90 Results for "

transferrin

" in MedChemExpress (MCE) Product Catalog:
Products (90)

90 Results for "transferrin" in MCE Product Catalog:

18
18 Publications Verification
Cat. No.: HY-13863
CAS No.: 1256493-34-1
Purity:  99.11%
Synonyms: Dyngo-4a
Target:  

Dynamin

Research Areas:  

Neurological Disease

Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
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10
10 Cited Publications
Cat. No.: HY-150287
Synonyms: ITS-G
Insulin-Transferrin-Selenium, 100X (ITS-G) is a mixture of Insulin, transferrin, and sodium selenite that is a general supplement designed for use in classic media such as DMEM, RPMI-1640, and nutrient media such as Ham's F-12, DMEM/F-12. Insulin-Transferrin-Selenium is added to basal medium to reduce the amount of fetal calf serum required to culture cells .
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3
3 Cited Publications
Cat. No.: HY-P3267
CAS No.: 11096-37-0
Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
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1
1 Cited Publications
Cat. No.: HY-131683
CAS No.: 55854-43-8
Purity:  99.87%
Target:  

Dynamin Clathrin

Research Areas:  

Others

ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .
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1
1 Cited Publications
Cat. No.: HY-159569
CAS No.: 1643444-62-5
Research Areas:  

Cancer

TfR-1-IN-1 is a transferrin receptor-1 (TfR-1) inhibitor with tumor cell-specific activity. TfR-1-IN-1 reduces TfR-1 expression, impairs mitochondrial function, induces cell apoptosis, necroptosis and ferroptosis, and increases intracellular iron (II) levels. TfR-1-IN-1 decreases the metabolic activity of cancer cells. TfR-1-IN-1 can be used for the research of ovarian cancer, breast cancer and acute myeloid leukemia .
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1
1 Cited Publications
Cat. No.: HY-16350
CAS No.: 197723-00-5
Synonyms: NKP-1339; IT-139; KP-1339
Research Areas:  

Cancer

BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .
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1
1 Cited Publications
Cat. No.: HY-P71069
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: transferrin receptor protein 1; TR; TfR; Trfr; T9; p90
Species:  
Source:  
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Cat. No.: HY-P9999
CAS No.: 2568868-35-7
Synonyms: RG6102; RO-7126209

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar as well as plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
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Cat. No.: HY-P991047
Synonyms: JR-141 antibody (uncoupled from iduronate 2-sulfatase)

Target:  

Transferrin Receptor

Research Areas:  

Neurological Disease Cancer

Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
Target:  

Ferroportin

Research Areas:  

Others

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
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Cat. No.: HY-P990051
CAS No.: 2653183-66-3
Synonyms: AOC-1001 Antibody; AOC-1044 Antibody

Target:  

Transferrin Receptor

Research Areas:  

Neurological Disease

Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
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Cat. No.: HY-131577A
CAS No.: 42613-33-2
Synonyms: Dispase I
Target:  

Collagen

Research Areas:  

Others

Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
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Cat. No.: HY-P99797
CAS No.: 2140211-48-7
Synonyms: JR-141

Target:  

Transferrin Receptor

Research Areas:  

Neurological Disease

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
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Cat. No.: HY-P3267A
CAS No.: 11096-37-0
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
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Cat. No.: HY-P2297
CAS No.: 344618-30-0
Target:  

Transferrin Receptor

Research Areas:  

Metabolic Disease

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
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Cat. No.: HY-108017
CAS No.: 33725-54-1
Purity:  99.86%
Research Areas:  

Metabolic Disease Cancer

Ferric maltol is an orally active monovalent iron (Fe 3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .
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Cat. No.: HY-150287A
Synonyms: ITS-X
Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) is a cell culture supplement as well as a cell growth and adhesion promoter. Insulin-Transferrin-Selenium-Ethanolamine supports adhesion, pseudopodium formation, pseudopodium elongation and proliferation of adherent cancer cells in serum-free culture systems .
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Cat. No.: HY-P11099
CAS No.: 1254540-73-2
Target:  

Transferrin Receptor

Research Areas:  

Neurological Disease Cancer

Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .
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Cat. No.: HY-A0060
CAS No.: 59937-28-9
Synonyms: NKK 105
Target:  

Lipoxygenase

Research Areas:  

Cancer

Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
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Cat. No.: HY-D2426
Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .
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