1. Stem Cell/Wnt
    Apoptosis
  2. Wnt
    Apoptosis
  3. YB-0158

YB-0158 (Synonyms: Wnt pathway inhibitor 2)

Cat. No.: HY-136541 Purity: 99.47%
Handling Instructions

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities.

For research use only. We do not sell to patients.

YB-0158 Chemical Structure

YB-0158 Chemical Structure

CAS No. : 1144043-83-3

Size Price Stock Quantity
5 mg USD 850 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 7600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities[1].

IC50 & Target[1]

Wnt

6.2 μM (IC50)

In Vitro

YB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays[1].
YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YB-0158 displays an EC50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

703.59

Formula

C32H32N7Na2O7P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (142.13 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4213 mL 7.1064 mL 14.2128 mL
5 mM 0.2843 mL 1.4213 mL 2.8426 mL
10 mM 0.1421 mL 0.7106 mL 1.4213 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.55 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
YB-0158
Cat. No.:
HY-136541
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