2. Anti-infection
  3. Antibiotic Bacterial
  4. Shearinine A

Shearinine A ((+)-Shearinine A) is an orally active insecticidal indole alkaloid present in the sclerotioid ascostromata of the endophytic fungi Aspergillus fumigatus GCV-12 and Eupenicillium shearii. Shearinine A inhibits methicillin-resistant Staphylococcus aureus (MRSA). Shearinine A exhibits biological activity against corn earworms and dried fruit beetles. Shearinine A can be used in studies related to bacterial infections.

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Shearinine A

Shearinine A Chemical Structure

CAS No. : 163136-24-1

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Shearinine A Related Antibodies

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Description

Shearinine A ((+)-Shearinine A) is an orally active insecticidal indole alkaloid present in the sclerotioid ascostromata of the endophytic fungi Aspergillus fumigatus GCV-12 and Eupenicillium shearii. Shearinine A inhibits methicillin-resistant Staphylococcus aureus (MRSA). Shearinine A exhibits biological activity against corn earworms and dried fruit beetles. Shearinine A can be used in studies related to bacterial infections[1][2].

In Vitro

Shearinine A (compound 1) (25.0 μg/mL) inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 25.0 μg/mL[1].
Shearinine A (compound 1) undergoes 15% autoxidation to its dioxoindole analog when stirred in methanol in air at room temperature for 72 hours[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Shearinine A Related Antibodies
In Vivo

Shearinine A (compound 1) (100 ppm; dietary; continuous feeding) causes an 89% reduction in weight gain of Helicoverpa zea larvae relative to controls[2].
Shearinine A (100 ppm; dietary; continuous feeding) causes a 69% reduction in feeding rate and a 48% reduction in weight gain of Carpophilus hemipterus larvae relative to controls[2].
Shearinine A (2 μg/insect; topical; single application) causes an 80% reduction in weight gain of first instar Helicoverpa zea larvae relative to controls[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

583.77

Formula

C37H45NO5
CAS No.
SMILES

O[C@]12C=3[C@]4(O[C@](C(C)(C)O4)(C(=O)C3)[H])CC[C@]1(C)[C@@]5(C)C6=C(C[C@@]5(CC2)[H])C=7C(N6)=CC8=C(C7)C[C@]9(C8=CC(C)(C)OC9(C)C)[H]
Structure Classification
Initial Source

Eupenicillium shearii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Shearinine A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Shearinine A163136-24-1(+)-Shearinine AAntibioticBacterialEupenicillium sheariimethicillin-resistant Staphylococcus aureusHelicoverpa zeaCarpophilus hemipterusAspergillus fumigatus GCV-12Inhibitorinhibitorinhibit

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