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Results for "

vascular dysfunction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VEGFR (1) Adrenergic Receptor (9) Akt (3) AMPK (2) Androgen Receptor (2) Apoptosis (2) Autophagy (4) Biochemical Assay Reagents (1) Cadherin (1) Calcium Channel (3) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Endothelin Receptor (2) Environmental Pollutants (1) ERK (2) Flavivirus (1) FOXO (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) Keap1-Nrf2 (1) Mineralocorticoid Receptor (2) Mitochondrial Metabolism (1) MMP (1) NADPH Oxidase (1) NF-κB (3) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) PI3K (1) PKC (2) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (ROS) (3) Reference Standards (4) SARS-CoV (1) STAT (1) Tie (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (20) Endocrinology (11) Infection (4) Inflammation/Immunology (7) Metabolic Disease (10) Neurological Disease (2)

By Targets:

VEGFR (1)

Adrenergic Receptor (9)

Akt (3)

AMPK (2)

Androgen Receptor (2)

Apoptosis (2)

Autophagy (4)

Biochemical Assay Reagents (1)

Cadherin (1)

Calcium Channel (3)

Cytochrome P450 (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Endogenous Metabolite (3)

Endothelin Receptor (2)

Environmental Pollutants (1)

ERK (2)

Flavivirus (1)

FOXO (1)

Insulin Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JAK (1)

Keap1-Nrf2 (1)

Mineralocorticoid Receptor (2)

Mitochondrial Metabolism (1)

MMP (1)

NADPH Oxidase (1)

NF-κB (3)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

PKC (2)

Protease Activated Receptor (PAR) (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (4)

SARS-CoV (1)

STAT (1)

Tie (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (20)

Endocrinology (11)

Infection (4)

Inflammation/Immunology (7)

Metabolic Disease (10)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: VEGFR VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0561

Spironolactone Maximum Cited Publications 7 Publications Verification SC9420	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-12717

Phentolamine 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Phentolamine is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine reduces systemic vascular resistance and increases cardiac output. Phentolamine improves erectile dysfunction. Phentolamine can be used for the research of erectile dysfunction .

HY-N0563

Alizarin 1 Publications Verification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450	Cardiovascular Disease Cancer
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-B0362A

Phentolamine mesylate 5+ Cited Publications Phentolamine methanesulfonate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-N11848

D-Glucosamine 6-phosphate Glucosamine-6-phosphate; D-GlcN-6-P	Endogenous Metabolite	Metabolic Disease
D-Glucosamine 6-phosphate is an endogenous metabolite that can be synthesized by glutamine fructose-6-phosphate amidotransferase (GFAT). D-Glucosamine 6-phosphate can be used for the research of diabetes mellitus .

HY-125864B

Murine Fibrinogen	MMP Cadherin	Cardiovascular Disease Neurological Disease
Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .

HY-12717A

Phentolamine hydrochloride 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction .

HY-A0066A

Tolazoline hydrochloride Imidaline hydrochloride; NSC35110 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-107586

Demethylasterriquinone B1 DAQ B1; L-783281; Dimethylasterriquinone	Insulin Receptor Akt NO Synthase NADPH Oxidase JAK STAT FOXO DNA/RNA Synthesis ERK Flavivirus	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology
Demethylasterriquinone B1 (DAQ B1; L-783281) is an orally active insulin receptor (insulin receptor) agonist and AKT activator. By activating AKT, Demethylasterriquinone B1 upregulates the expression and activity of eNOS to increase NO production, while downregulating the expression of the NADPH oxidase subunit p22phox to reduce oxidative stress and improve vascular endothelial dysfunction in hypertensive rats. Demethylasterriquinone B1 combind with an AKT inhibitor targets the insulin signaling pathway to activate two antiviral pathways, RNA interference and JAK/STAT, in mosquitoes, thereby reducing Zika virus infection .

HY-A0066

Tolazoline Imidaline; NSC35110	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tolazoline (Imidaline) is an α-adrenergic receptor antagonist. Tolazoline inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-P10580

Vasculotide	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock .

HY-N11722

Panduratin A	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase	Infection Inflammation/Immunology Endocrinology
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-P10580A

Vasculotide TFA	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide TFA, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide TFA ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide TFA promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide TFA protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide TFA decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock .

HY-W023144

Tris(1-chloro-2-propyl) phosphate Tris(1-chloropropan-2-yl) phosphate	Environmental Pollutants Apoptosis DNA/RNA Synthesis Reactive Oxygen Species (ROS) Mitochondrial Metabolism Biochemical Assay Reagents	Cardiovascular Disease
Tris (1-chloro-2-propyl) phosphate (Tris (1-chloropropan-2-yl) phosphate) is a chlorinated organophosphate flame retardant. Tris (1-chloro-2-propyl) phosphate induces DNA damage, elevates intracellular ROS levels, and triggers oxidative stress. Tris (1-chloro-2-propyl) phosphate disrupts mitochondrial membrane potential, leading to mitochondrial dysfunction. Tris (1-chloro-2-propyl) phosphate can trigger cell Apoptosis. Tris (1-chloro-2-propyl) phosphate reduces the survival rate of umbilical vein endothelial cells at relatively high concentrations .

HY-N11848R

D-Glucosamine 6-phosphate (Standard) Glucosamine-6-phosphate (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
D-Glucosamine 6-phosphate (Glucosamine-6-phosphate; D-GlcN-6-P) (Standard) is an analytical standard for D-Glucosamine 6-phosphate. This product is used for research and analytical applications. D-Glucosamine 6-phosphate is a phosphorylated amino sugar synthesized by glutamine fructose-6-phosphate aminotransferase (GFAT). The expression level of D-Glucosamine 6-phosphate is regulated by glucose and glutamine concentrations .

HY-174829

7,4'-Dimethoxy-3-hydroxyflavone	Protease Activated Receptor (PAR) NF-κB Reactive Oxygen Species (ROS) Calcium Channel Akt ERK p38 MAPK PKC	Cardiovascular Disease Metabolic Disease
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC₅₀ of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, Ca ²⁺/protein kinase C, Akt, ERK and p38. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice. 7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time ^[1][2].

HY-P3199

PKCβII Peptide Inhibitor I	PKC	Inflammation/Immunology
PKCβII Peptide Inhibitor I is a PKCβII inhibitor. PKCβII Peptide Inhibitor I shows cardioprotective effects in rat cardiac Ischemia/reperfusion injury model. PKCβII Peptide Inhibitor I also prevents vascular endothelial dysfunction .

HY-10383

J-104132	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
J-104132 (L-753037) is a potent, orally active, selective and competitive ETA/ETB receptor antagonist with K_i of 0.034 nM for ETA and 0.104 nM for ETB receptors. J-104132 inhibits Endothelin-1 (ET-1) (HY-P71446)-induced signaling and vascular contractions in vitro. J-104132 alleviates hypertension, vascular remodeling, and diabetic endothelial dysfunction in vivo by dual ETA/ETB blockade. J-104132 can be used for research on diabetic vascular complications ^[1][3].

HY-12717AS

Phentolamine-d4 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-134314

8-Nitro-cGMP	Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice .

HY-B0561S4

Spironolactone-d6-1	Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Cancer
Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-B0362AR

Phentolamine mesylate (Standard) Phentolamine methanesulfonate (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phentolamine (mesylate) (Standard) is the analytical standard of Phentolamine (mesylate). This product is intended for research and analytical applications. Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-19420

UK 357903	Phosphodiesterase (PDE)	Others
UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC₅₀s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction .

HY-A0066R

Tolazoline (Standard) Imidaline (Standard); NSC35110 (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Endocrinology
Tolazoline (Standard) is the analytical standard of Tolazoline. This product is intended for research and analytical applications. Tolazoline (Imidaline) is an α-adrenergic receptor antagonist. Tolazoline inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-A0066AR

Tolazoline hydrochloride (Standard) Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-167153

PNA5	Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library	1,656 compounds
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1,656 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Ion Channel Compound Library

1,656 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,656 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P10580

Vasculotide	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock .

HY-P10580A

Vasculotide TFA	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide TFA, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide TFA ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide TFA promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide TFA protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide TFA decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock .

HY-P3199

PKCβII Peptide Inhibitor I	PKC	Inflammation/Immunology
PKCβII Peptide Inhibitor I is a PKCβII inhibitor. PKCβII Peptide Inhibitor I shows cardioprotective effects in rat cardiac Ischemia/reperfusion injury model. PKCβII Peptide Inhibitor I also prevents vascular endothelial dysfunction .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-167153

PNA5	Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-N11848

D-Glucosamine 6-phosphate Glucosamine-6-phosphate; D-GlcN-6-P	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Monosaccharides Source Classification	Endogenous Metabolite
D-Glucosamine 6-phosphate is an endogenous metabolite that can be synthesized by glutamine fructose-6-phosphate amidotransferase (GFAT). D-Glucosamine 6-phosphate can be used for the research of diabetes mellitus .

HY-A0066A

Tolazoline hydrochloride Imidaline hydrochloride; NSC35110 hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Alpinia officinarum Hance Plants Disease Research Fields Endocrinology Source Classification Zingiberaceae	Adrenergic Receptor
Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-N11722

Panduratin A	Structural Classification Phenols Polyphenols Boesenbergia rotunda Plants Source Classification Zingiberaceae	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-N11848R

D-Glucosamine 6-phosphate (Standard) Glucosamine-6-phosphate (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Monosaccharides Source Classification	Endogenous Metabolite Reference Standards
D-Glucosamine 6-phosphate (Glucosamine-6-phosphate; D-GlcN-6-P) (Standard) is an analytical standard for D-Glucosamine 6-phosphate. This product is used for research and analytical applications. D-Glucosamine 6-phosphate is a phosphorylated amino sugar synthesized by glutamine fructose-6-phosphate aminotransferase (GFAT). The expression level of D-Glucosamine 6-phosphate is regulated by glucose and glutamine concentrations .

HY-A0066AR

Tolazoline hydrochloride (Standard) Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)	Alkaloids Other Alkaloids Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Reference Standards Adrenergic Receptor
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

Cat. No.	Product Name	Chemical Structure

HY-12717AS

Phentolamine-d4 hydrochloride
Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

Phentolamine-d4 hydrochloride

Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-B0561S4

Spironolactone-d6-1
Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

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vascular dysfunction

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