Calmodulin
Calmodulin; CaM; Calcium-Modulated Protein
Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].
References:
- [1]. Means AR, et al., Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73-7. doi: 10.1038/285073a0 [Content Brief]
- [2]. Kawasaki H, et al., Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition. Sci Rep. 2019 Jul 23;9(1):10688. [Content Brief]
- [3]. Crotti L, et al., Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14;44(35):3357-3370. [Content Brief]
Calmodulin Isoform Specific Products
All Product Categories
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Calmodulin Related Products (60)
Related Products (60)
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Antibodies (4)
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Calmodulin Isoform Comparison
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Encecalinol
0 ImagesCat. No.: HY-N12405CAS No.: 88728-56-7Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.
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Cloxacepride
0 ImagesCat. No.: HY-106645CAS No.: 65569-29-1Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
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Calmodulin-Dependent Protein Kinase II (281-309)
0 ImagesCat. No.: HY-P1874CAS No.: 116826-37-0Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II).
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CV-159
0 ImagesCat. No.: HY-19025CAS No.: 86384-98-7CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
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MLCK Peptide
0 ImagesCat. No.: HY-P10165CAS No.: 209251-64-9MLCK Peptide is a fully reversible, high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase.
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CALM3 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS01842CALM3 Human Pre-designed siRNA Set A contains three designed siRNAs for CALM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
CALM3 siRNA-1: 5 nmol (HPLC)
CALM3 siRNA-2: 5 nmol (HPLC)
CALM3 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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Fasciculic acid B
0 ImagesCat. No.: HY-125412CAS No.: 126882-55-1Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
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Fasciculic acid A
0 ImagesCat. No.: HY-N7733CAS No.: 126906-00-1Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
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Aprindine hydrochloride (Standard)
0 ImagesCat. No.: HY-A0236ARCAS No.: 33237-74-0Aprindine hydrochloride (Standard) is the analytical reference standard of Aprindine hydrochloride (HY-A0236A). This product is used for research and analytical applications. Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.
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Calm2 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS26152Calm2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Calm2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Calm2 siRNA-1: 5 nmol (HPLC)
Calm2 siRNA-2: 5 nmol (HPLC)
Calm2 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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W-7 hydrochloride (Standard)
0 ImagesCat. No.: HY-100912RCAS No.: 61714-27-0W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.
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Elziverine
0 ImagesCat. No.: HY-106745CAS No.: 95520-81-3Synonyms: Ro 22-4839Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation.
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Psoralenoside (Standard)
0 ImagesCat. No.: HY-N7503RCAS No.: 905954-17-8Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
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DC-120
0 ImagesCat. No.: HY-119884CAS No.: 1261080-40-3DC-120 is an ATP-competitive AKT inhibitor, with particular activity against AKT1 (an IC50 of 0.153 μM). DC-120 functionally blocks AKT kinase activity and reduces the phosphorylation levels of FOXO3a and GSK-3β. DC-120 induces cancer cell apoptosis (apoptosis) and inhibits cancer cell proliferation. DC-120 activates the mTORC1 pathway via the Ca2+/calmodulin (calmodulin)/hVps34 signaling pathway. DC-120 abrogates AKT-mediated inhibition of CRAF, thereby activating the MEK/ERK MAPK pathway. DC-120 exerts anti-tumor activity in a nude mouse hepatocellular carcinoma xenograft model. DC-120 can be used for hepatocellular carcinoma-related research.
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Bromoriluzole
0 ImagesCat. No.: HY-W166106CAS No.: 144631-82-3Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca2+ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases.
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Calmidazolium chloride (Standard)
0 ImagesCat. No.: HY-103319RCAS No.: 57265-65-3Synonyms: R 24571 (Standard)Calmidazolium chloride (Standard) is the analytical standard of Calmidazolium chloride (HY-103319). This product is intended for research and analytical applications. Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a Kd of 3 nM.
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Bisindolylmaleimide VII
0 ImagesCat. No.: HY-137045CAS No.: 137592-47-3Bisindolylmaleimide VII is a potent inhibitor of calmodulin with high affinity for calmodulin (Kd=186.2 nM). Bisindolylmaleimide VII is used to study the role of calmodulin in cancer, neurodegenerative diseases, and muscle dysfunction.
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Metofenazate diethanesulfonate
0 ImagesCat. No.: HY-100263BCAS No.: 1674-48-2Synonyms: Methophenazine diethanesulfonateMetofenazate diethanesulfonate is a selective calmodulin inhibitor.
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Arundic Acid (Standard)
0 ImagesCat. No.: HY-107661RCAS No.: 185517-21-9Synonyms: ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
