Carbonic Anhydrase
Carbonate dehydratase
Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct carbonic anhydrase enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) were described to date. Carbonic anhydrases are involved in numerous physiological and pathological processes. Many of them are important therapeutic targets with the potential to be inhibited to treat a range of disorders including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in many physiological and pathological processes, including respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs; pH and CO2 homeostasis; electrolyte secretion in various tissues and organs; biosynthetic reactions (such as gluconeogenesis, lipogenesis, and ureagenesis); bone resorption; calcification; and tumorigenicity. α-CAs are Zn2+ metalloproteins expressed in animals, vertebrates, prokaryotes, fungi, algae, protozoa, and plants. Sixteen mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc.
Carbonic Anhydrase Isoform Specific Products
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Carbonic Anhydrase
(193)
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CA
(7)
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CA I
(67)
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CA Ⅱ
(119)
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CA IX
(106)
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CA XII
(64)
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CA VII
(1)
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CA VI
(2)
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CA VA
(2)
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CA VB
(2)
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CA XIII
(2)
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CA XIV
(2)
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All Product Categories
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Carbonic Anhydrase Inhibitors
(341)
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Carbonic Anhydrase Activators
(6)
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Carbonic Anhydrase Modulators
(4)
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Carbonic Anhydrase Degrader
(1)
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Carbonic Anhydrase Ligands
(3)
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Carbonic Anhydrase Proteins
(33)
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Carbonic Anhydrase 1 (CA1) Proteins
(1)
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Carbonic Anhydrase 2 (CA-II) Proteins
(3)
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Carbonic Anhydrase 4 (CA IV) Proteins
(3)
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Carbonic Anhydrase 12 (CA-XII) Proteins
(1)
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Carbonic Anhydrase Related Products (381)
Related Products (381)
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Recombinant Proteins (33)
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Carbonic Anhydrase Isoform Comparison
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IPM-N001
0 ImagesCat. No.: HY-P11737IPM-N001 is a carbonic anhydrase IX (CAIX) ligand with a Kd value of <0.0337 nM for hCAIX. When radio-conjugated with 68Ga, IPM-N001 serves as a CAIX-targeted radionuclide tracer. [68Ga]Ga-IPM-N001 exhibits excellent tumor uptake and significantly improves the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 can be used for the research of clear cell renal cell carcinoma.
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AV22-149
0 ImagesCat. No.: HY-169214AV22-149 (compund 22) is an inhibitor of carbonic anhydrase IX.
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hCA/VEGFR-2-IN-4
0 ImagesCat. No.: HY-155763CAS No.: 2971782-83-7hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC50=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.
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CL 5343 (Standard)
0 ImagesCat. No.: HY-W074975RCAS No.: 14949-00-9Synonyms: 5-Amino-1,3,4-thiadiazole-2-sulfonamide (Standard)CL 5343 (Standard) is the analytical standard of CL 5343. This product is intended for research and analytical applications. CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells.
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PDE5/CA-IN-1
0 ImagesCat. No.: HY-181684PDE5/CA-IN-1 is a dual PDE5 and carbonic anhydrase (CA) inhibitor, with IC50 values of 0.41, 38.4, and 9.1 nM against PDE5, hCA II, and hCA VA, respectively. PDE5/CA-IN-1 inhibits multiple hCA subtypes associated with Alzheimer's disease. As a cytoprotective agent and oxidative stress alleviator, PDE5/CA-IN-1 reduces oxidative stress, and prevents recognition memory and working memory impairments. PDE5/CA-IN-1 is available for the research of Alzheimer's disease.
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Carbonic anhydrase inhibitor 12
0 ImagesCat. No.: HY-115999CAS No.: 2883451-38-3Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines.
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hCAIX/XII-IN-3
0 ImagesCat. No.: HY-146258CAS No.: 2414629-94-8hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively.
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hCAII-IN-10
0 ImagesCat. No.: HY-161282hCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC50s of 14 nM and 29.2 μM for hCA II and hCA I, respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC50 of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model.
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BE21349
0 ImagesCat. No.: HY-184660BE21349 is a carbonic anhydrase (CA) inhibitor with Ki values of 2090, 17.1, 61.8, and 40.5 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. BE21349 exhibits submicromolar inhibitory activity against leukemia, non-small cell lung cancer, and melanoma cell lines. BE21349 can be used in cancer-related research such as leukemia, non-small cell lung cancer, and melanoma.
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Carbonic anhydrase inhibitor 24
0 ImagesCat. No.: HY-161686Carbonic anhydrase inhibitor 24 (Compound 11) is a human carbonic anhydrase (carbonic anhydrase) inhibitor. Ki values of Carbonic anhydrase inhibitor 24 for hCAs IX and XII were 10.7 and 7.5 nM, respectively.
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hCAII-IN-4
0 ImagesCat. No.: HY-150973CAS No.: 2816080-18-7hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC50 of 7.78 μM. hCAII-IN-4 also inhibits β-glucuronidase with an IC50 of 773.9 μM.
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hCA/VEGFR-2-IN-2
0 ImagesCat. No.: HY-155758CAS No.: 2971782-66-6hCA/VEGFR-2-IN-2 (compound 8g) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-2 inhibits VEGFR-2 (IC50=204 nM) and has high binding activity to hCAs, with Kis of 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), and 75.3 nM (hCA I), respectively. hCA/VEGFR-2-IN-2 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.
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Carbonic anhydrase inhibitor 9
0 ImagesCat. No.: HY-144807CAS No.: 3033042-50-8Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with Kis of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity.
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hCAXII-IN-5
0 ImagesCat. No.: HY-146256CAS No.: 2414629-92-6hCAXII-IN-5 (compound 6o) is a potent and selective hCAXII inhibitor with Ki values of >10000, >10000, 286.1, 1.0 nM for hCAI, hCAII, hCAIX and hCAXII, respectively.
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CAII-IN-1
0 ImagesCat. No.: HY-151493CAII-IN-1 (compound 3n), a thiosemicarbazide derivative, is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC50 value of 10.3 µM for bovine CA-II. CAII-IN-1 can be used in research of carbonic anhydrase related biological disorders.
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hCAIX-IN-15
0 ImagesCat. No.: HY-151632CAS No.: 2849348-43-0hCAIX-IN-15 is a potent hCA IX inhibitor with a Ki value of 38.8 nM. hCAIX-IN-15 shows good broad-spectrum anticancer activity and can be used for cancer research.
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CAIX/CAXII-IN-2
0 ImagesCat. No.: HY-159132CAS No.: 3067730-65-5CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research.
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CAIX/XII-IN-16
0 ImagesCat. No.: HY-179034CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s Ki values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC50 value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia.
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HDAC-IN-91
0 ImagesCat. No.: HY-175021HDAC-IN-91 is a multiple inhibitor of HDAC (IC50 = 134.22 nM for HDAC1, 66.29 nM for HDAC2), carbonic anhydrase (CA) (Ki = 72.03 nM for CA IX, 50.76 nM for XII), and tubulin polymerization ( IC50 = 2.56 μM). HDAC-IN-91 inhibits PARP1 and increases the Bax/Bcl-2 ratio. HDAC-IN-91 blocks the cell cycle at the G2/M phase and induces apoptosis through a mitochondrial apoptosis activation mechanism. HDAC-IN-91 can exert potent cytotoxic activity through tubulin polymerization inhibition. HDAC-IN-91 can be used in breast, colorectal, cervical and lung cancer research.
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Carbonic anhydrase inhibitor 7
0 ImagesCat. No.: HY-144641CAS No.: 546105-61-7Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively.
