Infection

Clindamycin B is a derivative of Clindamycin (HY-B1455).

16-Hydroxyroridin L-2 is a trichothecene group antibiotic. 16-Hydroxyroridin L-2 is a mycotoxin with anti-tumor activity.

Coriolin A has anti-Gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin A of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. Coriolin A has no inhibitory effect on Ehrlich ascites carcinoma in animals.

SARS-CoV-2 Mpro-IN-59 is a competitive, nonpeptidic SARS-CoV-2 M_pro inhibitor. SARS-CoV-2 Mpro-IN-59 can be used for the research of covid-19.

(E)-Methyl 4-coumarate (Standard) is the analytical standard of (E)-Methyl 4-coumarate (HY-N2492). This product is intended for research and analytical applications. (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection.

(S)-ML188 is a SARS-CoV 3-chymotrypsin-like protease (3CLpro) inhibitor (IC₅₀: 1.5 μM). (S)-ML188 has antiviral activity with an EC₅₀ value of 12.9 μM against SARS-CoV. (S)-ML188 inhibits the activity of 3CLpro via non-covalent binding and can be used in the study of SARS-CoV.

TLR7 agonist 1 (Standard) is the analytical standard of TLR7 agonist 1 (HY-111358). This product is intended for research and analytical applications. TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC₅₀ of 90 nM.

Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia.

Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.

Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases.

Prumycin is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca.

CB-618 is a β-lactamase inhibitor. CB-618 reversibly covalently inhibits Ambler class A, C, and some class D serine β-lactamases. CB-618 has weak antibacterial activity as a single agent, but it significantly enhances the antibacterial activity of Meropenem (HY-13678) against enzyme-producing Enterobacteriaceae. CB-618 can be used in research on drug-resistant bacteria.

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

F594-1001 (compound 6) is a potent and highly selective SARS-CoV-2 Mac1-ADP-ribose inhibitor with IC₅₀s of 8.5 μM, 68 μM and 45 μM for SARS-CoV-2 in AS, FP, and FRET assays, respectively. F594-1001 directly binds to SARS-CoV-2 Mac1 and exhibits a dose-dependent inhibition of Mac1 ADP-ribosylhydrolase activity.

N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis.

Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC₅₀ value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide.

Neobulgarone A is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone A can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.

(S,S)-TAPI-0 is a matrix metalloproteinase (MMP) inhibitor that inhibits the growth of Chlamydia trachomatis by inhibiting PDF enzyme activity. (S,S)-TAPI-0 can be used to study Chlamydia infection.

2-Ethyl-6-methylphenol, an alkylphenol, is isolated form the tumorigenic neutral subfraction of cigarette smoke condensate. 2-Ethyl-6-methylphenol exhibits insecticidal and bactericidal activities.

Influenza A virus-IN-17 (Compound 6a) is a potent influenza A inhibitor with EC₉₀s of 3.5 μM and 2.6 μM for H3N2 and H1N1, respectively. Influenza A virus-IN-17 inhibits U2-PB2 chimeric mRNA (EC₉₀ = 2.1 μM from cap snatching polymerase).