Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
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Ligands for Target Protein for PROTAC Chemicals
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Ligands for Target Protein for PROTAC Degrader
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Ligands for Target Protein for PROTAC Controls
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Ligands for Target Protein for PROTAC Ligands
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Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
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Related Compound Screening Libraries (1)
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TEAD ligand 5
0 ImagesCat. No.: HY-181595CAS No.: 2417720-74-0TEAD ligand 5 (Compound S19) is a TEAD PROTAC ligand. TEAD ligand 5 can be conjugated with E3 ligase Ligand (HY-181531) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .
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RSL3-4-Me
0 ImagesCat. No.: HY-169375CAS No.: 3049087-33-1RSL3-4-Me is the active control of the target protein ligand Demethyl-RSL3 (HY-135832), which can be used for the synthesis of PROTAC .
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M4K2163
0 ImagesCat. No.: HY-183720CAS No.: 2600795-21-7M4K2163 is a ALK2 inhibitor that serves as a target protein ligand for the synthesis of PROTACs, such as M4K3250 (HY-183718). M4K2163 induces cytotoxic effects in glioblastoma cells. M4K2163 can be used in the research of diffuse intrinsic pontine glioma and glioblastoma.
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PTPN2 ligand 1
0 ImagesCat. No.: HY-168691CAS No.: 3032975-34-8PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760).
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CDK9 ligand 1
0 ImagesCat. No.: HY-150889CAS No.: 2118356-94-6CDK9 ligand 1 is a CDK9-targeting ligand. CDK9 ligand 1 can be used for PROTAC synthesis, and serves as the target protein ligand for PROTAC CDK9 Degrader-1 (HY-103628).
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RU 56187
0 ImagesCat. No.: HY-117486CAS No.: 143782-25-6RU 56187 is an active compound.
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PDEδ-IN-1
0 ImagesCat. No.: HY-175689CAS No.: 903157-37-9PDEδ-IN-1 is the ligand of PDEδ. PDEδ-IN-1 can be used to synthesize PDEδ autophagic degrader 1 (HY-157458).
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ALK5 ligand-1
0 ImagesCat. No.: HY-183441CAS No.: 3125240-66-3ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.
