2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Sildenafil Mesylate

Sildenafil Mesylate is an orally active and selective phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Mesylate can be used in studies of erectile dysfunction and cancer.

For research use only. We do not sell to patients.

CAS No. : 1308285-21-3

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Sildenafil Mesylate Related Antibodies

Top Publications Citing Use of Products

    Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253.  [Abstract]

    The mean velocities of immature BMDCs in 3D collagen gel treated with vehicle, 30 μM Sildenafil or sildenafil plus 10 μM ODQ. From left to right, n = 98, 79, 126 cells.

    Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253.  [Abstract]

    Tumour growth and survival curves of MC38-Pde5−/− tumour-bearing mice treated with vehicle or Sildenafil (20 μg/g).

    Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2023 Jan;11(1):e15549.  [Abstract]

    The index of cell proliferation in the lungs is significantly reduced in hypoxic mice that received CL316243, Sildenafil (50 mg/kg), or riociguat compared with hypoxic mice treated with vehicle.

    Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860.  [Abstract]

    P62 mRNA levels in NHF upon Sildenafil treatment (100 μM, 6 h) in presence or absence of ConA (2.5 nM, 2 h).

    Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860.  [Abstract]

    Analysis of the autophagic flux in NHF upon treatment with Sildenafil (100 μM, 24 h) in presence or absence of ConA (2.5 nM; 2 h).

    View All Phosphodiesterase (PDE) Isoform Specific Products:

    View All Isoforms
    PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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    Description

    Sildenafil Mesylate is an orally active and selective phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Mesylate can be used in studies of erectile dysfunction and cancer[1].

    Molecular Weight

    570.68

    Formula

    C23H34N6O7S2
    CAS No.
    SMILES

    CCOC1=C(C(N2)=NC3=C(N(C)N=C3CCC)C2=O)C=C(S(=O)(N4CCN(C)CC4)=O)C=C1.CS(=O)(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Sildenafil Mesylate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sildenafil1308285-21-3Phosphodiesterase (PDE)erectile dysfunctioncancerInhibitorinhibitorinhibit

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