Cefmenoxime hydrochloride
Based on 1 Customer Validation
Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria.
For research use only. We do not sell to patients.
- Purity: 99.29%
- CAS No.: 75738-58-8
- Formula: C16H17.5Cl0.5N9O5S3
- Molecular Weight:529.79
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Antibacterial Compound Library
HY-L049
-
NMPA-Approved Drug Library
HY-L053
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Antibiotics Library
HY-L067
-
Human Metabolite Library
HY-L123
-
Heterocyclic Compound Library
HY-L138
-
Off-patent Drug Library
HY-L141
-
Bioactive Compound Library Max
HY-L181
-
Drug Repurposing Compound Library Plus
HY-L035P
-
FDA-Approved Drug Library Plus
HY-L022P
-
FDA-Approved Drug Library Mini
HY-L022M
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Anti-Infection Compound Library
HY-L002
-
FDA-Approved Drug Library
HY-L022
-
Drug Repurposing Compound Library
HY-L035
All Antibiotic Isoforms
More
Biological Activity
|
β-lactam |
Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1].
Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1].
Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Jcl:ICR mice[2]
-
Dosage:40 mg/kg
-
Administration:Subcutaneous injection; daily, for 7 days
-
Result:Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
Chemical Information
-
CAS No. 75738-58-8
-
Appearance Solid
-
Molecular Weight 529.79
-
Formula C16H17.5Cl0.5N9O5S3
-
Color White to yellow
-
SMILES
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O.[0.5HCl]
-
Synonyms
SCE-1365 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 65 mg/mL (122.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60. [Content Brief]
[2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8875 mL | 9.4377 mL | 18.8754 mL | 47.1885 mL |
| 5 mM | 0.3775 mL | 1.8875 mL | 3.7751 mL | 9.4377 mL | |
| 10 mM | 0.1888 mL | 0.9438 mL | 1.8875 mL | 4.7189 mL | |
| 15 mM | 0.1258 mL | 0.6292 mL | 1.2584 mL | 3.1459 mL | |
| 20 mM | 0.0944 mL | 0.4719 mL | 0.9438 mL | 2.3594 mL | |
| 25 mM | 0.0755 mL | 0.3775 mL | 0.7550 mL | 1.8875 mL | |
| 30 mM | 0.0629 mL | 0.3146 mL | 0.6292 mL | 1.5730 mL | |
| 40 mM | 0.0472 mL | 0.2359 mL | 0.4719 mL | 1.1797 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3775 mL | 0.9438 mL | |
| 60 mM | 0.0315 mL | 0.1573 mL | 0.3146 mL | 0.7865 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2359 mL | 0.5899 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4719 mL |
Cefmenoxime hydrochloride Related Classifications
HY-B0875 Related Classifications
Powered by Bioz