Search Result
Results for "
transferrin
" in MedChemExpress (MCE) Product Catalog:
18
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P9999
-
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RG6102; RO-7126209
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Amyloid-β
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Neurological Disease
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Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
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-
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- HY-P3267
-
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Transferrin Receptor
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Others
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Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
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-
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- HY-150287
-
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ITS-G
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Biochemical Assay Reagents
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Endocrinology
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Insulin-Transferrin-Selenium, 100X (ITS-G) is a mixture of Insulin, transferrin, and sodium selenite that is a general supplement designed for use in classic media such as DMEM, RPMI-1640, and nutrient media such as Ham's F-12, DMEM/F-12. Insulin-Transferrin-Selenium is added to basal medium to reduce the amount of fetal calf serum required to culture cells .
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-
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- HY-13863
-
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Dyngo-4a
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Dynamin
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Neurological Disease
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Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
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-
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- HY-P991047
-
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JR-141 antibody (uncoupled from iduronate 2-sulfatase)
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Transferrin Receptor
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Neurological Disease
Cancer
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Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
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-
-
- HY-P10272
-
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PTG-300
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Ferroportin
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Others
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Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
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- HY-P990051
-
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AOC-1001 Antibody; AOC-1044 Antibody
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Transferrin Receptor
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Neurological Disease
Inflammation/Immunology
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Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
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- HY-131683
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ES9-17
1 Publications Verification
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Dynamin
Clathrin
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Others
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ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .
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- HY-131577A
-
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Dispase I
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Collagen
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Others
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Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
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- HY-P99797
-
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JR-141
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Transferrin Receptor
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Neurological Disease
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Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
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- HY-P3267A
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Ferroportin
Transferrin Receptor
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Neurological Disease
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Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
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- HY-P2297
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-
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- HY-108017
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-
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- HY-150287A
-
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ITS-X
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Biochemical Assay Reagents
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Others
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Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) is a cell culture supplement as well as a cell growth and adhesion promoter. Insulin-Transferrin-Selenium-Ethanolamine supports adhesion, pseudopodium formation, pseudopodium elongation and proliferation of adherent cancer cells in serum-free culture systems .
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- HY-P11099
-
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Transferrin Receptor
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Neurological Disease
Cancer
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Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .
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- HY-A0060
-
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NKK 105
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Lipoxygenase
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Cancer
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Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
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-
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- HY-16350
-
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NKP-1339; IT-139; KP-1339
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DNA/RNA Synthesis
Apoptosis
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Cancer
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BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .
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- HY-159569
-
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Transferrin Receptor
Ferroptosis
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Cancer
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TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values of 0.51, 0.46, and 0.48 μM, respectively .
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- HY-D2426
-
|
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Fluorescent Dye
Transferrin Receptor
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Cardiovascular Disease
|
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Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .
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- HY-P2314
-
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Transferrin Receptor
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Cancer
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HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .
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-
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- HY-P991381
-
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PPMX-T003
|
Transferrin Receptor
Reactive Oxygen Species (ROS)
Ferroptosis
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Cancer
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JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .
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- HY-P990130
-
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Transferrin Receptor
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Neurological Disease
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Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
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- HY-P990856
-
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Transferrin Receptor
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Cancer
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Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .
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- HY-P10323
-
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Tumstatin (74-98), human
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Integrin
FAK
mTOR
Apoptosis
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Cancer
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T7 Peptide is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
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- HY-P5533
-
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Biochemical Assay Reagents
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Cancer
|
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CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .
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-
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- HY-P2777
-
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Biochemical Assay Reagents
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
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Ceruloplasmin is a copper-containing multifunctional ferrous oxidase glycoprotein. Ceruloplasmin specifically oxidizes Fe 2+ to Fe 3+, promoting the binding of Fe 3+ to transferrin. Ceruloplasmin can bind to copper ions to prevent the toxicity of free copper to cells. Ceruloplasmin can be used for the research of inflammation, metabolic and neurological disease such as Parkinson’s disease .
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- HY-173444
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HDAC
Transferrin Receptor
Apoptosis
Ferroptosis
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Cancer
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HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research .
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- HY-177564
-
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Del-zota; AOC 1044
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Antibody-Oligonucleotide Conjugates (AOCs)
Transferrin Receptor
Dystrophin
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Neurological Disease
|
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Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .
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- HY-P10323A
-
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Tumstatin (74-98), human TFA
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Integrin
FAK
mTOR
Apoptosis
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Cancer
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T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide TFA inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide TFA induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide TFA is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
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- HY-NP170
-
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HTF (Bovine)
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Biochemical Assay Reagents
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Metabolic Disease
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Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
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- HY-P990791
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Transferrin Receptor
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Infection
Inflammation/Immunology
Cancer
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Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .
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- HY-163549
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-
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- HY-150287B
-
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ITS-A
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Biochemical Assay Reagents
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Others
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Insulin-Transferrin-Selenium-Sodium Pyruvate (ITS-A) is a basal media supplement used to reduce the amount of fetal bovine serum (FBS) used to culture cells.
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- HY-P2297A
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- HY-W581820
-
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Ferrous succinate
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Biochemical Assay Reagents
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Cardiovascular Disease
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Iron(II) succinate (Ferrous succinate) is an orally active and organic acid iron supplement (ferrous salt). Iron(II) succinate improves hematological parameters in iron-deficiency anemia rats, including hemoglobin, red blood cells, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. Iron(II) succinate increases serum ferritin, serum iron levels, and transferrin saturation, while decreasing total iron-binding capacity in iron-deficiency anemia rats. Iron(II) succinate reduces the elevated heart, spleen, and kidney coefficients, and increases the decreased liver coefficient in iron-deficiency anemia rats. Iron(II) succinate replenishes the depleted iron content in the liver and spleen of iron-deficiency anemia rats. Iron(II) succinate can be used for the research of iron-deficiency anemia .
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- HY-172691
-
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Liposome
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Cancer
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DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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- HY-172690
-
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Liposome
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Cancer
|
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DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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- HY-NP0208
-
-
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- HY-NP0205
-
-
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- HY-115832
-
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Transferrin Receptor
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Cancer
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Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .
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- HY-172723A
-
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Liposome
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Cancer
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DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .
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- HY-172724
-
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Liposome
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Cancer
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DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .
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-
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- HY-172722
-
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Liposome
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Cancer
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DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .
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- HY-B0824A
-
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Autophagy
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Others
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(1R)-cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R)-cis-Bifenthrin has a significant impact on the motor function of ParKin-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R)-cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R)-cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R)-cis-Bifenthrin has a lower binding energy with transferrin and transferrin receptor 2, showing stronger interactions. The biological effects of (1R)-cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways .
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- HY-122564
-
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Dynamin
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Others
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Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell [1.
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- HY-A0060R
-
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NKK 105 (Standard)
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Lipoxygenase
Reference Standards
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Cancer
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Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
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- HY-NP0210
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-
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- HY-NP0237
-
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Transferrin Receptor
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Inflammation/Immunology
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Cynomolgus Monkey transferrin is a cynomolgus monkey-derived protein. Transferrin is the transport of iron in the bloodstream. Transferrin can also act as a growth factor .
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- HY-NP0221
-
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Transferrin Receptor
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Inflammation/Immunology
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Rabbit Transferrin is the major iron-containing protein in plasma, responsible for transporting iron absorbed from the digestive tract and iron released by erythrocyte degradation .
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- HY-185100
-
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- HY-172690A
-
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Liposome
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Cancer
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DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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- HY-172689
-
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Liposome
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Cancer
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DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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- HY-108194
-
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Biochemical Assay Reagents
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Others
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CGP 46700 (Compound 49) is an orally active iron chelator, that exhibits high affinity for iron, removes iron from ferritin and human serum transferrin. CGP 46700 promotes iron excretion in a mouse iron overload model .
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- HY-P991838
-
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Transferrin Receptor
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Cancer
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Anti-CD71 Antibody (T56/14) reacts with human CD71. Anti-CD71 Antibody (T56/14) is a non-neutralizing antibody that does not inhibit the binding of transferrin. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-181953
-
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Transferrin Receptor
Ferroptosis
Reactive Oxygen Species (ROS)
Glutathione Peroxidase
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Neurological Disease
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STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 (STIM1)-transferrin receptor 1 (TFR1) protein complex inhibitor with a Kd of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis, lipid peroxidation and ROS production, enhances glutathione peroxidase 4 (GPX4) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage .
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- HY-W581798
-
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Biochemical Assay Reagents
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Metabolic Disease
Cancer
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Iron(II) sulfate hydrate is an iron(II) salt with oral activity, acting as an iron supplier, and is easily oxidized to iron(III) in water. Iron(II) sulfate hydrate induces apoptotic morphological changes in cancer cells, and promotes dose‑dependent iron accumulation in rats. Iron(II) sulfate hydrate can be used in studies of leukemia, breast cancer, iron deficiency, anemia, and restless legs syndrome .
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- HY-147262
-
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Antibody-Oligonucleotide Conjugates (AOCs)
Small Interfering RNA (siRNA)
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Neurological Disease
|
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Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .
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- HY-125188
-
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Parasite
DNA/RNA Synthesis
AMPK
Clathrin
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Infection
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NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
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| Cat. No. |
Product Name |
Type |
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- HY-D2426
-
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Fluorescent Dye
|
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Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .
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| Cat. No. |
Product Name |
Type |
-
- HY-P3267
-
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Biochemical Assay Reagents
|
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Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
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- HY-150287
-
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ITS-G
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Biochemical Assay Reagents
|
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Insulin-Transferrin-Selenium, 100X (ITS-G) is a mixture of Insulin, transferrin, and sodium selenite that is a general supplement designed for use in classic media such as DMEM, RPMI-1640, and nutrient media such as Ham's F-12, DMEM/F-12. Insulin-Transferrin-Selenium is added to basal medium to reduce the amount of fetal calf serum required to culture cells .
|
-
- HY-P3267A
-
|
|
Biochemical Assay Reagents
|
|
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
|
-
- HY-150287A
-
|
ITS-X
|
Biochemical Assay Reagents
|
|
Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) is a cell culture supplement as well as a cell growth and adhesion promoter. Insulin-Transferrin-Selenium-Ethanolamine supports adhesion, pseudopodium formation, pseudopodium elongation and proliferation of adherent cancer cells in serum-free culture systems .
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-
- HY-NP170
-
|
HTF (Bovine)
|
Biochemical Assay Reagents
|
|
Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
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-
- HY-150287B
-
|
ITS-A
|
Biochemical Assay Reagents
|
|
Insulin-Transferrin-Selenium-Sodium Pyruvate (ITS-A) is a basal media supplement used to reduce the amount of fetal bovine serum (FBS) used to culture cells.
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-
- HY-172691
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
|
-
- HY-172690
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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-
- HY-NP0208
-
|
|
Biochemical Assay Reagents
|
|
Chicken Serum Transferrin is a major serum protein in chicken serum. Chicken Serum Transferrin is primarily responsible for transporting iron .
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-
- HY-NP0205
-
|
|
Biochemical Assay Reagents
|
|
Sheep transferrin is a sheep-derived protein that transports iron from the absorption site to cells, where it is stored or utilized .
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-
- HY-172723A
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .
|
-
- HY-172724
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .
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-
- HY-172722
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .
|
-
- HY-NP0210
-
|
|
Biochemical Assay Reagents
|
|
Rat Transferrin is a rat-derived protein. Transferrin is the transport of iron in the bloodstream. Transferrin can also act as a growth factor .
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-
- HY-NP0237
-
|
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Biochemical Assay Reagents
|
|
Cynomolgus Monkey transferrin is a cynomolgus monkey-derived protein. Transferrin is the transport of iron in the bloodstream. Transferrin can also act as a growth factor .
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-
- HY-NP0221
-
|
|
Biochemical Assay Reagents
|
|
Rabbit Transferrin is the major iron-containing protein in plasma, responsible for transporting iron absorbed from the digestive tract and iron released by erythrocyte degradation .
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-
- HY-172690A
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
|
-
- HY-172689
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10272
-
|
PTG-300
|
Ferroportin
|
Others
|
|
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
|
-
- HY-P2297
-
-
- HY-P11099
-
|
|
Transferrin Receptor
|
Neurological Disease
Cancer
|
|
Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .
|
-
- HY-P2314
-
|
|
Transferrin Receptor
|
Cancer
|
|
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .
|
-
- HY-P10323
-
|
Tumstatin (74-98), human
|
Integrin
FAK
mTOR
Apoptosis
|
Cancer
|
|
T7 Peptide is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
|
-
- HY-P5533
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .
|
-
- HY-P10323A
-
|
Tumstatin (74-98), human TFA
|
Integrin
FAK
mTOR
Apoptosis
|
Cancer
|
|
T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide TFA inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide TFA induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide TFA is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
|
-
- HY-P2297A
-
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P9999
-
|
RG6102; RO-7126209
|
Amyloid-β
|
Neurological Disease
|
|
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
|
-
(5)
-
- HY-P991047
-
|
JR-141 antibody (uncoupled from iduronate 2-sulfatase)
|
Transferrin Receptor
|
Neurological Disease
Cancer
|
|
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990051
-
|
AOC-1001 Antibody; AOC-1044 Antibody
|
Transferrin Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
|
-
(5)
-
- HY-P99797
-
|
JR-141
|
Transferrin Receptor
|
Neurological Disease
|
|
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
|
-
(5)
-
- HY-P991381
-
|
PPMX-T003
|
Transferrin Receptor
Reactive Oxygen Species (ROS)
Ferroptosis
|
Cancer
|
|
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .
|
-
(5)
-
- HY-P990130
-
|
|
Transferrin Receptor
|
Neurological Disease
|
|
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
|
-
(5)
-
- HY-P990856
-
|
|
Transferrin Receptor
|
Cancer
|
|
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .
|
-
(5)
-
- HY-P990791
-
|
|
Transferrin Receptor
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .
|
-
(5)
-
- HY-P991838
-
|
|
Transferrin Receptor
|
Cancer
|
|
Anti-CD71 Antibody (T56/14) reacts with human CD71. Anti-CD71 Antibody (T56/14) is a non-neutralizing antibody that does not inhibit the binding of transferrin. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
| Cat. No. |
Product Name |
|
Classification |
-
- HY-172691
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
|
-
- HY-172690
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
|
-
- HY-172723A
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .
|
-
- HY-172724
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .
|
-
- HY-172722
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .
|
-
- HY-185100
-
|
|
|
Aptamers
|
|
Waz sodium is an anti-transferrin receptor aptamer.
|
-
- HY-172689
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
|
-
- HY-147262
-
|
|
|
siRNAs
siRNA drugs
|
|
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .
|
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