2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin
  5. Kinesin-5/Eg5/KSP Isoform
  6. Kinesin-5/Eg5/KSP Inhibitor

Kinesin-5/Eg5/KSP Inhibitor

Kinesin-5/Eg5/KSP Inhibitors (13):

Cat. No. Product Name Effect Purity
  • HY-50759
    Ispinesib
    		Inhibitor 99.62%
    Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
  • HY-15187
    Filanesib
    		Inhibitor 98.23%
    Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.
  • HY-101071A
    Monastrol
    		Inhibitor 99.70%
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
  • HY-12069
    SB-743921 hydrochloride
    		Inhibitor 99.87%
    SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
  • HY-14846
    Litronesib
    		Inhibitor 99.59%
    Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
  • HY-W011102
    S-Trityl-L-cysteine
    		Inhibitor 98.99%
    S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities.
  • HY-15000
    EMD534085
    		Inhibitor 99.55%
    EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
  • HY-19944
    Dimethylenastron
    		Inhibitor 98.68%
    Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM.
  • HY-19966
    K858 (Racemic)
    		Inhibitor 99.83%
    K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
  • HY-16062
    ARQ 621
    		Inhibitor ≥99.0%
    ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity. ARQ 621 is a kinesin inhibitor. ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-122247
    PVZB1194
    		Inhibitor 99.90%
    PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein Eg5 or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity.
  • HY-50672
    MK-0731
    		Inhibitor
    MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy.
  • HY-112915
    Eg5 Inhibitor V, trans-24
    		Inhibitor
    Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.