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Art. -Nr.: HY-186272

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MS8847N2

MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation.

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CAS. Nr.: 3050872-64-2
Formel: C₇₀H₉₈N₁₀O₈S
Molecular Weight:1239.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MS8847N2 Chemical Structure

CAS. Nr.: 3050872-64-2

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation^[1].

In Vitro

MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 or reduce H3K27me3 levels in EOL-1 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM^[1].
MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 in MV4;11 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM, with only minimal reduction of H3K27me3 levels^[1].
MS8847N2 (5 days) does not inhibit cell growth in MV4;11 MLL-rearranged acute myeloid leukemia cells after 5 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

EOL-1 MLL-rearranged acute myeloid leukemia cells
Concentration:

0.03, 0.1, 0.3 μM
Incubation Time:

24 h
Result:

Showed no degradation of EZH2 protein at any tested concentration.
Showed no reduction of H3K27me3 protein levels compared to DMSO control.

Western Blot Analysis^[1]

Cell Line:

MV4;11 MLL-rearranged acute myeloid leukemia cells
Concentration:

0.03, 0.1, 0.3 μM
Incubation Time:

24 h
Result:

Showed no degradation of EZH2 protein at any tested concentration.
Showed only minimal reduction of H3K27me3 protein levels compared to DMSO control.

Chemical Information

CAS. Nr. 3050872-64-2
Molecular Weight 1239.65
Formel C₇₀H₉₈N₁₀O₈S
SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)CCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Velez J, et al. Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2. European journal of medicinal chemistry. 2024 Mar 05;267:116154. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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