WAY 208466
WAY 208466 is a selective 5-HT6 receptor agonist with an EC50 of 7.3 nM. WAY-208466 increases GABA levels following both acute and chronic administration in the dorsolateral frontal cortex of rat models with stereotaxic surgery. WAY 208466 can be used for anxiety-related disorders like obsessive compulsive disorder (OCD) research.
For research use only. We do not sell to patients.
- CAS No.: 633304-27-5
- Formula: C17H18FN3O2S
- Molecular Weight:347.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT6 Receptor 7.3 nM (EC50) |
5-HT7 Receptor 4764 nM (EC50) |
5-HT2A Receptor 351 nM (EC50) |
5-HT2B Receptor 313 nM (EC50) |
5-HT2C (Ant) Rceptor 217 nM (EC50) |
5-HT2C (Ago) Receptor 644 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
351 nM
Compound: 10e, WAY-208466
|
Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells
Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells
|
[PMID: 19523834] |
| CHO | IC50 |
4764 nM
Compound: 10e, WAY-208466
|
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
|
[PMID: 19523834] |
| CHO | IC50 |
644 nM
Compound: 10e, WAY-208466
|
Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells
Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells
|
[PMID: 19523834] |
| CHO-K1 | IC50 |
>5000 nM
Compound: 10e, WAY-208466
|
Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells
Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells
|
[PMID: 19523834] |
| CHO-K1 | IC50 |
<5000 nM
Compound: 10e, WAY-208466
|
Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells
Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells
|
[PMID: 19523834] |
| CHO-K1 | IC50 |
>5000 nM
Compound: 10e, WAY-208466
|
Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells
Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells
|
[PMID: 19523834] |
| HeLa | EC50 |
7.3 nM
Compound: 10e, WAY-208466
|
Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA
Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA
|
[PMID: 19523834] |
| HeLa | EC50 |
7.3 nM
Compound: 3b
|
Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay
Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay
|
[PMID: 19884004] |
| HeLa | EC50 |
7.3 nM
Compound: 20, WAY-208466
|
Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay
Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay
|
[PMID: 26099069] |
Chemical Information
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CAS No. 633304-27-5
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Molecular Weight 347.41
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Formula C17H18FN3O2S
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SMILES
O=S(C1=CC(F)=CC=C1)(C2=CN(CCN(C)C)C3=C2C=CC=N3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)