Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
All Product Categories
-
Ligands for Target Protein for PROTAC Inhibitors
(3)
View all products
-
Ligands for Target Protein for PROTAC Chemicals
(6)
View all products
-
Ligands for Target Protein for PROTAC Degrader
(1)
View all products
-
Ligands for Target Protein for PROTAC Controls
(9)
View all products
-
Ligands for Target Protein for PROTAC Ligands
(12)
View all products
-
Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
-
Related Compound Screening Libraries (1)
-
PIN1 ligand-2
0 ImagesCat. No.: HY-171442CAS No.: 2957895-02-0
-
ER ligand-5
0 ImagesCat. No.: HY-170339CAS No.: 2421262-07-7ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336).
-
Imatinib carbaldehyde
0 ImagesCat. No.: HY-111849CAS No.: 1436868-85-7Synonyms: CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
-
TYK2 ligand 3
0 ImagesCat. No.: HY-401428CAS No.: 2921556-43-4TYK2 ligand 3 is a TYK2 ligand that can be used for the synthesis of PROTACs, such as PROTAC TYK2 degrader-2 (HY-152227).
-
ATR ligand 2
0 ImagesCat. No.: HY-182017CAS No.: 3060178-60-8ATR ligand 2 (Compound 26) is a ATR PROTAC ligand. ATR ligand 2 can be conjugated with E3 ligase Ligand (HY-W077589A) and linker to synthesize PROTAC ATR degrader-3 (HY-182016).
-
BCL-xL ligand 4
0 ImagesCat. No.: HY-184547CAS No.: 3027548-08-6BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B).
