PROTACs
PROTAC (PROteolysis-TArgeting Chimera) is a heterobifunctional nanomolecule containing two different ligands, ligand for ubiquitin E3 and ligand for target protein. The two parts are connected by linker to form a "three-unit" polymer, target protein ligand-linker-E3 ligase ligand. Building blocks of PROTAC molecules include PROTAC Linker, Ligand for Target Protein for PROTAC, Ligand for E3 Ligase, E3 Ligase Ligand-Linker Conjugate, Target Protein Ligand-Linker Conjugate, etc.
PROTACs Isoform Specific Products
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PROTACs Related Products (1390)
Related Products (1390)
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Antibodies (1)
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PROTACs Isoform Comparison
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ZBP1 PROTAC-1
0 ImagesCat. No.: HY-185102ZBP1 PROTAC-1 is a PROTAC degrader targeting ZBP1, with a DC50 of 81.52 nM. ZBP1 PROTAC-1 uses a DNA aptamer to specifically bind ZBP1, recruits the VHL E3 ubiquitin ligase, and induces ZBP1 degradation via the ubiquitin-proteasome pathway. ZBP1 PROTAC-1 can partially restore the viability of H1N1-infected cells. ZBP1 PROTAC-1 can be used in studies related to viral pneumonia and influenza A H1N1 virus infection.
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AU-15330 (Standard)
0 ImagesCat. No.: HY-145388RCAS No.: 2380274-50-8AU-15330 (Standard) is the analytical standard of AU-15330 (HY-145388). This product is intended for research and analytical applications. AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity.
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dTAGV-1 TFA (Standard)
0 ImagesCat. No.: HY-145514RCAS No.: 2624313-15-9dTAGV-1 TFA (Standard) is the analytical standard of dTAGV-1 TFA (HY-145514). This product is intended for research and analytical applications. dTAGV-1 TFA is a selective FKBP12F36V PORTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins.
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PROTAC ERα Degrader-2 (Standard)
0 ImagesCat. No.: HY-111846RCAS No.: 1351169-29-3PROTAC ERα Degrader-2 (Standard) is the analytical standard of PROTAC ERα Degrader-2 (HY-111846). This product is intended for research and analytical applications. PROTAC ERα Degrader-2 (Compound 11) is a ERα PROTAC degrader. PROTAC ERα Degrader-2 significantly down-regulates the level of ERα in MCF-7 cells.(Pink: AR ligand (HY-43962), Blue: IAP Ligand (HY-177389), Black: Linker (HY-128833)).
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SNIPER(BRD)-1 (Standard)
0 ImagesCat. No.: HY-111875RCAS No.: 2095244-54-3SNIPER(BRD)-1 (Standard) is the analytical standard of SNIPER(BRD)-1 (HY-111875). This product is intended for research and analytical applications. SNIPER(BRD)-1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER(BRD)-1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research. (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))
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FKBP12 PROTAC dTAG-13 (Standard)
0 ImagesCat. No.: HY-114421RCAS No.: 2064175-41-1Synonyms: dTAG-13 (Standard)FKBP12 PROTAC dTAG-13 (Standard) is the analytical standard of FKBP12 PROTAC dTAG-13 (HY-114421). This product is intended for research and analytical applications. FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12F36V, without degrading wild-type FKBP12 or un-fused PXR. It weakly promotes the recruitment of SRC-1, strongly inhibits the interaction between NCoR and PXR, and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia.
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dTAG-Fluorescein
0 ImagesCat. No.: HY-183439CAS No.: 2365116-48-7dTAG-Fluorescein is a dTAG-class PROTAC conjugated with fluorescein. dTAG-Fluorescein is applicable to homogeneous time-resolved fluorescence (HTRF) competitive displacement binding assays to detect binding affinity with His-FKBP12F36V. dTAG-Fluorescein can recruit VHL or CRBN E3 ligase complexes, thereby specifically driving the selective degradation of FKBP12F36V-tagged proteins, with very limited activity against FKBP12WT and IKZF1.
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PROTAC BRD4 Degrader-49
0 ImagesCat. No.: HY-185854CAS No.: 3115940-40-1BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer.
