USP7-IN-2
USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC50 of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of p21 in multiple cell lines, and can be utilized in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2196243-57-7
- Formula: C29H34N6O3
- Molecular Weight:514.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
>20000 nM
Compound: 27
|
Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant
Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant
|
[PMID: 36306471] |
| MM1.S | IC50 |
585.6 nM
Compound: ALM4
|
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay
|
[PMID: 39133975] |
| REH | IC50 |
20.3 nM
Compound: 4
|
Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
|
[PMID: 39028938] |
| RS4-11 | IC50 |
>20000 nM
Compound: 4
|
Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay
Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay
|
[PMID: 39028938] |
| RS4-11 | IC50 |
69 nM
Compound: 4
|
Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
|
[PMID: 39028938] |
Chemical Information
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CAS No. 2196243-57-7
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Molecular Weight 514.62
-
Formula C29H34N6O3
-
SMILES
O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)