Aminotransferases (Transaminases)
Aminotransferases (Transaminases)
Aminotransferases (transaminases) are enzymes that catalyze a transamination reaction between amino acids and α-keto acids. They mainly include glutamate-pyruvate transaminase (GPT), also known as alanine aminotransferase (ALT), and glutamate-oxaloacetate transaminase (GOT), also known as aspartate aminotransferase (AST). Aminotransferases (transaminases) play a crucial role in the biosynthesis of non-essential amino acids, helping cells generate the required amino acids by transferring amino groups. Aminotransferases (transaminases) are also involved in the nitrogen-containing compounds metabolism, converting amino acids into forms that are easily excreted or can be used in other metabolic pathways. ALT and AST are often used as clinical diagnostic indicators. An increase in their levels in the blood is often associated with liver diseases such as hepatitis and cirrhosis, heart diseases such as myocardial infarction, and muscle diseases such as polymyositis[1][2].
Aminotransferases (Transaminases) Isoform Specific Products
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Aminotransferases (Transaminases) Related Products (55)
Related Products (55)
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Aminotransferases (Transaminases) Isoform Comparison
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VEGFR-2-IN-88
0 ImagesCat. No.: HY-184719VEGFR-2-IN-88 is a VEGFR-2 inhibitor with an IC50 of 0.202 μM. VEGFR-2-IN-88 potently inhibits EGFR (IC50 = 0.139 μM), and moderately inhibits PDGFR-β (IC50 of 0.236 μM) and c-Met (IC50 of 0.281 μM). VEGFR-2-IN-88 acts as a cell cycle inhibitor that arrests cells at the G0/G1 phase. VEGFR-2-IN-88 induces Apoptosis. VEGFR-2-IN-88 downregulates serum AST and ALT levels. VEGFR-2-IN-88 exerts selective anticancer effects. VEGFR-2-IN-88 reduces liver weight in in vivo models. VEGFR-2-IN-88 can be used in research related to hepatocellular carcinoma.
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Erythromycin estolate (Standard)
0 ImagesErythromycin estolate (Standard) is the analytical standard of Erythromycin estolate. This product is intended for research and analytical applications. Erythromycin estolate is the Erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport.
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Diethyl phthalate-d10
0 ImagesCat. No.: HY-Y0284S1CAS No.: 1817006-92-0Diethyl phthalate-d10 is the d10 labeled Diethyl phthalate (HY-Y0284). Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.
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CSF1R-IN-27
0 ImagesCat. No.: HY-183569CAS No.: 3034296-91-5CSF1R-IN-27 is a CSF1R inhibitor with oral effectiveness, kinome-wide selective profile, low cellular cytotoxicity, and CSF1R IC50 values of 19 nM, 88 nM, 173 nM, 797 nM, 1448 nM, and >3000 nM. CSF1R-IN-27 suppresses M-CSF-induced phosphorylation of CSF1R, AKT, and ERK in macrophages, and inhibits hepatic p-CSF1R/p-AKT/p-ERK signaling. CSF1R-IN-27 reduces serum transaminase levels, improves hepatic histopathology, alleviates inflammatory cell infiltration, and decreases circulating TNF-α and IL-6 levels. CSF1R-IN-27 can be used for the research of acute liver injury.
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D-Amino Acid Transaminase, Bacillus subtilis
0 ImagesCat. No.: HY-E71045D-Amino Acid Transaminase, Bacillus subtilis (EC 2.6.1.21) A pyridoxal phosphatase that acts on a variety of D-amino acids, with D-alanine and D-2-aminobutyric acid being the best amino acid donors.
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PF-04859989
0 ImagesCat. No.: HY-113967CAS No.: 34783-48-7PF-04859989 is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively).
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NSD 1034
0 ImagesNSD 1034 is a potent inhibitor of aromatic L-amino acid decarboxylase (AADC) and tyrosine aminotransferase (TAT), with IC50 values of 0.32 μM and 80 μM, respectively. NSD 1034 increases dopamine synthesis and release by inhibiting AADC and TAT, and stimulating tyrosine hydroxylase in dopaminergic neurons via calcium influx in a classical dopamine receptor-independent manner. NSD 1034 is used in studies of Parkinson's disease and sleep disorders.
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NA808
0 ImagesCat. No.: HY-16342CAS No.: 827034-92-4NA808 is an Serine Palmitoyltransferase (SPT) inhibitor. NA808 reduces sphingomyelin synthesis, inhibits its activation in hepatic stellate cells, and decreases the expression of α-SMA protein and mRNA, as well as collagen 1A1 mRNA (IC50 0.16, 0.12, and 0.11 μM, respectively). NA808 inhibits HCV replication and reduces NS3 and RdRp protein expression in HCV replicon cells without significant cytotoxicity and exhibits almost no immunosuppressive effect at effective concentrations. NA808 demonstrates broad-spectrum antiviral activity in humanized chimeric liver mice infected with various HCV genotypes, and dose-dependently reduces serum and hepatic HCV RNA levels. NA808 can be used for research on non-alcoholic steatohepatitis and hepatitis C virus infection.
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DL-Cycloserine
0 ImagesCat. No.: HY-W008440CAS No.: 68-39-3DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states.
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Erythromycin propionate
0 ImagesErythromycin propionate, erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport.
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Gostatin
0 ImagesCat. No.: HY-N15587CAS No.: 78416-84-9Synonyms: GostatineGostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism.
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Rifamycin AF-013
0 ImagesCat. No.: HY-131319CAS No.: 35225-13-9Rifamycin AF-013 is a derivative of Rifamycin (HY-B1907). Rifamycin AF-013 inhibits DNA polymerase γ by competing with dTTP and template primers for binding. Rifamycin AF-013 exhibits inhibitory activity against Rifampicin (HY-B0272)-resistant RNA polymerase. Rifamycin AF-013 inhibits non-polymerase enzymes including glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and Alkaline phosphatase. Rifamycin AF-013 can be used in research related to Rifampicin-resistant bacterial infections and Ehrlich ascites tumors.
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CPP-115 hydrochloride
0 ImagesCat. No.: HY-W1025152CAS No.: 760947-97-5CPP-115 hydrochloride is an orally active, selective GABA-AT inhibitor with a Ki value of 9.7 μM. CPP-115 hydrochloride blocks GABA degradation and increases GABA levels in the brain. CPP-115 hydrochloride does not bind to GABA transporters, does not displace GABA from GABAA/GABAB receptors, and does not act as an agonist/antagonist of GABAC receptors. CPP-115 hydrochloride reduces cocaine-induced dopamine release, blocks cocaine-induced conditioned place preference, and suppresses seizure activity in a rat model of infantile spasms. CPP-115 hydrochloride can be used in research related to infantile spasms and epilepsy.
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Rhamnetin 3-O-rutinoside
0 ImagesCat. No.: HY-N20705CAS No.: 34202-83-0Rhamnetin 3-O-rutinoside is an antihyperglycemic agent. Rhamnetin 3-O-rutinoside reduces blood glucose levels. Rhamnetin 3-O-rutinoside decreases serum levels of total cholesterol, triglycerides, urea, creatinine, aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT). Rhamnetin 3-O-rutinoside can be used in studies related to diabetes.
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S-Adenosyl-3-thiopropylamine
0 ImagesS-Adenosyl-3-thiopropylamine acts as a weak to moderate reversible inhibitor of spermidine/spermine synthase, and its inhibitory activity increases after oxidation (to S-Adenosyl-3-thiopropylamine sulphoxide and S-Adenosyl-3-thiopropylamine sulphone).
