Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
(553)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(198)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
(915)
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Phosphodiesterase (PDE) Agonists
(3)
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
(8)
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Phosphodiesterase (PDE) Degraders
(4)
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
(1)
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Phosphodiesterase (PDE) Related Products (1009)
Related Products (1009)
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Antibodies (4)
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Phosphodiesterase (PDE) Isoform Comparison
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Vardenafil (Standard)
0 ImagesVardenafil (Standard) is the analytical standard of Vardenafil. This product is intended for research and analytical applications. Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
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Saterinone hydrochloride
0 ImagesCat. No.: HY-101644ACAS No.: 102685-83-6Synonyms: BDF 8634 hydrochlorideSaterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor.
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WAY127093B racemate
0 ImagesCat. No.: HY-101749CAS No.: 145743-63-1WAY127093B racemate is the racemate of WAY127093B. WAY127093B is an orally active phosphodiesterase IV inhibitor in guinea pigs and rats.
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Ro-15-2041
0 ImagesCat. No.: HY-101807CAS No.: 77448-87-4Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties.
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Win 58237
0 ImagesCat. No.: HY-101661CAS No.: 158001-76-4Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with Ki of 170 nM for PDE V, possessing vasorelaxant activity.
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LAS-31180
0 ImagesCat. No.: HY-101811CAS No.: 137338-43-3LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
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ER21355
0 ImagesCat. No.: HY-101826CAS No.: 150452-18-9ER21355 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
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Cirsimarin (Standard)
0 ImagesCat. No.: HY-N7272RCAS No.: 13020-19-4Cirsimarin (Standard) is the analytical standard of Cirsimarin. This product is intended for research and analytical applications. Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase.
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TAK-915 (Standard)
0 ImagesCat. No.: HY-103493RCAS No.: 1476727-50-0TAK-915 (Standard) is the analytical standard of TAK-915 (HY-103493). This product is intended for research and analytical applications. TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment.
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PF-06815189
0 ImagesCat. No.: HY-124173CAS No.: 2218484-75-2PF-06815189 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.4 nM.
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Mardepodect precursor
0 ImagesCat. No.: HY-169773CAS No.: 871507-11-8Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs.
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Balipodect (Standard)
0 ImagesSynonyms: TAK-063 (Standard)Balipodect (Standard) is the analytical standard of Balipodect. This product is intended for research and analytical applications. Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
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CI-1018
0 ImagesCat. No.: HY-19299CAS No.: 245329-99-1CI-1018 is an orally active selective PDE-4 inhibitor, with IC50 values of 1.1 μM, 35.8 μM, and 73.4 μM against hPDE-4, canine PDE-4, and guinea pig PDE-4, respectively. CI-1018 induces iNOS expression and Apoptosis. CI-1018 induces vascular injury, medial necrosis, hemorrhage, edema, thymic atrophy, ketonuria, and weight loss. CI-1018 can be used in research related to asthma, vasculitis, and mesenteric vasculitis/arteriopathy.
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Dipyridamole (Standard)
0 ImagesDipyridamole (Standard) is the analytical standard of Dipyridamole. This product is intended for research and analytical applications. Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.
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LY 186126
0 ImagesCat. No.: HY-109992CAS No.: 100644-00-6LY 186126 a Indolidan analog, is a phosphodiesterase (PDE) inhibitor. LY 186126 binds to cardiac sarcoplasmic reticulum PDE with high affinity, with a Kd of 5.6 nM.
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KF-17625
0 ImagesCat. No.: HY-105505CAS No.: 139339-02-9KF-17625 is an orally active bronchodilator. KF-17625 can inhibit bronchoconstriction induced by Carbachol (HY-B1208), Histamine (HY-B1204), or Leukotriene D4 (HY-113456). KF-17625 can inhibit canine tracheal phosphodiesterase (PDE) IV (IC50 = 12 μM) and Concanavalin-A (HY-P2149)-induced histamine release from rat mast cells (44% inhibition at 10 mM). KF-17625 can be used for the researches of immunology and inflammation.
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NSC-88915
0 ImagesCat. No.: HY-124486CAS No.: 21170-34-3NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative.
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Quazodine
0 ImagesQuazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research.
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Sildenafil-d5
0 ImagesCat. No.: HY-15025S3CAS No.: 951385-70-9Synonyms: UK-92480-d5Sildenafil-d5 (UK-92480-d5) is deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
