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  4. PKC

PKC

Protein kinase C

PKC

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Nombre del producto Efecto Pureza Chemical Structure
  • HY-P10256
    Kiss2 peptide
    		Activator
    Kiss2 peptide is a positive regulator of reproduction. Kiss2 peptide binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).
    Kiss2 peptide
  • HY-131220
    aPKC-IN-1
    		Inhibitor
    aPKC-IN-1 (compound 1) is an atypical protein kinase C (aPKCζ) inhibitor. aPKC-IN-1 can be used for the study of a host of diseases involving increased vascular permeability and inflammation.
    aPKC-IN-1
  • HY-12663
    AS2521780
    		Inhibitor
    AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.
    AS2521780
  • HY-P1391A
    ZIP(Scrambled) TFA
    		Control
    ZIP(Scrambled) TFA is a scrambled control peptide for zeta inhibitory peptide (ZIP).
    ZIP(Scrambled) TFA
  • HY-175401
    ICP-103
    		Inhibitor
    ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC50 of 30 nM. ICP-103 is promising for research of cancers.
    ICP-103
  • HY-P5888
    PKCε inhibitor peptide,myristoylated
    		Inhibitor
    PKCε inhibitor peptide,myristoylated (Myr-PKCε-) is a cell permeable myristic acid conjugated PKC peptide inhibitor that attenuates NO release in cultured human umbilical vein endothelial cells (HUVECs).
    PKCε inhibitor peptide,myristoylated
  • HY-144307
    Aurora A/PKC-IN-1
    		Inhibitor
    Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity.
    Aurora A/PKC-IN-1
  • HY-112477A
    (E/Z)-Chk2-IN-1
    		Inhibitor
    (E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer.
    (E/Z)-Chk2-IN-1
  • HY-100984A
    HA-100 hydrochloride
    		Inhibitor
    HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor.
    HA-100 hydrochloride
  • HY-RS11145
    Prkd1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkd1 Mouse Pre-designed siRNA Set A
  • HY-148413A
    Aprinocarsen sodium scrambled negative control
    		Inhibitor
    Aprinocarsen sodium scrambled negative control is the sequence scrambled negative control of Aprinocarsen sodium.
    Aprinocarsen sodium scrambled negative control
  • HY-180197
    PICK1 PDZ-IN-1
    		Inhibitor
    PICK1 PDZ-IN-1 (Compound 6b) is a selective and brain-penetrant protein interacting with C kinase 1 (PICK1) PDZ domain inhibitor with a Ki of 27.73 μM. PICK1 PDZ-IN-1 can competitively inhibit the interaction between PICK1 and the GluA2 subunit of AMPA receptors. PICK1 PDZ-IN-1 can increase the survival rate of HT22 cells and primary cortical neuron cells induced by glutamate and inhibit ROS production. PICK1 PDZ-IN-1 exhibits neuroprotective effect and reduces the area of cerebral infarction. PICK1 PDZ-IN-1 can be used for the research of ischemic stroke.
    PICK1 PDZ-IN-1
  • HY-P1054
    pep2-EVKI
    		Inhibitor
    pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression.
    pep2-EVKI
  • HY-N7144AR
    Citronellyl acetate (Standard)
    Citronellyl acetate (Standard) is the analytical standard of Citronellyl acetate (HY-N7144A). This product is intended for research and analytical applications. Citronellyl acetate is a monoterpene product of the secondary metabolism of plants, with antinociceptive activity. Citronellyl acetate exhibits pro-apoptotic activity in human hepatoma cells. Citronellyl acetate shows fungicidal, larvicidal, bactericidal and repelling/insecticidal effects.
    Citronellyl acetate (Standard)
  • HY-139466
    PF-03622905
    		Inhibitor
    PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases.
    PF-03622905
  • HY-E70108
    Cytidylate kinase
    Cytidylate kinase catalyzes the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates.
    Cytidylate kinase
  • HY-P3940
    Ac-MBP (4-14) Peptide
    Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases.
    Ac-MBP (4-14) Peptide
  • HY-P1372
    PKC ζ pseudosubstrate
    		Inhibitor
    PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide.
    PKC ζ pseudosubstrate
  • HY-E70853
    PKCδ Recombinant Human Active Protein Kinase
    PKCδ is a PKC isoform. PKCδ is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. PKCδ Recombinant Human Active Protein Kinase is a recombinant PKCδ protein that can be used to study PKCδ-related functions.
    PKCδ Recombinant Human Active Protein Kinase
  • HY-N1400R
    (20R)-Ginsenoside Rh1 (Standard)
    (20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1 (HY-N1400). This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects.
    (20R)-Ginsenoside Rh1 (Standard)
Cat. No. Nombre del producto / Synonyms Application Reactivity
PKC Isoform Comparison

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