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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
working
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "working" in MCE Product Catalog:
20
Target:
Forschungsgebiete:
Sodium nitroprusside (Ro 21-2498) is a potent vasodilator working through releasing NO spontaneously in blood.
1
1 Cited Publications
Art. -Nr.: HY-P1932
CAS. Nr.: 186901-48-4
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Forschungsgebiete:
1
1 Cited Publications
Art. -Nr.: HY-160505
CAS. Nr.: 2648837-04-9
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Forschungsgebiete:
RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .
1
1 Cited Publications
Art. -Nr.: HY-W089353
CAS. Nr.: 194235-40-0
Art. -Nr.: HY-17549
CAS. Nr.: 63547-13-7
Synonyms: CRL 40028
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Forschungsgebiete:
Adrafinil (CRL 40028) is an orally active vigilance promoting agent. Adrafinil enhances central noradrenergic transmission, improves spontaneous activity, exploratory behavior, discriminative learning ability and response motivation, but impairs visuospatial working memory. Adrafinil antagonizes Prazosin (HY-B0193)-induced hypoactivity and hypothermia, exerts anticonvulsant effects, and induces sustained enhancement of high-frequency electrocortical activity. Adrafinil can be used for research on decreased alertness and specific cognitive deficits .
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Art. -Nr.: HY-D0876
CAS. Nr.: 68189-43-5
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Forschungsgebiete:
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .
Art. -Nr.: HY-D2299
CAS. Nr.: 2653341-17-2
Art. -Nr.: HY-P990781
CAS. Nr.: 2415439-63-1
Synonyms: SM03
Forschungsgebiete:
Art. -Nr.: HY-128174
CAS. Nr.: 69954-48-9
Synonyms: Beta-CCM; Ro 22-7497
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Forschungsgebiete:
β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and proconvulsant effects. β-CCM enhances emotional reactivity and reduces vulnerability to interference in spatial working memory tasks. β-CCM can be used for research on anxiety-related disorders .
Art. -Nr.: HY-170409
CAS. Nr.: 1195795-81-3
Forschungsgebiete:
Neurological Disease Metabolic Disease Inflammation/Immunology
BNN27 is a blood-brain barrier-penetrant, selective NGF receptor (TrkA and p75NTR) activator. BNN27 activates ERK1/2/AKT. BNN27 enhances NGF-induced differentiation/axonal growth and inhibits JNK after NGF withdrawal. BNN27 reduces Amyloid-β plaques, gliosis, and pro-inflammatory cytokines, and rescues synaptic/cholinergic deficits, neurogenesis, and working memory. BNN27 can be used in research on Alzheimer's disease, amyotrophic lateral sclerosis, diabetic retinopathy, inflammatory hyperalgesia, anxiety disorders, and multiple sclerosis .
Art. -Nr.: HY-W770410
CAS. Nr.: 2748638-71-1
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Forschungsgebiete:
PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility .
Art. -Nr.: HY-59201A
CAS. Nr.: 848591-90-2
Forschungsgebiete:
A-582941 dihydrochloride is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with Ki values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 dihydrochloride exhibits agonistic activity at 5-HT3 receptors, with a Ki of 150 nM. A-582941 dihydrochloride triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 dihydrochloride is applicable for the research of Alzheimer's disease and schizophrenia .
Art. -Nr.: HY-120657S
CAS. Nr.: 2704278-85-1
Art. -Nr.: HY-147877
CAS. Nr.: 2304527-20-4
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Forschungsgebiete:
Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .
Art. -Nr.: HY-14824A
CAS. Nr.: 876170-44-4
Synonyms: ABT 894 benzenesulfonate
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Forschungsgebiete:
Sofinicline benzenesulfonate (ABT 894 benzenesulfonate) is a novel nicotinic acetylcholine receptor agonist, specifically acting on the α4β2 subtype of nAChR (IC50=0.1 nM). Sofinicline benzenesulfonate has the potential to improve cognitive function, including attention, memory and working memory. Sofinicline benzenesulfonate can be used in studies of attention deficit, hyperactivity disorder (ADHD) .
Art. -Nr.: HY-135493
CAS. Nr.: 143137-35-3
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Forschungsgebiete:
RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
