1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Isoquercitrin

Isoquercitrin (Synonyms: Isoquercitroside)

Cat. No.: HY-N0768 Purity: 99.97%
Handling Instructions

Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.

For research use only. We do not sell to patients.

Isoquercitrin Chemical Structure

Isoquercitrin Chemical Structure

CAS No. : 21637-25-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.

In Vitro

Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG[1].

In Vivo

In animals receiving Isoquercitrin, eosinophil counts are lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower only in Isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed[2].

Clinical Trial
Molecular Weight







O=C1C(O[[email protected]@H]2O[[email protected]@]([[email protected]](O)CO)([H])[[email protected]](O)[[email protected]]2O)=C(C3=CC(O)=C(O)C=C3)OC4=CC(O)=CC(O)=C14


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.18 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1534 mL 10.7670 mL 21.5341 mL
5 mM 0.4307 mL 2.1534 mL 4.3068 mL
10 mM 0.2153 mL 1.0767 mL 2.1534 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
Animal Administration

BALB/c mice are immunized (ovalbumin/aluminum hydroxide, s.c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice receive daily gavages of Isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) is administered as a positive control. Leucocytes are analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) is analyzed in BALF and lung homogenates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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IsoquercitrinIsoquercitrosideReactive Oxygen SpeciesInhibitorinhibitorinhibit

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