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Cat. No.: HY-N19133

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Shearinine A

Name: Shearinine A
Brand: MedChemExpress
SKU: HY-N19133
Availability: PreOrder

(Synonyms: (+)-Shearinine A)

Shearinine A ((+)-Shearinine A) is an orally active insecticidal indole alkaloid present in the sclerotioid ascostromata of the endophytic fungi Aspergillus fumigatus GCV-12 and Eupenicillium shearii. Shearinine A inhibits methicillin-resistant Staphylococcus aureus (MRSA). Shearinine A exhibits biological activity against corn earworms and dried fruit beetles. Shearinine A can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 163136-24-1
Formula: C₃₇H₄₅NO₅
Molecular Weight:583.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Shearinine A Chemical Structure

CAS No.: 163136-24-1

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Shearinine A (compound 1) (25.0 μg/mL) inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 25.0 μg/mL^[1].
Shearinine A (compound 1) undergoes 15% autoxidation to its dioxoindole analog when stirred in methanol in air at room temperature for 72 hours^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Shearinine A (compound 1) (100 ppm; dietary; continuous feeding) causes an 89% reduction in weight gain of Helicoverpa zea larvae relative to controls^[2].
Shearinine A (100 ppm; dietary; continuous feeding) causes a 69% reduction in feeding rate and a 48% reduction in weight gain of Carpophilus hemipterus larvae relative to controls^[2].
Shearinine A (2 μg/insect; topical; single application) causes an 80% reduction in weight gain of first instar Helicoverpa zea larvae relative to controls^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 163136-24-1
Molecular Weight 583.77
Formula C₃₇H₄₅NO₅
SMILES

O[C@]12C=3[C@]4(O[C@](C(C)(C)O4)(C(=O)C3)[H])CC[C@]1(C)[C@@]5(C)C6=C(C[C@@]5(CC2)[H])C=7C(N6)=CC8=C(C7)C[C@]9(C8=CC(C)(C)OC9(C)C)[H]
Synonyms

(+)-Shearinine A
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Microorganisms
Eupenicillium shearii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bo H, et al. Indole-Diterpenoids with Anti-MRSA Activity from the Endophytic Fungus Aspergillus fumigatus. Chemistry of Natural Compounds. 2025;61:827-830.

[2]. Belofsky GN, et al. Antiinsectan alkaloids: Shearinines A-C and a new paxilline derivative from the ascostromata of Eupenicillium shearii. Tetrahedron. 1995;51(14):3959-3968.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Shearinine A

All Antibiotic Isoforms