Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Activators
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (767)
Related Products (767)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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Pimilprost
0 ImagesCat. No.: HY-106893CAS No.: 139403-31-9Synonyms: SM 10902Pimilprost (SM 10902) is a prostaglandin I1 analogue. Pimilprost exhibits antithrombotic and increases cAMP levels. Pimilprost can promote wound healing through the stimulation of angiogenesis and the improvement of blood flow in diabetic mice. Pimilprost can be used for the research of metabolic and cardiovascular disease, such as diabetes.
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5,6-trans-Travoprost
0 ImagesCat. No.: HY-B0584ACAS No.: 1563176-59-9Synonyms: 5,6-trans-Fluprostenol isopropyl ester; 5,6-trans-AL6221; 5,6-trans-Flu-Ipr5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension.
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Prostaglandin F2α methyl ester
0 ImagesCat. No.: HY-118648CAS No.: 33854-16-9Synonyms: PGF2α methyl ester; Dinoprost methylProstaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive.
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EP3 antagonist 6
0 ImagesCat. No.: HY-157495CAS No.: 499149-94-9EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC50 of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats.
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15(R)-17-Phenyl trinor Prostaglandin F2α
0 ImagesCat. No.: HY-139121CAS No.: 41639-71-8Synonyms: 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.
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ICI 192605
0 ImagesCat. No.: HY-101236CAS No.: 117621-64-4ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619.
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Tafluprost ethyl ester
0 ImagesCat. No.: HY-116733CAS No.: 209860-89-9Synonyms: AFP-175
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13,14-epoxy Travoprost
0 ImagesCat. No.: HY-114385CAS No.: 2557327-99-6Synonyms: 13,14-epoxy Fluprostenol isopropyl ester13,14-epoxy Travoprost (13,14-epoxy Fluprostenol isopropyl ester) is a mixture of diastereomeric epoxides generated during production of Travoprost (HY-B0584). Travoprost is a selective agonist for prostaglandin F receptor, which exhibits an ocular hypotensive efficacy.
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RS-61756-007
0 ImagesCat. No.: HY-123123CAS No.: 121571-14-0RS-61756-007 is a selective thromboxane receptor (TP) agonist with high activity at the TP receptor. RS-61756-007 showed agonism at TP and FP receptors in in vitro studies but had no activity at other receptor subtypes. The effects of RS-61756-007 can be antagonized in a similar manner by the TP antagonist SQ 29,548.
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Myristinin B/C
0 ImagesCat. No.: HY-N16865Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC50 of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC50 of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis.
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AM432 sodium
0 ImagesCat. No.: HY-122558CAS No.: 1263409-34-2AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease.
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Y-20811 sodium
0 ImagesCat. No.: HY-19039CAS No.: 104363-98-6Y-20811 sodium is a selective and orally active thromboxane synthetase inhibitor. Y-20811 sodium can irreversibly inhibit thromboxane (TX) A2 synthesis. Y-20811 sodium can be used for the research of cardiovascular disease, such as thrombosis.
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17-Phenyl trinor prostaglandin F2α methyl amide
0 ImagesCat. No.: HY-120197CAS No.: 155206-01-217-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding.
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NP-184
0 ImagesCat. No.: HY-W169940CAS No.: 78706-11-3NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases.
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SQ-30741
0 ImagesCat. No.: HY-19078CAS No.: 107332-47-8SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension.
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AZ-11665362
0 ImagesCat. No.: HY-116811CAS No.: 629645-40-5AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.
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15-Keto-prostaglandin E2-d9
0 Images15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
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rel-Latanoprost acid
0 ImagesCat. No.: HY-113756BCAS No.: 2699713-95-4rel-Latanoprost acid is a relative configuration of Latanoprost acid (HY-113756A). Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
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(S)-Butaprost free acid
0 ImagesCat. No.: HY-120973ACAS No.: 433219-55-7(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor.
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Naxaprostene
0 ImagesCat. No.: HY-165434CAS No.: 87269-59-8Synonyms: EL 784Naxaprostene is a prostacyclin analogue. Naxaprostene was much more selective for IP receptors and tended towards partial agonism. Naxaprostene inhibits ADP-induced platelet aggregation. It has been shown to prevent rabbit carotid artery thrombosis.
