Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
(3)
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
(9)
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Ligands for Target Protein for PROTAC Ligands
(12)
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Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
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Related Compound Screening Libraries (1)
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BRD3 ligand-1
0 ImagesCat. No.: HY-180901CAS No.: 2257497-24-6BRD3 ligand-1 is a BRD3 ligand that can be used in studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC BRD3 degrader-1 (HY-180889).
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ER ligand-6
0 ImagesCat. No.: HY-170341CAS No.: 2504914-79-6
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CYP1B1 ligand 2
0 ImagesCat. No.: HY-158430CAS No.: 2836297-58-4CYP1B1 ligand 2 is a target protein ligand of PROTAC CYP1B1 degrader-2 (HY-158429). CYP1B1 ligand 2 can be used to study lung cancer.
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AP-24567
0 ImagesCat. No.: HY-125142CAS No.: 943319-87-7AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342).
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AR ligand-33
0 ImagesCat. No.: HY-170330AR ligand-33 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-8 (HY-170329) as the target protein ligand.
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AR ligand-38
0 ImagesCat. No.: HY-170450AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448).
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HDAC-IN-97
0 ImagesCat. No.: HY-177776CAS No.: 149647-86-9
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BRD9 ligand-5
0 ImagesCat. No.: HY-169988CAS No.: 2633634-64-5
