Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
(3)
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
(9)
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Ligands for Target Protein for PROTAC Ligands
(12)
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Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
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Related Compound Screening Libraries (1)
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PIP4K ligand-1
0 ImagesCat. No.: HY-189438PIP4K ligand-1 is the target protein ligand for the molecular glue LRK-4189 (HY-175751) and can be used in research on microsatellite-stable colorectal cancer.
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HSP90-IN-35
0 ImagesCat. No.: HY-170326CAS No.: 1207597-54-3Hsp90-in-35 is an inhibitor of Hsp90, with an IC50 between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize KRAS G12C degrader-1 (PROTAC) (HY-153881).
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GNF5-amido-Me
0 ImagesCat. No.: HY-111852CAS No.: 778277-37-5Synonyms: PROTAC ABL binding moiety 2GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
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BRD4 ligand 17
0 ImagesCat. No.: HY-116356CAS No.: 1629730-92-2
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KRAS G12D ligand-2
0 ImagesCat. No.: HY-168700KRAS G12D ligand-2 is a Ligand for Target Protein for PROTAC. KRAS G12D ligand-2 can be used to synthesize Setidegrasib (HY-148273).
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SOS1 Ligand intermediate-4
0 ImagesCat. No.: HY-161635CAS No.: 3036155-94-6SOS1 Ligand intermediate-4 is a ligand of SOS1, used for the synthesis of PROTAC SOS1 degrader (HY-161634).
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Mivebresib-alkyne
0 ImagesCat. No.: HY-169980CAS No.: 2409674-37-7Mivebresib-alkyne (Compound 25), a Mivebresib (HY-100015) derivative, can be used for BRD4 targeted PROTAC synthesis through click reaction.
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ER ligand-7
0 ImagesCat. No.: HY-170334ER ligand-7 is the ligand for estrogen receptor, and can be used for synthesis of PROTAC ER Degrader-15 (HY-170332) as ligand for target protein.
