Sildenafil Mesylate
Based on 13 publication(s) in Google Scholar
Sildenafil Mesylate is an orally active and selective phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Mesylate can be used in studies of erectile dysfunction and cancer.
For research use only. We do not sell to patients.
- CAS No.: 1308285-21-3
- Formula: C23H34N6O7S2
- Molecular Weight:570.68
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Sildenafil Mesylate
More- Nature. 2025 Sep;645(8079):244-253. [Abstract]
- Phytomedicine. 2025 Sep 25:148:157334. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Br J Pharmacol. 2024 Dec;181(23):4920-4936. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Bioeng Transl Med. 2023 Jul 2;8(5):e10568. [Abstract]
- Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]
- ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167018. [Abstract]
- J Nat Med. 2025 Sep;79(5):1154-1166. [Abstract]
- Biochem Biophys Res Commun. 2021 Apr 2:547:9-14. [Abstract]
- Physiol Rep. 2023 Jan;11(1):e15549. [Abstract]
- Biomed Chromatogr. 2024 Jun 5:e5925. [Abstract]
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Biological Activity
Chemical Information
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CAS No. 1308285-21-3
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Molecular Weight 570.68
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Formula C23H34N6O7S2
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SMILES
CCOC1=C(C(N2)=NC3=C(N(C)N=C3CCC)C2=O)C=C(S(=O)(N4CCN(C)CC4)=O)C=C1.CS(=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2025 Sep;645(8079):244-253. PMID: 40562926
Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]
The mean velocities of immature BMDCs in 3D collagen gel treated with vehicle, 30 μM Sildenafil or sildenafil plus 10 μM ODQ. From left to right, n = 98, 79, 126 cells.
Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]
Tumour growth and survival curves of MC38-Pde5−/− tumour-bearing mice treated with vehicle or Sildenafil (20 μg/g).
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Phytomedicine
Crocin inhibits neutrophil migration and activation to treat hypoxic pulmonary hypertension through targeting HCK. [Abstract]2025 Sep 25:148:157334. PMID: 41043333 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Br J Pharmacol
An adenosinergic positive feedback loop extends pharmacological cardioprotection duration. [Abstract]2024 Dec;181(23):4920-4936. PMID: 39256947 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Bioeng Transl Med
Ultrasound-targeted microbubble destruction mediates PDE5i/NO integration for cavernosum remodeling and penile rehabilitation. [Abstract]2023 Jul 2;8(5):e10568. PMID: 37693040 -
Int J Mol Sci
A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts. [Abstract]2022 Jun 20;23(12):6860. PMID: 35743299
Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]
P62 mRNA levels in NHF upon Sildenafil treatment (100 μM, 6 h) in presence or absence of ConA (2.5 nM, 2 h).
Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 20;23(12):6860. [Abstract]
Analysis of the autophagic flux in NHF upon treatment with Sildenafil (100 μM, 24 h) in presence or absence of ConA (2.5 nM; 2 h).
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ACS Omega
Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]2020 Nov 15;5(46):29935-29942. PMID: 33251429 -
Biochim Biophys Acta Mol Basis Dis
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes. [Abstract]2024 Mar;1870(3):167018. PMID: 38185350 -
J Nat Med
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor. [Abstract]2025 Sep;79(5):1154-1166. PMID: 40581895 -
Biochem Biophys Res Commun
2021 Apr 2:547:9-14. PMID: 33588236 -
Physiol Rep
β3 adrenergic agonism: A novel pathway which improves right ventricular-pulmonary arterial hemodynamics in pulmonary arterial hypertension. [Abstract]2023 Jan;11(1):e15549. PMID: 36597221
Sildenafil Mesylate purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2023 Jan;11(1):e15549. [Abstract]
The index of cell proliferation in the lungs is significantly reduced in hypoxic mice that received CL316243, Sildenafil (50 mg/kg), or riociguat compared with hypoxic mice treated with vehicle.
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Biomed Chromatogr
A novel standard-free detection of adulteration method for sildenafil derivatives in dietary supplements. [Abstract]2024 Jun 5:e5925. PMID: 38837800
Purity & Documentation
References
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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