1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis
    ADC Cytotoxin
  3. β-Amanitin

β-Amanitin 

Cat. No.: HY-125586
Handling Instructions

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

β-Amanitin Chemical Structure

β-Amanitin Chemical Structure

CAS No. : 21150-22-1

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Description

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2].
β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2].

Cell Viability Assay[2]

Cell Line: MCF-7 cells
Concentration: 0.01, 0.1, 1, 10, 100 µg/mL
Incubation Time: 36 hours
Result: Showed toxicity in MCF-7 cells.
Molecular Weight

919.95

Formula

C₃₉H₅₃N₉O₁₅S

CAS No.

21150-22-1

SMILES

OC1=CC=C(C2=C1)C(C[[email protected]]3([H])NC([[email protected]](NC([[email protected]@]4([H])N(C[[email protected]](O)C4)C([[email protected]@](CC(O)=O)([H])NC([[email protected]](NC(CNC([[email protected]@]([[email protected]@H](C)CC)([H])NC(CNC3=O)=O)=O)=O)([H])C5)=O)=O)=O)([H])[[email protected]@H](C)[[email protected]@H](O)CO)=O)=C(N2)S5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

β-AmanitinDNA/RNA SynthesisADC CytotoxincyclicpeptidetoxinpoisonousmushroomcytotoxicproteinsynthesisInhibitorinhibitorinhibit

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β-Amanitin
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