Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
All Product Categories
-
Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
-
7-Methylguanosine-d3
0 ImagesCat. No.: HY-122524SPurity: 98.54%7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM.
-
2'-O,4'-C-Methyleneguanosine
0 ImagesSynonyms: LNA-G2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products.
-
1,N6-Ethenoadenosine
0 Images1,N6-Ethenoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3'-O-Methylguanosine
0 Images3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
-
2′-Deoxy-2′-fluoroguanosine
0 Images2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent influenza virus inhibitor with an EC90 value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation.
-
5'-O-DMT-Bz-rA
0 Images5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis.
-
5-Fluorouracil-d1
0 ImagesSynonyms: 5-FU-d15-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
-
5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
0 ImagesCat. No.: HY-W025438CAS No.: 103285-22-95’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a 2'-O-methyluridine derivative bearing a 5'-O-(4,4'-dimethoxytrityl) protecting group.5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine serves as a starting material for synthesis of a conformationally rigid cyclic uridylic acid derivative.
-
SIBA
0 ImagesSynonyms: 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosineSIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies.
-
Gemcitabine hydrochloride (Standard)
0 ImagesSynonyms: LY 188011 hydrochloride (Standard)Gemcitabine (hydrochloride) (Standard) is the analytical standard of Gemcitabine (hydrochloride). This product is intended for research and analytical applications. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
-
5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
0 Images5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
-
5'-O-DMT-Bz-rC
0 Images5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
-
Uridine-13C9, 15N2
0 ImagesSynonyms: β-Uridine-13C9,15N2
-
N-Propargyladenosine
0 ImagesN-Propargyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). N-Propargyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
dGTP-13C10,15N5 dilithium
0 ImagesCat. No.: HY-138616S4Purity: 98.2%Synonyms: 2'-Deoxyguanosine-5'-triphosphate-13C10,15N5 dilithiumdGTP-13C10,15N5 (2'-Deoxyguanosine-5'-triphosphate-13C10,15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
-
DMT-dC(ac) Phosphoramidite
0 ImagesDMT-dC (ac) Phosphoramidite is a phosphoramidite used for incorporating N4-acetyl deoxycytidine into oligonucleotides. DMT-dC (ac) Phosphoramidite enables the synthesis of modified DNA sequences via standard solid-phase chemistry. DMT-dC (ac) Phosphoramidite is used in research on oligonucleotide synthesis.
-
8-Bromoadenosine
0 Images8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
-
Peldesine dihydrochloride
0 ImagesSynonyms: BCX 34 dihydrochloridePeldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
