Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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SKF-83566-PEG1-pomalidomide
0 ImagesCat. No.: HY-180814SKF-83566-PEG1-pomalidomide is an anti-tumor agent and is formed by the covalent connection of SKF-83566 (HY-103430A) (dopamine D1 receptor antagonist) and Pomalidomide (HY-10984) (immunomodulatory agent). SKF-83566-PEG1-pomalidomide can inhibit cancer cells invasion, migration and colony formation. SKF-83566-PEG1-pomalidomide can inhibit tumor growth and angiogenesis in MDA-MB-231 cell chicken embryo chorioallantoic membrane (CAM) xenograft model. SKF-83566-PEG1-pomalidomide can be used for research of breast cancer.
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8-Methoxybonducellin
0 ImagesCat. No.: HY-N11938CAS No.: 90996-27-38-Methoxybonducellin is a natural flavonoid.
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Betulinic acid-OBn
0 ImagesCat. No.: HY-186162CAS No.: 192211-42-0
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Polygonatine A
0 ImagesCat. No.: HY-N10468CAS No.: 400715-63-1Polygonatine A is an alkaloid found in the rhizome of Polygonatum sibiricum Redoute (Liliaceae).
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N-Methyl-1H-indole-2-carboxamide
0 ImagesN-Methyl-1H-indole-2-carboxamide is an indole derivative found in the marine fungus Cladosporium cladosporioides.
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Citrusin
0 ImagesCat. No.: HY-N16756CAS No.: 108943-57-3Citrusin is a natural triterpene.
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Inonotsutriol C
0 ImagesCat. No.: HY-N17564CAS No.: 1078127-81-7Inonotsutriol C is a lanostane-type triterpenoid found in the sclerotia of Inonotus obliquus.
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MG16
0 ImagesCat. No.: HY-182071CAS No.: 2349329-01-5MG16 is a prodrug of 10-Methoxycamptothecin (HY-N0446). MG16 downregulates CDK6 and upregulates ASK1. MG16 induces cell cycle arrest and Apoptosis. MG16 exhibits anticancer activity against Lewis lung carcinoma, small cell lung cancer, and non-small cell lung cancer.
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Morusalfuran C
0 ImagesCat. No.: HY-N17422CAS No.: 1941207-34-6Morusalfuran C is a natural product that can be found in mulberry.
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Anibadimer A
0 ImagesCat. No.: HY-N17109CAS No.: 23768-65-2Anibadimer A is a natural phenolic compound.
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4-Pentynoyl-Coenzyme A TFA
0 ImagesCat. No.: HY-CE00983ASynonyms: 4-Pentynoyl-CoA TFA4-Pentynoyl-Coenzyme A (4-Pentynoyl-CoA) TFA is an analog of the natural substrate acetyl-CoA (Acetyl-CoA) (HY-114293). 4-Pentynoyl-Coenzyme A TFA can replace acetyl-CoA to be recognized and utilized by lysine acetyltransferases such as p300. 4-Pentynoyl-Coenzyme A TFA can be conjugated to azide probes carrying fluorescent groups (e.g., Rhodamine-azide) or biotin (Biotin-azide) via Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC).
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Tetramethylpyrazine nitrone
0 ImagesCat. No.: HY-202233CAS No.: 1083171-75-8Synonyms: TBNTetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin.
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Cinfenoac disodium
0 ImagesCat. No.: HY-W300403ACAS No.: 68461-38-1Cinfenoac disodium is a chalcone derivative with anti-inflammatory activity and can be used in the study of allergic diseases.
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Leu-thiorphan
0 ImagesCat. No.: HY-126991CAS No.: 80970-04-3Leu-thiorphan is an active compound.
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Negundonorin A
0 ImagesCat. No.: HY-N16860CAS No.: 1401618-51-6Negundonorin A is a natural triterpene.
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N-Cbz-DL-tryptophan
0 ImagesSynonyms: Z-DL-Trp-OHN-Cbz-DL-tryptophan (Z-DL-Trp-OH) is the enantiomer of Tryptophan (HY-N0623) derivative. N-Cbz-DL-tryptophan is a cholecystokinin receptor antagonist.
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Aristolodione
0 ImagesCat. No.: HY-N17018CAS No.: 109771-09-7Synonyms: PiperadioneAristolodione (Piperadione) is a natural alkaloid.
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12α-Methoxyabietic acid
0 ImagesCat. No.: HY-N17133CAS No.: 83905-80-012α-Methoxyabietic acid is a natural diterpene.
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Antitumor agent-209
0 ImagesCat. No.: HY-177967CAS No.: 1616473-67-6Antitumor agent-209 (Compound 10g), a quinolone derivative, is an antitumor agent. Antitumor agent-209 can inhibit proliferation of HCT-116, RKO, DLD1, HepG2, BGC-823, NCI-H1650 and SK-OV-3 cells with IC50 values of 0.37, 0.58, 0.81, 0.79, 0.89, 0.78 and 0.89 μM.
