1. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis ADC Cytotoxin
  3. β-Amanitin

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

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β-Amanitin Chemical Structure

β-Amanitin Chemical Structure

CAS No. : 21150-22-1

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Based on 1 publication(s) in Google Scholar

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Description

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2].
β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 cells
Concentration: 0.01, 0.1, 1, 10, 100 µg/mL
Incubation Time: 36 hours
Result: Showed toxicity in MCF-7 cells.
Molecular Weight

919.95

Formula

C39H53N9O15S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C2=C1)C(C[C@]3([H])NC([C@](NC([C@@]4([H])N(C[C@H](O)C4)C([C@@](CC(O)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC3=O)=O)=O)=O)([H])C5)=O)=O)=O)([H])[C@@H](C)[C@@H](O)CO)=O)=C(N2)S5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥96.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
β-Amanitin
Cat. No.:
HY-125586
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