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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
219 Results for "
thymidine
" in MedChemExpress (MCE) Product Catalog:
Products (219)
219 Results for "thymidine" in MCE Product Catalog:
28
87
87 Publications Verification
Synonyms: BrdU; 5-Bromo-2'-deoxyuridine; Bromodeoxyuridine
Forschungsgebiete:
5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells.
40
Target:
Forschungsgebiete:
5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation . 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
30
30 Cited Publications
Art. -Nr.: HY-B0016
CAS. Nr.: 154361-50-9
Forschungsgebiete:
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
12
12 Cited Publications
Synonyms: 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
5
5 Cited Publications
Art. -Nr.: HY-A0063
CAS. Nr.: 183204-72-0
Target:
Forschungsgebiete:
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
5
5 Cited Publications
Art. -Nr.: HY-A0063A
CAS. Nr.: 183204-74-2
Forschungsgebiete:
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
4
Forschungsgebiete:
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .
2
2
2 Cited Publications
Synonyms: Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR
Target:
Forschungsgebiete:
Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .
2
Hycanthone is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC50 of 80 nM against APE1. Hycanthone irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone reduces influenza virus-induced interferon production. Hycanthone exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone can be used in research related to schistosomiasis and cancer .
1
1
1 Cited Publications
Synonyms: TMP disodium salt
1
1 Cited Publications
Art. -Nr.: HY-W113081
CAS. Nr.: 6741-73-7
Synonyms: 1-(4-Thio-beta-D-ribofuranosyl)uracil
Target:
Forschungsgebiete:
4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing .
Art. -Nr.: HY-20140
CAS. Nr.: 40615-39-2
Synonyms: 5'-O-(4,4'-Dimethoxytrityl)thymidine
Forschungsgebiete:
5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides .
Art. -Nr.: HY-B1011
CAS. Nr.: 15176-29-1
Synonyms: EUDR
Target:
Forschungsgebiete:
Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus .
Synonyms: dTDP sodium
Target:
Target:
Forschungsgebiete:
Thymidine 5′-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5′-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug .
Art. -Nr.: HY-W587829
CAS. Nr.: 7236-57-9
Forschungsgebiete:
4-Thiothymidine is a thymidine analog with UVA photosensitizing properties. 4-Thiothymidine incorporates into the DNA of dividing cells via the thymidine kinase-mediated salvage pathway, replacing thymine and sensitizing cells to UVA irradiation, thereby inducing apoptosis. 4-Thiothymidine induces DNA damage upon UVA activation and inhibits DNA replication. 4-Thiothymidine is used in research related to non-melanoma skin malignancies such as squamous cell carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
