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Cat. No.: HY-P992113

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Evabosmig

(Synonyms: AGA2118)

Evabosmig (AGA2118) is a bispecific antibody targeting SOST/sclerostin and DKK-1. Evabosmig binds to both SOST and DKK-1 simultaneously, activates the Wnt/β-catenin signaling pathway, and thereby potently promotes osteogenesis. Evabosmig can be used for the study of osteoporosis.

For research use only. We do not sell to patients.

CAS No.: 3061142-96-6

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Evabosmig Chemical Structure

CAS No.: 3061142-96-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Species Reactivity
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

immunoglobulin (H-gamma4_L-kappa) (H-gamma4_L-kappa)

Species Reactivity

Human

All Wnt Isoforms :

Gene ID

50964 [NCBI] & 22943 [NCBI]

Accession

Q9BQB4 & O94907

Target

SOST/Sclerostin & DKK1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG4-kappa

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 3061142-96-6
SMILES

[Evabosmig]
Synonyms

AGA2118
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Drake, M. T., et al. (2024, September). AGA2118, a bispecific monoclonal antibody neutralizing both sclerostin and DKK1, increased bone Formation, decreased bone resorption, and led to rapid BMD gains in a first in human, single-and multiple-dose, placebo-controlled, randomized study. In ASBMR 2024 Annual Meeting. ASBMR.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Species Reactivity
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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Evabosmig

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Evabosmig Related Classifications

HY-P992113 Related Classifications