34 Results for "

tyrosine hydroxylase inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (34)

34 Results for "tyrosine hydroxylase inhibitor" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-33549
CAS No.: 658-48-0
Synonyms: α-Methyl-p-tyrosine
Target:  

Tyrosine Hydroxylase

Research Areas:  

Neurological Disease Cancer

α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .
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2
2 Cited Publications
Cat. No.: HY-101392
CAS No.: 486-84-0
Purity:  99.91%
Harmane is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .
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2
2 Cited Publications
Cat. No.: HY-101392A
CAS No.: 21655-84-5
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .
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1
1 Cited Publications
Cat. No.: HY-W008452
CAS No.: 70-78-0
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
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1
1 Cited Publications
Cat. No.: HY-W013407
CAS No.: 7361-31-1
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .
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1
1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a Ki value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .
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Cat. No.: HY-W015007
CAS No.: 672-87-7
Target:  

COX

Research Areas:  

Cardiovascular Disease

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .
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Cat. No.: HY-B0927
CAS No.: 118-08-1
Synonyms: (-)-β-Hydrastine; (1R,9S)-β-Hydrastine
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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Cat. No.: HY-B1440
CAS No.: 985-13-7
Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca 2+ channels, reduces intracellular Ca 2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases .
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Cat. No.: HY-123468
CAS No.: 91742-10-8
Purity:  99.03%
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .
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Cat. No.: HY-116195
CAS No.: 126-91-0
Purity:  ≥98.0%
Synonyms: (-)-Linalool
L-Linalool ((-)-Linalool) is a naturally derived monoterpene alcohol with oral activity, possessing neuroprotective, anti-inflammatory, and antioxidant activities. L-Linalool is a 5-HT3 receptor inhibitor and a benzodiazepine-responsive GABAA receptor enhancer. L-Linalool reduces nitrite and lipid peroxidation in the brain and partially prevents the decrease of striatal dopamine, DOPAC, and HVA. L-Linalool exhibits neuroprotective effects in hemiparkinsonian rats, cortical oxygen-glucose deprivation injury, and Alzheimer's disease models. L-Linalool prevents the decrease in tyrosine hydroxylase and dopamine transporter expression. L-Linalool can be used in research related to diseases such as Parkinson's disease and Alzheimer's disease .
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Cat. No.: HY-33549R
CAS No.: 658-48-0
Synonyms: α-Methyl-p-tyrosine (Standard)
α-Methyl-p-tyrosine (Standard) is the analytical standard of α-Methyl-p-tyrosine. This product is intended for research and analytical applications. α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .
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Cat. No.: HY-112348
CAS No.: 92564-34-6
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .
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Cat. No.: HY-170738
CAS No.: 34200-97-0
Research Areas:  

Neurological Disease

Oudenone derivative-1 potassium is a derivative of Oudenone. Oudenone, a metabolite of the fungus, is a catecholamine biosynthesis and tyrosine hydroxylases inhibitor .
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Cat. No.: HY-156069
CAS No.: 41768-12-1
Target:  

COMT

Research Areas:  

Neurological Disease Cancer

Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC50 = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase .
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Cat. No.: HY-175149
CAS No.: 170795-16-1
Target:  

Tyrosine Hydroxylase

Research Areas:  

Metabolic Disease

2-Fluorodeoxyarbutin, a derivative of Deoxyarbutin (HY-B1461), is a tyrosine hydroxylase and dopa oxidase inhibitor. 2-Fluorodeoxyarbutin inhibits melanin synthesis in intact melanocytes. 2-Fluorodeoxyarbutin can be used for the strudy of skin lightening or for ameliorating hyperpigmented lesions .
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Cat. No.: HY-W015007R
CAS No.: 672-87-7
Target:  

Reference Standards COX

Research Areas:  

Cardiovascular Disease

Metyrosine (Standard) is the analytical standard of Metyrosine. This product is intended for research and analytical applications. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .
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Cat. No.: HY-N3548
CAS No.: 1585-68-8
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .
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Cat. No.: HY-W015007S
CAS No.: 1994331-23-5
Metyrosine- 13C9, 15N,d7 is the deuterium, 13C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .
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Cat. No.: HY-W008452S
CAS No.: 2483735-06-2
H-Tyr(3-I)-OH- 13C6 is the 13C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
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