1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Tiotropium bromide hydrate

Tiotropium bromide hydrate (Synonyms: BA-679 BR (hydrate))

Cat. No.: HY-B0460
Handling Instructions

Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.

For research use only. We do not sell to patients.

Tiotropium bromide hydrate Chemical Structure

Tiotropium bromide hydrate Chemical Structure

CAS No. : 411207-31-3

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Description

Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Target: mAChR Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2].

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Molecular Weight

490.43

Formula

C₁₉H₂₄BrNO₅S₂

CAS No.

411207-31-3

SMILES

[H][[email protected]@]12[[email protected]@H](O3)[[email protected]@H]3[[email protected]@](C[[email protected]](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2)([H])[N+]1(C)C.O.[Br-]

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tiotropium bromide hydrate
Cat. No.:
HY-B0460
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