WAY 208466

Cat. No.: HY-W794785: Data Sheet Handling Instructions
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WAY 208466 is a selective 5-HT6 receptor agonist with an EC₅₀ of 7.3 nM. WAY-208466 increases GABA levels following both acute and chronic administration in the dorsolateral frontal cortex of rat models with stereotaxic surgery. WAY 208466 can be used for anxiety-related disorders like obsessive compulsive disorder (OCD) research.

For research use only. We do not sell to patients.

WAY 208466 Chemical Structure

CAS No. : 633304-27-5

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of WAY 208466:

WAY208466 dihydrochloride

Other Forms of WAY 208466:

WAY208466 dihydrochloride In-stock

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•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT₆ Receptor

7.3 nM (EC₅₀)

5-HT₇ Receptor

4764 nM (EC₅₀)

5-HT_2A Receptor

351 nM (EC₅₀)

5-HT_2B Receptor

313 nM (EC₅₀)

5-HT_2C (Ant) Rceptor

217 nM (EC₅₀)

5-HT_2C (Ago) Receptor

644 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	351 nM Compound: 10e, WAY-208466	Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	4764 nM Compound: 10e, WAY-208466	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	644 nM Compound: 10e, WAY-208466	Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells	[PMID: 19523834]
CHO-K1	IC₅₀	< 5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	> 5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	> 5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 10e, WAY-208466	Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 20, WAY-208466	Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay	[PMID: 26099069]
HeLa	EC₅₀	7.3 nM Compound: 3b	Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay	[PMID: 19884004]

Molecular Weight

347.41

Formula

C₁₇H₁₈FN₃O₂S

CAS No.

633304-27-5

SMILES

O=S(C1=CC(F)=CC=C1)(C2=CN(CCN(C)C)C3=C2C=CC=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]

WAY 208466 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY 208466633304-27-5WAY208466WAY-2084665-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorAgonist5-HT6 receptorGABADorsolateral frontal cortexSIP rat modelsObsessive compulsive disorderOCDInhibitorinhibitorinhibit

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