P2X Receptor
P2XRs
P2X receptors are a family of seven (P2X1R-P2X7R) cation permeable ligand-gated ion channels (LGICs) that open in response to binding by the extracellular ligand, adenosine 5′-triphosphate (ATP). P2X receptors have a high permeability to Ca2+, Na+, and K+ and are expressed widely throughout the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems.
P2X receptors are widely expressed in excitatory and non-excitatory cells, such as neuron, glia, platelet, epithelia and macrophage, and participate in many important physiological and pathological processes, including synaptic transmission, pain perception, inflammation, cardiovascular modulation, immunomodulation and tumorigenesis.
P2X Receptor Isoform Specific Products
All Product Categories
-
P2X Receptor Related Products (159)
Related Products (159)
-
P2X Receptor Isoform Comparison
-
Blue FPG-A trisodium
0 ImagesCat. No.: HY-D1199CAS No.: 78617-94-4Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2).
-
AF-353 hydrochloride
0 ImagesCat. No.: HY-14483ACAS No.: 927887-18-1Synonyms: Ro-4 hydrochlorideAF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3.
-
P2X3 antagonist 38
0 ImagesCat. No.: HY-153710CAS No.: 2545974-71-6P2X3 antagonist 38 (compound 4) is a potent and orally active P2X3 antagonist with IC50 values of 0.132, 0.165, 0.421 µM for hP2X3, rP2X3, gpP2X3, respectively.
-
P2X4 antagonist-3
0 ImagesCat. No.: HY-170804P2X4 antagonist-3 (Compound 14c) is a P2X4 antagonist with an IC50 value of 1.2 μM. P2X4 antagonist-3 is promising for research of neuroinflammation, chronic pain, and cancer progression.
-
P2X4 antagonist-4
0 ImagesCat. No.: HY-168474CAS No.: 3108486-39-8P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. P2X4 antagonist-4 blocks the ATP-induced NLRP3 inflammasome activation and release of IL-1β.
-
Purotoxin 1
0 ImagesCat. No.: HY-P1330CAS No.: 1396322-38-5Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp.
-
Minodronic acid-d4
0 ImagesCat. No.: HY-16322SCAS No.: 1807367-80-1Synonyms: YM-529-d4Minodronic acid-d4 (YM-529-d4) is deuterium labeled Minodronic acid (HY-16322). Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC50 of 3 nM, and also an antagonist of P2X2/3 receptors with an IC50 of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer.
-
Diadenosine pentaphosphate
0 ImagesCat. No.: HY-113273CAS No.: 41708-91-2Synonyms: Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphateDiadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain).
-
(S)-JNJ-54166060
0 ImagesCat. No.: HY-124300ACAS No.: 1627900-42-8(S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist.
-
NF864
0 ImagesCat. No.: HY-130284CAS No.: 69606-09-3NF864 is a selectivelyP2X1 receptorinhibitor in human platelets.
-
MRS4596
0 ImagesCat. No.: HY-151546CAS No.: 2840581-38-4MRS4596 is a potent and selective P2X4 receptor antagonist with an IC50 value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .
-
Iso-PPADS tetrasodium
0 ImagesCat. No.: HY-101077CAS No.: 207572-67-6Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI).
-
EVT-401
0 ImagesCat. No.: HY-178230CAS No.: 951015-69-3EVT-401 is an orally active, potent and highly selective human P2X7R antagonist, with an IC50 of 10 nM and a Ki of 7.6 nM for human P2X7R, and an IC50 of 220 nM for mouse P2X7R. EVT-401 promotes apoptosis and induces cell cycle arrest in human rheumatoid arthritis synovial fibroblasts (RA SF), reduces the production of proinflammatory and joint-destructive mediators, and mitigates aggressive phenotypes. EVT-401 exhibits favorable oral bioavailability and a good safety profile, making it suitable for research into rheumatoid arthritis.
-
TNP-ATP tetrasodium
0 ImagesCat. No.: HY-137610ATNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg)[1][2].
-
MSK-9
0 ImagesCat. No.: HY-176731MSK-9 is a positive allosteric modulator of the P2X4 receptor with dual activities of enhancing ion conductance and delaying receptor inactivation. MSK-9 stabilizes the open state of the P2X4 receptor through rigid 3-piperidinyl and hydrophobic menthyl substituents. MSK-9 can be used in the study of multiple sclerosis (MS).
-
Femopixant
0 ImagesCat. No.: HY-137136CAS No.: 2310392-52-8Femopixant is a P2X3 and P2X2/3 receptor antagonist. Femopixant can be used for the research of pain.
-
JNJ-54166060
0 ImagesCat. No.: HY-124300CAS No.: 1627900-41-7JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.
-
P2X4 antagonist-2
0 ImagesCat. No.: HY-160677CAS No.: 2055601-24-4P2X4 antagonist-2 is an antagonist for P2X4 with an IC50 of 24 nM.
-
P2X7R antagonist-1
0 ImagesCat. No.: HY-183784P2X7R antagonist-1 is an orally active P2X7 receptor antagonist with an IC50 of 3.57 μM. P2X7R antagonist-1 inhibits the proliferation, invasion and metastasis abilities of cancer cells. P2X7R antagonist-1 downregulates the expression of FAK and MMP-9. P2X7R antagonist-1 suppresses tumor growth and metastasis in a mouse breast cancer model. P2X7R antagonist-1 promotes the activation of CD4 and CD8 T cells. P2X7R antagonist-1 can be used in breast cancer-related research.
