2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0626AR
    Potassium sorbate (Standard)
    		Inhibitor
    Potassium sorbate (Standard) is the analytical standard of Potassium sorbate. This product is intended for research and analytical applications. Potassium sorbate (Sorbic acid potassium) is an antibacterial preservative effective against most molds, yeasts, and some bacterial species. Potassium sorbate inhibits microbial growth. Potassium sorbate suppresses the activity of intestinal microorganisms in zebrafish, alters the composition of intestinal flora, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α. Potassium sorbate can be used in research on the prevention and treatment of mold, yeast, and bacterial infections.
    Potassium sorbate (Standard)
  • HY-N3706
    Dehydro-α-lapachone
    		98.77%
    Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L.
    Dehydro-α-lapachone
  • HY-100751
    N-563
    		98.0%
    N-563 is a deoxyspergualin mimetic that stimulates immune responses and enhances resistance to Candida albicans in mice.
    N-563
  • HY-118149A
    (±)9-HpODE
    		Inhibitor 98.9%
    (±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens.
    (±)9-HpODE
  • HY-N10229
    Harzianum A
    		Inhibitor
    Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells.
    Harzianum A
  • HY-N16375
    (3R,6S)-Bassiatin
    		99.9%
    (3R,6S)-Bassiatin (Compound 5) is an enantiomer of the fungal metabolite Bassiatin (HY-165143). Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption.
    (3R,6S)-Bassiatin
  • HY-Y1825R
    Benzimidazole (Standard)
    		Inhibitor
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Benzimidazole (Standard)
  • HY-N0673
    Pseudolaric Acid A
    		Inhibitor 99.90%
    Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.
    Pseudolaric Acid A
  • HY-125969
    Rtt109 inhibitor 1
    		Inhibitor 98.00%
    Rtt109 inhibitor 1 (Compound 1) is an inhibitor for histone acetyltransferase Rtt109 through a tight binding, uncompetitive system. Rtt109 inhibitor 1 exhibits antifungal activity through acetylation at H3K56 site.
    Rtt109 inhibitor 1
  • HY-N7996
    Matairesinoside
    		Inhibitor 99.88%
    Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity.
    Matairesinoside
  • HY-N6635R
    trans-Nerolidol (Standard)
    		Inhibitor
    trans-Nerolidol (Standard) is the analytical standard of trans-Nerolidol. This product is intended for research and analytical applications. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (DOX) (HY-15142A) against intestinal cancer and breast cancer cells in vitro. trans-Nerolidol increases accumulation of DOX inside cells in vitro. trans-Nerolidol activates apoptosis in vivo.
    trans-Nerolidol (Standard)
  • HY-B0139S
    Flucytosine-13C,15N2
    		Inhibitor 98.06%
    Flucytosine-13C,15N2 (NSC 103805-13C,15N2; Ro 2-9915-13C,15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
    Flucytosine-<sup>13</sup>C,15</sup>N<sub>2</sub>
  • HY-N13215
    Tongkat Ali Extract
    		Inhibitor
    Tongkat Ali Extract is the extract of Tongkat Ali, a testosterone modulator. Tongkat Ali Extract activates CYP17 enzyme to enhance conversion of pregnenolone and progesterone to dehydroepiandrosterone, androstenedione, and testosterone. Tongkat Ali Extract demonstrates antimalarial, antimicrobial, anticancer, and antidiabetic activity. Tongkat Ali Extract can be used for the research of diabetic and male infertility.
    Tongkat Ali Extract
  • HY-N8052
    (-)-Antofine
    		Inhibitor 99.40%
    (-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound.
    (-)-Antofine
  • HY-P4809
    Polybia-MP1
    		Inhibitor 99.03%
    Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers.
    Polybia-MP1
  • HY-A0278R
    Hexaconazole (Standard)
    		Inhibitor
    Hexaconazole (Standard) is the analytical standard of Hexaconazole. This product is intended for research and analytical applications.
    Hexaconazole (Standard)
  • HY-W012349
    2′-Hydroxychalcone
    		Inhibitor
    2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.
    2′-Hydroxychalcone
  • HY-121628
    Flusulfamide
    		Inhibitor
    Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control.
    Flusulfamide
  • HY-W516735
    Sedaxane
    		Inhibitor 98.49%
    Sedaxane is a new broad-spectrum seed treatment fungicide. Sedaxane inhibits fungal respiration by binding to the succinate dehydrogenase complex in fungal mitochondria. Sedaxane has broad-spectrum activity against a variety of seed-borne and soil-borne fungi. Sedaxane can be used in the study of barley loose smut and barley stripe disease.
    Sedaxane
  • HY-B2012R
    Flusilazole (Standard)
    		Inhibitor
    Flusilazole (Standard) is the analytical standard of Flusilazole. This product is intended for research and analytical applications. Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture.
    Flusilazole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity