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Cat. No.: HY-17548

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VMY-1-103

VMY-1-103 is an inhibitor for cyclin/Cdk complex, that arrests the cell cycle at G1 phase. VMY-1-103 reduces mitochondrial membrane potential, induces p53 phosphorylation and and PARP cleavage, activates caspase-3, and thus induces apoptosis in prostate cancer cell LNCaP.

For research use only. We do not sell to patients.

CAS No.: 1209002-43-6
Formula: C₃₄H₄₂ClN₉O₄S
Molecular Weight:708.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VMY-1-103 Chemical Structure

CAS No.: 1209002-43-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	10.03 μM Compound: VMY-1-103	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay	[PMID: 21440449]
MCF7	IC₅₀	4.5 μM Compound: VMY-1-103	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by WST-1 assay Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs by WST-1 assay	[PMID: 21440449]
MDA-MB-231	IC₅₀	4.06 μM Compound: VMY-1-103	Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay	[PMID: 21440449]

Chemical Information

CAS No. 1209002-43-6
Molecular Weight 708.27
Formula C₃₄H₄₂ClN₉O₄S
SMILES

O=C(NCCNS(=O)(C1=C2C=CC=C(N(C)C)C2=CC=C1)=O)C3=CC=C(NC4=C5N=CN(C(C)C)C5=NC(N[C@@H](CO)C(C)C)=N4)C=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ringer L, et al., VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer Biol Ther. 2010 Aug 15;10(4):320-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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VMY-1-103

All Caspase Isoforms