Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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N-Demethyl Mifepristone
0 ImagesCat. No.: HY-W740216CAS No.: 104004-96-8Synonyms: RU 42633N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone.
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5-Methoxy-N-isopropyl tryptamine
0 ImagesCat. No.: HY-W741886CAS No.: 109921-55-35-Methoxy-N-isopropyl tryptamine is a tryptamine. 5-Methoxy-N-isopropyl tryptamine is a metabolite of 5-methoxy DiPT.
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(Rac)-5-Oxo-pitavastatin
0 ImagesCat. No.: HY-180441CAS No.: 1809100-36-4(Rac)-5-Oxo-pitavastatin is a Pitavastatin (HY-B0144A) metabolite.
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Abemaciclib metabolite M2 (Standard)
0 ImagesSynonyms: LSN2839567 (Standard)Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
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Deacetylcephaloglycin
0 ImagesDeacetylcephaloglycin is the active metabolite of Cephaloglycin (HY-16137). Deacetylcephaloglycin is a degradation product of Cephaloglycin that eliminates the 3-acetyl group in acidic medium and can be further degraded to Deacetylcephaloglycin lactone. Deacetylation is the rate-determining step in the degradation of Cephaloglycin to lactone.
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Netupitant metabolite N-desmethyl Netupitant
0 ImagesCat. No.: HY-G0010CAS No.: 290296-72-9Synonyms: N-desmethyl NetupitantN-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
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Desmethylflutiazepam
0 ImagesCat. No.: HY-168354CAS No.: 41191-07-5Synonyms: N-DesmethylfludiazepamDesmethylflutiazepam (N-Desmethylfludiazepam) is a metabolite of various benzodiazepine compounds.
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Desmethylmirtazapine
0 ImagesSynonyms: NormirtazapineDesmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
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Sulfamethoxazole-NO hydrate
0 ImagesCat. No.: HY-163038Synonyms: SMX-NO hydrateSulfamethoxazole-NO (SMX-NO) hydrate is the reactive metabolite of SMX (HY-B0322). Sulfamethoxazole-NO (SMX-NO) hydrate actis as a typical hapten and is capable of covalently modifying the MHC-peptide complex, can stimulate hapten-reactive T cells.
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3β,5α,6β-Trihydroxycholanic acid
0 ImagesCat. No.: HY-169330CAS No.: 16030-92-53β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction.
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2,5-Dimethylbenzoic acid
0 ImagesCat. No.: HY-W017431CAS No.: 610-72-02,5-Dimethylbenzoic acid is one of the main urinary metabolites of Pseudocumene (1,2,4-trimethylbenzene) in rats. 2,5-Dimethylbenzoic acid can be used to quantitatively determine the inhalation exposure level of Pseudocumene.
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Rosuvastatin lactone-d6
0 ImagesCat. No.: HY-138166SRosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
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Deoxycholic acid 3-sulfate disodium
0 ImagesDeoxycholic acid 3-sulfate disodium is a steroid bile salt, a sulfate derivative of the bile acid (BA) deoxycholic acid.
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Etoricoxib N1'-oxide
0 ImagesEtoricoxib N1'-oxide is an Etoricoxib (HY-15321) metabolite. Etoricoxib N1'-oxide does not inhibit COX-1, nor does it significantly inhibit COX-2.
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Myclobutanil hydroxide
0 ImagesCat. No.: HY-W722549CAS No.: 116928-93-9Myclobutanil hydroxide is a triazole fungicide derived from the metabolism of Myclobutanil (HY-B2148).
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Risperidone E-oxime
0 ImagesRisperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
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Fluvoxamine acid
0 ImagesCat. No.: HY-W355652CAS No.: 88699-91-6Fluvoxamino acid is the major metabolite of Fluvoxamine (HY-B0103) produced in the human body, and acts as a 5-HT reuptake transporter inhibitor. Fluvoxamino acid exhibits weaker inhibitory activity against 5-HT reuptake than its parent compound Fluvoxamine, and can synergistically regulate 5-HT transmission with the parent compound. Fluvoxamino acid can be used in the research of major depressive disorder.
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5-Hydroxyomeprazole (Standard)
0 ImagesCat. No.: HY-126857RCAS No.: 92340-57-3Synonyms: Hydroxyomeprazole (Standard)5-Hydroxyomeprazole (Standard) is the analytical standard of 5-Hydroxyomeprazole. This product is intended for research and analytical applications. 5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
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Lurasidone metabolite 14326
0 ImagesCat. No.: HY-G0002CAS No.: 186204-33-1Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone (HY-B0032A) generated via metabolism by CYP3A4. Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone, acting as an antagonist of the dopamine D2 receptor (dopamine D2 receptor), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors (5-HT2A and 5-HT7 receptor), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression.
