Infection

Bromfenac (sodium hydrate) (Standard) is the analytical standard of Bromfenac (sodium hydrate). This product is intended for research and analytical applications. Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium hydrate can be used in ocular inflammation research.

Demeclocycline hydrochloride (Standard) is the analytical standard of Demeclocycline hydrochloride (HY-17560). This product is intended for research and analytical applications. Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections.

Flucycloxuron (Andalin) is an insect growth regulator (IGR), and a chitin synthesis inhibitor.

Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase.

Aklaviketone is a bacterial metabolite found in strain S 383 of Streptomyces galilaeus. Aklaviketone can be used in the biosynthetic pathway of anthracycline antibiotics.

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.

10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.

Saquinavir-¹³C₆ (Ro 31-8959-¹³C₆) is ¹³C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.

Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.

Cervicarcin is an antitumor antibiotic with a strong inhibitory effect on sarcoma 180 and sarcoma NF, but has a weak effect on sarcoma 37, Ehrman's ascites cancer and Friend leukemia.

Manumycin F has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin F inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL).

Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii.

MLS8091 is a highly selective inhibitor of the human cytomegalovirus (HCMV) helicase-primase complex with antiviral activity. MLS8091 inhibits HCMV replication during the early and late stages of the virus, and suppresses viral DNA replication as well as all HCMV viral proteins. MLS8091 inhibits guinea pig cytomegalovirus replication, and exerts an additive effect when combined with Letermovir (HY-15233). MLS8091 can be used in studies related to human cytomegalovirus infection.

gp120-IN-3 (Compound 11) is a HIV-1 gp120 inhibitor with an IC₅₀ value of 1.64 nM, which can be utilized in HIV research.

Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi.

Penicillin G procaine (hydrate) (Standard) is the analytical standard of Penicillin G procaine (hydrate). This product is intended for research and analytical applications. Penicillin G Procaine hydrate (PGP hydrate), a β-lactam antibiotic, is a crystalline complex produced by chemically combining penicillin G with procaine.

NBD-10007 is a CD4 agonist. NBD-10007 has anti-HIV-1 viral activity.

(-)-Cedrene (α-cedrene) (Standard) is the analytical standard of (-)-Cedrene. This product is intended for research and analytical applications. (-)-Cedrene is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC₅₀ = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC₅₀ = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity.