Thrombin
Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.
Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.
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Thrombin 関連製品 (236)
関連製品 (236)
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抗体 (9)
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(2S,4S)-Argatroban
0 Images製品番号: HY-B0375BCAS 番号: 189264-03-7別名: (2S,4S)-MD-805; (2S,4S)-MCI-9038(2S,4S)-Argatroban ((2S,4S)-MD-805) (Compound 1c) is human thrombin inhibitor with a Ki of 280 μM.
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Rosenonolactone
0 ImagesRosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.
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Corthrombin
0 Images製品番号: HY-106941CAS 番号: 166247-65-0別名: CVS 995Corthrombin (CVS 995) is a potent alpha-keto-amide thrombin inhibitor with Ki of 1 pM. Corthrombin can be used for the research of cardiovascular disease.
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Thrombin receptor peptide ligand
0 Images製品番号: HY-P5889CAS 番号: 287964-20-9
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Rabbit Thrombin
0 Images製品番号: HY-114164ECAS 番号: 9002-04-4Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia.
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Canine Factor Xa
0 ImagesCanine Factor Xa is a serine protease that plays a central role in blood coagulation, with prothrombin as its physiological substrate. Canine Factor Xa catalyzes the conversion of prothrombin to thrombin, activates factor VIII, and hydrolyzes peptide, thioester, and amide substrates. Canine Factor Xa cleaves protease-activated receptors 1 and 2 to activate intracellular signal transduction. Canine Factor Xa regulates multiple cellular pathways, mediates various cellular activities, tissue remodeling and cancer cell migration, and inhibits apoptosis in some cancer cells. Canine Factor Xa protects hippocampal neurons against glutamate-induced damage. Canine Factor Xa participates in embryonic vascular development and regulates immune hematopoiesis; its activity is inhibited by soybean trypsin inhibitor, and cannot be enhanced by phospholipids. Canine Factor Xa regulates immune responses and macrophage polarization, and participates in fibrosis, vascular remodeling and tumor progression through non-coagulant effects. Canine Factor Xa can be used in research related to atherosclerosis, fibrosis, asthma, cancer, thromboinflammation, sepsis, etc.
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FAM labled Fitusiran sodium
0 Images製品番号: HY-132587DFAM labled Fitusiran sodiumis a FAM labled Fitusiran sodium (HY-132587A). Fitusiran (ALN-AT3SC) sodium is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran sodium enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran sodium can be used in hemophilia-related research.
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Flovagatran
0 Images製品番号: HY-10270CAS 番号: 871576-03-3別名: TGN 255Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
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Hirullin P18
0 Images製品番号: HY-P4259CAS 番号: 131147-81-4Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect.
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Atecegatran metoxil
0 Images製品番号: HY-10273CAS 番号: 433937-93-0別名: AZD0837; Atecegatran fexenetil
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DPC423
0 Images製品番号: HY-11090ACAS 番号: 292135-59-2DPC423 is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis.
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PM102
0 Images製品番号: HY-P1100CAS 番号: 1234564-95-4別名: HepArrestPM102 (HepArrest) is a heparin antagonist that can reverses the anticoagulant effect of heparin. PM102 potently binds heparin (Kd = 36 nM) in vitro.
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Z-Gly-Gly-Arg-AMC hydrochloride
0 Images製品番号: HY-P0019CCAS 番号: 102601-58-1Z-Gly-Gly-Arg-AMC hydrochloride is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm).
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Dabigatran etexilate-d11
0 Images製品番号: HY-W705434CAS 番号: 2469006-94-6別名: BIBR 1048-d11Dabigatran etexilate-d11 (BIBR 1048-d11) is the deuterium labeled Dabigatran etexilate (HY-10274). Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
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Cy3 labled Fitusiran sodium
0 Images製品番号: HY-132587ECy3 labled Fitusiran sodium is a Cy3 labled Fitusiran sodium (HY-132587A). Fitusiran (ALN-AT3SC) sodium is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran sodium enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran sodium can be used in hemophilia-related research.
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Sofigatran
0 Images製品番号: HY-14936CAS 番号: 187602-11-5別名: MCC-977Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.
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AZD-8165
0 Images製品番号: HY-120452CAS 番号: 1201686-72-7AZD-8165 is a highly selective neutral thrombin inhibitor. AZD-8165 is promising for research of cardiovascular diseases such as hypertension and heart failure.
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Rat Factor Xa
0 ImagesRat Factor Xa is a serine protease that plays a central role in blood coagulation, with prothrombin as its physiological substrate. Rat Factor Xa catalyzes the conversion of prothrombin to thrombin, activates factor VIII, and hydrolyzes peptide, thioester, and amide substrates. Rat Factor Xa cleaves protease-activated receptors 1 and 2 to activate intracellular signal transduction. Rat Factor Xa regulates multiple cellular pathways, mediates various cellular activities, tissue remodeling and cancer cell migration, and inhibits apoptosis in some cancer cells. Rat Factor Xa protects hippocampal neurons against glutamate-induced damage. Rat Factor Xa participates in embryonic vascular development and regulates immune hematopoiesis; its activity is inhibited by soybean trypsin inhibitor, and cannot be enhanced by phospholipids. Rat Factor Xa regulates immune responses and macrophage polarization, and participates in fibrosis, vascular remodeling and tumor progression through non-coagulant effects. Rat Factor Xa can be used in research related to atherosclerosis, fibrosis, asthma, cancer, thromboinflammation, sepsis, etc.
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15,16-Dihydrotanshindiol C
0 Images製品番号: HY-N10762CAS 番号: 891854-96-915,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor.
