fluoresceinyl)maleimide	Fluorescent Dye	Others
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .

HY-15941

5(6)-FITC 2 Publications Verification Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers	Fluorescent Dye	Others
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .

HY-D2906

Alexa fluor 647 maleimide	Fluorescent Dye	Others
Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics .

HY-W011500S

TCEP-d16 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds	Others
TCEP-d₁₆ (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-D0807

5-IAF 1 Publications Verification 5-Iodoacetamidofluorescein	Fluorescent Dye	Cancer
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Fluorescent Dye	Others
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

HY-D1605

BODIPY FL L-Cystine 1 Publications Verification	Fluorescent Dye	Others
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dye	Others
Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-D1781

NTPAN-MI	Fluorescent Dye	Others
NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis .

HY-D2381

AF 488 maleimide	Fluorescent Dye	Others
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dye	Others
Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-130509

MTSSL Otmpmms	Biochemical Assay Reagents	Others
MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-N0394S1

L-Cystine-d4 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite Ferroptosis	Others
L-Cystine-d₄ is the deuterium labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-D1261

Naph-EA-mal 1 Publications Verification thiol-green 1	Fluorescent Dye	Others
Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.

HY-135235

Cysteine thiol probe 1 Publications Verification	Fluorescent Dye	Others
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites .

HY-N0394S4

L-Cystine-3,3'-13C2 1 Publications Verification	Ferroptosis Endogenous Metabolite	Others
L-Cystine-3,3'- ¹³C₂ is the ¹³C labeled L-Cystine . L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes .

HY-119493

MSBN	Fluorescent Dye	Others
MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications .

HY-D2498

Cy7 maleimide	Fluorescent Dye	Others
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-N0394S2

L-Cystine-15N2	Endogenous Metabolite Ferroptosis	Others
L-Cystine- ¹⁵N₂ is the ¹⁵N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-W012166

N-Succinimidyl bromoacetate NHS-Bromoacetate	Biochemical Assay Reagents	Infection
N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .

HY-D2448

Cy3-PEG-Thiol	Fluorescent Dye	Cancer
Cy3-PEG-Thiol (Cy3-PEG-SH) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-Thiol is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-D1260

FM-red PSH-red	Fluorescent Dye	Neurological Disease
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-W009299S

Octadecane-1-thiol-d37	Isotope-Labeled Compounds	Others
Octadecane-1-thiol-d₃₇ is the deuterium labeled Octadecane-1-thiol .

HY-W010517S

1-Methyl-5-mercapto-1,2,3,4-tetrazole-d3	Isotope-Labeled Compounds	Others
1-Methyl-5-mercapto-1,2,3,4-tetrazole-d₃ is the deuterium labeled 1-Methyl-1H-tetrazole-5-thiol .

HY-W776833

MTSSL-15N,d15-1 Otmpmms-¹⁵N,d₁₅	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
MTSSL- ¹⁵N,d₁₅-1 (Otmpmms- ¹⁵N,d₁₅) is the deuterium and ¹⁵N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dye	Others
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-D0097

7-Fluorobenzofurazan-4-sulfonic acid ammonium	Fluorescent Dye	Others
7-Fluorobenzofurazan-4-sulfonic acid ammonium is a fluorescent label. 7-Fluorobenzofurazan-4-sulfonic acid ammonium can be used for detecting dissolved thiol-disulfide (e.g., Cys, GSH) .

HY-W615327

Bis-sulfone NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

HY-W011814S

Hexadecane-1-thiol-d33	Isotope-Labeled Compounds	Others
Hexadecane-1-thiol-d₃₃ is the deuterium labeled Hexadecane-1-thiol .

HY-W176660S

3-Methylbut-2-ene-1-thiol-d6 3-Methyl-2-butene-1-thiol-d₆	Isotope-Labeled Compounds	Others
3-Methylbut-2-ene-1-thiol-d₆ is deuterated labeled 3-Methylbut-2-ene-1-thiol.

HY-W1048533H

Biotin-PEG1000-SH Biotin-PEG1000-thiol	Biochemical Assay Reagents	Others
Biotin-PEG1000-SH (Biotin-PEG1000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-118112

4-N-Maleimidobenzoicacid-NHS	Biochemical Assay Reagents	Others
4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents	Others
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-172291

Mal-amide-PEG8-Val-Cit-PAB-PNP	ADC Linker	Cancer
Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.

HY-D1390

Sulfo-Cy5-Mal potassium	Fluorescent Dye	Others
Sulfo-Cy5-Mal potassium is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal potassium specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal potassium can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-D2510

Cy3-PEG2000-SH	Fluorescent Dye	Cancer
Cy3-PEG2000-SH (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG2000-SH is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-129846

IBTP iodide	Biochemical Assay Reagents	Others
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .

HY-W010529S

2-Methylfuran-3-thiol-d3 3-Mercapto-2-methylfuran-d₃	Isotope-Labeled Compounds	Others
2-Methylfuran-3-thiol-d₃ is deuterated labeled 2-Methylfuran-3-thiol.

HY-W1048533C

Biotin-PEG5000-SH Biotin-PEG5000-thiol	Biochemical Assay Reagents	Others
Biotin-PEG5000-SH (Biotin-PEG5000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048533A

Biotin-PEG2000-SH Biotin-PEG2000-thiol,	Biochemical Assay Reagents	Others
Biotin-PEG2000-SH (Biotin-PEG2000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W192474S

1-(Furan-2-yl)ethane-1-thiol-d3 2-(1-Mercaptoethyl)furan-d₃	Isotope-Labeled Compounds	Others
1-(Furan-2-yl)ethane-1-thiol-d₃ is deuterated labeled 1-(Furan-2-yl)ethane-1-thiol.

HY-W1048533E

Biotin-PEG20000-SH Biotin-PEG20000-thiol	Biochemical Assay Reagents	Others
Biotin-PEG20000-SH (Biotin-PEG20000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-130509S

MTSSL-15N Otmpmms-¹⁵N	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
MTSSL- ¹⁵N (Otmpmms- ¹⁵N) is the ¹⁵N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-156559

GlcNAc-SH	Biochemical Assay Reagents	Others
GlcNAc-SH is a thiol-derivatized saccharide that can be used to label Dha to generate glycoprotein mimics .

HY-D0071

N-4-(5,6-Dimethoxy-N-phthalimidinyl)phenylmaleimide	Fluorescent Dye	Others
N-4-(5,6-Dimethoxy-N-phthalimidinyl)phenylmaleimide is a fluorescence reagent for labeling thiol .

HY-W777067

3-Methyl-2-buten-1-yl Thiolacetate-d6	Isotope-Labeled Compounds	Others
3-Methyl-2-buten-1-yl Thiolacetate-d₆ is the deuterium labeled 3-Methyl-2-buten-1-yl Thiolacetate(3-Methyl-2-buten-1-thiol precursor) (HY-W777066).

HY-W699846

5-(Methoxy-d3)-1H-benzo[d]imidazole-2-thiol	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
5-(Methoxy-d₃)-1H-benzo[d]imidazole-2-thiol is the deuterium labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied .

Cat. No.	Product Name	Type

HY-138200

Cy5 maleimide 1 Publications Verification Cyanine5 maleimide	Fluorescent Dye
Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).

HY-100041

Bromobimane Maximum Cited Publications 8 Publications Verification Monobromobimane	Fluorescent Dye
Bromobimane (Monobromobimane) is a nonfluorescent and converts into fluorescent products when reacts with thiols. Bromobimane has potential applications in labeling thiols .

HY-D0098

Fluorescein-5-maleimide

5 Publications Verification

N-(5-Fluoresceinyl)maleimide

Fluorescent Dye

Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .

HY-15941

5(6)-FITC

2 Publications Verification

Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers

Fluorescent Dye

5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .

HY-D2906

Alexa fluor 647 maleimide

Fluorescent Dye

Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics .

HY-D0807

5-IAF 1 Publications Verification 5-Iodoacetamidofluorescein	Fluorescent Dye
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Fluorescent Dye
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

HY-D1605

BODIPY FL L-Cystine 1 Publications Verification	Fluorescent Dye
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-W998680

Fluorescein-maleimide

5-FITC-Maleimide

Fluorescent Dye

Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-D1781

NTPAN-MI	Fluorescent Dye
NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis .

HY-D2381

AF 488 maleimide	Fluorescent Dye
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dye
Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-D1261

Naph-EA-mal

1 Publications Verification

thiol-green 1

Fluorescent Dye

Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.

HY-D2498

Cy7 maleimide	Fluorescent Dye
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-D2448

Cy3-PEG-Thiol	Fluorescent Dye
Cy3-PEG-Thiol (Cy3-PEG-SH) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-Thiol is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-D1260

FM-red PSH-red	Fluorescent Dye
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dye
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-D0097

7-Fluorobenzofurazan-4-sulfonic acid ammonium	Fluorescent Dye
7-Fluorobenzofurazan-4-sulfonic acid ammonium is a fluorescent label. 7-Fluorobenzofurazan-4-sulfonic acid ammonium can be used for detecting dissolved thiol-disulfide (e.g., Cys, GSH) .

HY-D1390

Sulfo-Cy5-Mal potassium	Fluorescent Dye
Sulfo-Cy5-Mal potassium is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal potassium specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal potassium can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-D2510

Cy3-PEG2000-SH	Fluorescent Dye
Cy3-PEG2000-SH (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG2000-SH is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-D0071

N-4-(5,6-Dimethoxy-N-phthalimidinyl)phenylmaleimide	Fluorescent Dye
N-4-(5,6-Dimethoxy-N-phthalimidinyl)phenylmaleimide is a fluorescence reagent for labeling thiol .

HY-D2150

AF 430 maleimide	Fluorescent Dye
AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 maleimide contains maleimide groups that react with thiol groups to form covalent bonds. To achieve specific coupling of dye labels and biomolecules .

HY-D2513

Cy3-PEG10000-SH	Fluorescent Dye
Cy3-PEG10000-SH (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG10000-SH is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-D2511

Cy3-PEG3400-SH	Fluorescent Dye
Cy3-PEG3400-SH (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG3400-SH is absorbed at 550nm and has high solubility and end-group substitution rate .

HY-100041R

Bromobimane (Standard) Monobromobimane (Standard)	Fluorescent Dye
Bromobimane (Standard) is the analytical standard of Bromobimane (HY-100041). This product is intended for research and analytical applications. Bromobimane (Monobromobimane) is a nonfluorescent and converts into fluorescent products when reacts with thiols. Bromobimane has potential applications in labeling thiols .

HY-D3052

5(6)-carbonylated rhodamine 110 maleimide	Fluorescent Dye
5(6)-carbonylated rhodamine 110 maleimide is a maleimide-based fluorescent reagent based on 5(6)-carbonylated rhodamine 110. Maleimide can be labeled by forming a stable thioester structure through an affinity addition reaction with a thiol group (-SH) (Ex/Em = 502/527 nm).

HY-D3056

5(6)-Rhodamine 6G maleimide	Fluorescent Dye
5(6)-Rhodamine 6G maleimide is a maleimide-based fluorescent reagent based on Rhodamine 6G (HY-D0309). Maleimide can be labeled by forming a stable thioester structure through an affinity addition reaction with a thiol group (-SH) (Ex/Em = 526/547 nm).

HY-DY1088

Fluorescein-5-maleimide (solution)

N-(5-Fluoresceinyl)maleimide (solution)

Fluorescent Dye

Fluorescein-5-maleimide (solution) (N-(5-Fluoresceinyl)maleimide (solution)) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .

Solvent and concentration: DMSO: 10 mM

Cat. No.	Product Name	Type

HY-136769

Biotin-HPDP 2 Publications Verification	Biochemical Assay Reagents
Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .

HY-W1048533H

Biotin-PEG1000-SH Biotin-PEG1000-thiol	Biochemical Assay Reagents
Biotin-PEG1000-SH (Biotin-PEG1000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W1048533C

Biotin-PEG5000-SH Biotin-PEG5000-thiol	Biochemical Assay Reagents
Biotin-PEG5000-SH (Biotin-PEG5000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048533A

Biotin-PEG2000-SH Biotin-PEG2000-thiol,	Biochemical Assay Reagents
Biotin-PEG2000-SH (Biotin-PEG2000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048533E

Biotin-PEG20000-SH Biotin-PEG20000-thiol	Biochemical Assay Reagents
Biotin-PEG20000-SH (Biotin-PEG20000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-157919

Biotin-PEAC5-maleimide hydrochloride N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride	Biochemical Assay Reagents
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .

HY-W1048533D

Biotin-PEG10000-SH Biotin-PEG10000-thiol	Biochemical Assay Reagents
Biotin-PEG10000-SH (Biotin-PEG10000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048533I

Biotin-PEG3400-SH Biotin-PEG3400-thiol	Biochemical Assay Reagents
Biotin-PEG3400-SH (Biotin-PEG3400-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048533J

Biotin-PEG40000-SH Biotin-PEG40000-thiol	Biochemical Assay Reagents
Biotin-PEG40000-SH (Biotin-PEG40000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

Cat. No.	Product Name	Chemical Structure

HY-W011500S

TCEP-d16 hydrochloride

1 Publications Verification

TCEP-d₁₆ (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-N0394S1

L-Cystine-d4 1 Publications Verification
L-Cystine-d₄ is the deuterium labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-N0394S4

L-Cystine-3,3'-13C2 1 Publications Verification
L-Cystine-3,3'- ¹³C₂ is the ¹³C labeled L-Cystine . L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes .

HY-N0394S2

L-Cystine-15N2
L-Cystine- ¹⁵N₂ is the ¹⁵N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-W009299S

Octadecane-1-thiol-d37
Octadecane-1-thiol-d₃₇ is the deuterium labeled Octadecane-1-thiol .

HY-W010517S

1-Methyl-5-mercapto-1,2,3,4-tetrazole-d3
1-Methyl-5-mercapto-1,2,3,4-tetrazole-d₃ is the deuterium labeled 1-Methyl-1H-tetrazole-5-thiol .

HY-W776833

MTSSL-15N,d15-1
MTSSL- ¹⁵N,d₁₅-1 (Otmpmms- ¹⁵N,d₁₅) is the deuterium and ¹⁵N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-W011814S

Hexadecane-1-thiol-d33
Hexadecane-1-thiol-d₃₃ is the deuterium labeled Hexadecane-1-thiol .

HY-W176660S

3-Methylbut-2-ene-1-thiol-d6
3-Methylbut-2-ene-1-thiol-d₆ is deuterated labeled 3-Methylbut-2-ene-1-thiol.

HY-W010529S

2-Methylfuran-3-thiol-d3
2-Methylfuran-3-thiol-d₃ is deuterated labeled 2-Methylfuran-3-thiol.

HY-W192474S

1-(Furan-2-yl)ethane-1-thiol-d3
1-(Furan-2-yl)ethane-1-thiol-d₃ is deuterated labeled 1-(Furan-2-yl)ethane-1-thiol.

HY-130509S

MTSSL-15N
MTSSL- ¹⁵N (Otmpmms- ¹⁵N) is the ¹⁵N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .

HY-W777067

3-Methyl-2-buten-1-yl Thiolacetate-d6
3-Methyl-2-buten-1-yl Thiolacetate-d₆ is the deuterium labeled 3-Methyl-2-buten-1-yl Thiolacetate(3-Methyl-2-buten-1-thiol precursor) (HY-W777066).

HY-W699846

5-(Methoxy-d3)-1H-benzo[d]imidazole-2-thiol
5-(Methoxy-d₃)-1H-benzo[d]imidazole-2-thiol is the deuterium labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied .

HY-W700621

TCEP-d12 hydrochloride

TCEP-d₁₂ (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d₁₂) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

HY-B1217S

Bronopol-d4
Bronopol-d₄ is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser ^.

HY-W020050S

Cystamine-d8 dihydrochloride

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride） . Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-B0368S

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-B0368S1

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W1127976S

1,2-Dicarbadodecaborane(12)-1-thiol-10B10
1,2-Dicarbadodecaborane(12)-1-thiol- ¹⁰B₁₀ is a boron-10 labeled 1,2-Dicarbadodecaborane(12)-1-thiol.

HY-W722107

Timonacic-d4
Timonacic-d₄ (1,3-Thiazolidine-4-carboxylic acid-d₄) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .

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