2. Stem Cell/Wnt
  3. YAP
  4. YAP-TEAD-IN-3

YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50 of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively.

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YAP-TEAD-IN-3 Chemical Structure

YAP-TEAD-IN-3 Chemical Structure

CAS No. : 2714434-21-4

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1 mg USD 420 In-stock
5 mg USD 1050 In-stock
10 mg USD 1700 In-stock
25 mg USD 3400 In-stock
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Based on 1 publication(s) in Google Scholar

YAP-TEAD-IN-3 Related Antibodies

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Description

YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50 of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively[1].

IC50 & Target

IC50: 9 nM (YAP-TEAD)[1]
Molecular Weight

529.96

Formula

C27H26ClF2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C(F)=CC1=C2C[C@](C3=CC=CC=C3)([C@@H]4CCCN4)O1)=[C@]2[C@@]5=C(C(NC)=O)C=NC(OCCO)=C5F
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (235.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8869 mL 9.4347 mL 18.8693 mL
5 mM 0.3774 mL 1.8869 mL 3.7739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8869 mL 9.4347 mL 18.8693 mL 47.1734 mL
5 mM 0.3774 mL 1.8869 mL 3.7739 mL 9.4347 mL
10 mM 0.1887 mL 0.9435 mL 1.8869 mL 4.7173 mL
15 mM 0.1258 mL 0.6290 mL 1.2580 mL 3.1449 mL
20 mM 0.0943 mL 0.4717 mL 0.9435 mL 2.3587 mL
25 mM 0.0755 mL 0.3774 mL 0.7548 mL 1.8869 mL
30 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5724 mL
40 mM 0.0472 mL 0.2359 mL 0.4717 mL 1.1793 mL
50 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9435 mL
60 mM 0.0314 mL 0.1572 mL 0.3145 mL 0.7862 mL
80 mM 0.0236 mL 0.1179 mL 0.2359 mL 0.5897 mL
100 mM 0.0189 mL 0.0943 mL 0.1887 mL 0.4717 mL
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YAP-TEAD-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP-TEAD-IN-32714434-21-4YAPYes-associated proteinInhibitorinhibitorinhibit

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