Discoidin Domain Receptor
Discoidin domain receptors (DDRs) are members of the transmembrane receptor tyrosine kinase (RTK) superfamily which are distinguished from others by the presence of a discoidin motif in the extracellular domain and their utilization of collagens as internal ligands. Two types of DDRs, DDR1 and DDR2, have been identified with distinct expression profiles and ligand specificities.
Upon collagen binding, DDRs transduce cellular signaling involved in various cell functions, including cell adhesion, proliferation, differentiation, migration, and matrix homeostasis. Altered DDR function resulting from either mutations or overexpression has been implicated in several types of disease, including atherosclerosis, inflammation, cancer, and tissue fibrosis. DDRs have been considered as novel potential molecular targets for drug discovery and increasing efforts are being devoted to the identification of new small molecule inhibitors targeting the receptors.
Discoidin Domain Receptor Isoform Specific Products
All Product Categories
-
Discoidin Domain Receptor Inhibitors
(45)
View all products
-
Discoidin Domain Receptor Activator
(1)
View all products
-
Discoidin Domain Receptor Modulators
(2)
View all products
-
Discoidin Domain Receptor Degraders
(2)
View all products
-
Discoidin Domain Receptor Ligands
(3)
View all products
-
DDR1/CD167a Proteins
(12)
View all products
-
DDR2 Proteins
(10)
View all products
-
Discoidin Domain Receptor Related Products (58)
Related Products (58)
-
Recombinant Proteins (22)
-
Antibodies (1)
-
Discoidin Domain Receptor Isoform Comparison
-
TPKI-39
0 ImagesCat. No.: HY-181754CAS No.: 1005781-50-9TPKI-39 is a DDR1, DDR2, and FLT1 inhibitor, with a human DDR1 IC50 of 380 nM, human DDR1 Ka of 24 nM, human DDR2 IC50 of 120 nM, human FLT1 IC50 of 65 nM, and human FLT1 Ka of 91 nM.TPKI-39 inhibits DDR1 enzymatic activity and autophosphorylation, DDR2 enzymatic activity, and FLT1 enzymatic activity in cells.TPKI-39 inhibits collagen-induced DDR1 autophosphorylation in cells.
-
Axl-IN-21
0 ImagesCat. No.: HY-179535CAS No.: 1958081-87-2Axl-IN-21 is an orally active and selective AXL inhibitor (Kd = 2.7 nM, IC50 = 4.0 nM). Axl-IN-21 displays kinase selectivity and retains strong activity against cancer-related mul-kinases (Mer with Kd = 1.4 nM, DDR1 with IC50 = 22.2 nM, HIPK4 with Kd = 11.0 nM and LOK with Kd =10 nM). Axl-IN-21 overcomes tumor microenvironment-driven resistance by blocking CAF-derived GAS6-induced AXL/STAT3/ABCG1 signaling, restoring chemosensitivity and inhibiting drug efflux in gastric cancer (GC). Axl-IN-21 suppresses TGF-β1-induced epithelial-mesenchymal transition (EMT), migration, and invasion in MDA-MB-231 cells. Axl-IN-21 exhibits no significant cytotoxicity in non-cancerous cells. Axl-IN-21 can be research for triple negative breast cancer and gastric cancer[1] [2] .
-
Anti-DDR1/CD167a Antibody
0 ImagesCat. No.: HY-P990400Purity: 99.13%Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
-
ML786 dihydrochloride
0 ImagesCat. No.: HY-14979ACAS No.: 1237536-18-3ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.
-
DDR1/2 IN-4
0 ImagesCat. No.: HY-181839CAS No.: 3027967-95-6DDR1/2 IN-4 (Compound 37) is a selective dual DDR1 and DDR2 kinase inhibitor, with a pKi of 8.6 for DDR1 and a pKi of 8.2 for DDR2. DDR1/2 IN-4 functionally inhibits the kinase activities of DDR1 and DDR2. DDR1/2 IN-4 inhibits the release of MCP-1. DDR1/2 IN-4 can be used in studies related to idiopathic pulmonary fibrosis.
-
DDR Inhibitor 2
0 ImagesCat. No.: HY-172797DDR Inhibitor 2 (compound 5a) is a discoidin domain receptor (DDR) inhibitor with an IC50 of 0.125 μM. DDR Inhibitor 2 can be used for study of fibrotic diseases.
-
DDR2-IN-2
0 ImagesCat. No.: HY-176849CAS No.: 3038810-93-1DDR2-IN-2 is a Discoidin domain receptor 2 (DDR2) inhibitor. DDR2-IN-2 can be used for the research of cancer.
-
GW694590A
0 ImagesCat. No.: HY-160689CAS No.: 948313-24-4Synonyms: UNC10112731GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting DDR2, KIT and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene.
-
DDR1-IN-11
0 ImagesCat. No.: HY-173284CAS No.: 639089-54-6DDR1-IN-11 (Compound 4) is an inhibitor of Discoidin domain receptor 1 (DDR1) with an IC50 of 46.16 nM. DDR1-IN-11 can achieve an inhibition rate of 99.86% against Z-138 cells at a concentration of 10 μM, and it can be used in the research of acute myeloid leukemia (AML).
-
ML786
0 ImagesCat. No.: HY-14979CAS No.: 1237586-97-8
-
PRMT/HKMT-IN-1
0 ImagesCat. No.: HY-114510CAS No.: 1020399-52-3PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia.
-
DDR2 N456S Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70693Discoidin domain receptor 2 (DDR2) is a sensor for collagen and by participating in migration, proliferation, and extracellular matrix remodeling. DDR2 N456S is a DDR2 mutation that may be present in non-small cell lung cancer. DDR2 N456S Recombinant Human Active Protein Kinase is a recombinant DDR2 N456S protein that can be used to study DDR2 N456S-related functions.
-
DDR1 ligand 1
0 ImagesCat. No.: HY-176185DDR1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). DDR1 ligand 1 can be used for the synthesis of PROTAC DDR1 degrader-1 (HY-176184).
-
DDR1-IN-8
0 ImagesCat. No.: HY-162102CAS No.: 3038810-92-0DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC50 values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity.
-
DDR1/2 inhibitor-3
0 ImagesCat. No.: HY-122848CAS No.: 2241813-33-0DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 valuesof 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research.
-
O,O-Dimethyl dithiophosphate-13C2 ammonium
0 ImagesCat. No.: HY-W778154CAS No.: 1329610-82-3O,O-Dimethyl dithiophosphate-13C2 ammonium is the 13C labeled isotope of O,O-Dimethyl dithiophosphate ammonium.
